PDBj (Protein Data Bank Japan) maintains a centralized PDB archive of macromolecular structures and provides integrated tools, in collaboration with the RCSB, the BMRB in USA and the PDBe in EU. PDBj is supported by JST-NBDC and Osaka University.
THROMBIN (E.C.3.4.21.5), LIGHT AND HEAVY CHAINS/INHIBITOR HIRUDIN
Title
A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE
Functional Keywords
three-centered, very short hydrogen bond, oxyanion hole water, shift of pKa of His57, structure-based drug design, specificity, urokinase, trypsin, thrombin, Zn+2-mediated inhibition, BLOOD CLOTTING
Katz, B.A. , Elrod, K. , Luong, C. , Rice, M. , Mackman, R.L. , Sprengeler, P.A. , Spencer, J. , Hatayte, J. , Janc, J. , Link, J. , Litvak, J. , Rai, R. , Rice, K. , Sideris, S. , Verner, E. , Young, W.
(deposition date : 2001-01-22, release date : 2002-01-22)
Primary citation
Katz, B.A. , Elrod, K. , Luong, C. , Rice, M.J. , Mackman, R.L. , Sprengeler, P.A. , Spencer, J. , Hataye, J. , Janc, J. , Link, J. , Litvak, J. , Rai, R. , Rice, K. , Sideris, S. , Verner, E. , Young, W. A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site. J. Mol. Biol.,
307:1451 - 1486, 2001.(PubMed : 11292354)(DOI: 10.1006/jmbi.2001.4516)
