Gene information | Cerebellar Development Transcriptome Database (CDT-DB)

CD gene Number	CD18259
Gene Symbol	Fgfr2
Gene description	fibroblast growth factor receptor 2
Alternative name(s)	OTTMUSP00000040879; OTTMUSP00000040880; OTTMUSP00000040881; OTTMUSP00000040981; OTTMUSP00000040982; OTTMUSP00000040983; OTTMUSP00000040984; OTTMUSP00000040985; OTTMUSP00000040986; OTTMUSP00000040987; OTTMUSP00000040988; OTTMUSP00000040989; OTTMUSP00000040990; OTTMUSP00000040991; OTTMUSP00000040992; OTTMUSP00000040993; keratinocyte growth factor receptor
Alternative name(s)	Bek, svs, Fgfr7, Fgfr-2, Fgfr-7, KGFRTr, AU043015, AW556123, MGC102519
Accession ID	NM_010207 , NM_201601
Gene Category
Gene Ontology	biological_process angiogenesis , axonogenesis , bone development , bone mineralization , bone morphogenesis , branch elongation involved in salivary gland morphogenesis , branching involved in embryonic placenta morphogenesis , branching involved in prostate gland morphogenesis , branching involved in salivary gland morphogenesis , branching morphogenesis of a nerve , bud elongation involved in lung branching , cell fate commitment , cell-cell signaling , cellular response to protein stimulus , digestive tract development , embryonic digestive tract morphogenesis , embryonic organ development , embryonic organ morphogenesis , embryonic pattern specification , epidermis morphogenesis , epithelial cell differentiation , epithelial cell proliferation , epithelial cell proliferation involved in salivary gland morphogenesis , epithelial to mesenchymal transition , fibroblast growth factor receptor signaling pathway , fibroblast growth factor receptor signaling pathway involved in mammary gland specification , gland morphogenesis , hair follicle morphogenesis , in utero embryonic development , inner ear morphogenesis , lacrimal gland development , lateral sprouting from an epithelium , limb bud formation , lung alveolus development , lung development , lung lobe morphogenesis , lung-associated mesenchyme development , mammary gland bud formation , membranous septum morphogenesis , mesenchymal cell differentiation , mesenchymal cell differentiation involved in lung development , mesenchymal cell proliferation involved in lung development , midbrain development , morphogenesis of embryonic epithelium , multicellular organism growth , negative regulation of epithelial cell proliferation , negative regulation of gene-specific transcription from RNA polymerase II promoter , odontogenesis , organ growth , organ morphogenesis , otic vesicle formation , outflow tract septum morphogenesis , positive regulation of cardiac muscle cell proliferation , positive regulation of cell division , positive regulation of cell proliferation , positive regulation of epithelial cell proliferation , positive regulation of epithelial cell proliferation involved in lung morphogenesis , positive regulation of ERK1 and ERK2 cascade , positive regulation of gene-specific transcription from RNA polymerase II promoter , positive regulation of mesenchymal cell proliferation , positive regulation of smooth muscle cell proliferation , positive regulation of Wnt receptor signaling pathway , positive regulation of Wnt receptor signaling pathway through beta-catenin , post-embryonic development , prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis , prostate epithelial cord elongation , prostate gland morphogenesis , protein amino acid phosphorylation , regulation of branching involved in prostate gland morphogenesis , regulation of cell fate commitment , regulation of cell proliferation , regulation of epithelial cell proliferation , regulation of ERK1 and ERK2 cascade ... [Show All] molecular_function ATP binding , fibroblast growth factor 1 binding , fibroblast growth factor binding , fibroblast growth factor receptor activity , heparin binding , kinase activity , nucleotide binding , protein binding , protein kinase activity , protein tyrosine kinase activity , receptor activity , transferase activity , transmembrane receptor protein tyrosine kinase activity ... [Show All]
Temporal expression	pending
Spatial expression (characteristic site)	P7 : P21 :
Brain distribution (characteristic site)	P7 : P21 :
Brain specificity
Experimental data	Temporal Tissue
Probe	CDT EST : Affymetrix : 1420847_a_at (MG 430 2.0 Array)
Links	General information Entrez Gene : 14183 MGI : 95523 Ensembl : ENSMUSG00000030849 UniGene : Mm.16340 OMIM : 176943 GEO : Fgfr2 KEGG : Endocytosis 04144, MAPK signaling pathway 04010, Pathways in cancer 05200, Prostate cancer 05215, Regulation of actin cytoskeleton 04810 Genome information Harvester UCSC Mouse Genome Browser Gateway Perlegen/NIEHS Mouse Genome Browser Functional genomics GeneNetwork Mouse Phenome Database BioGPS STRING Nervous system SynDB Mouse Neuronal Expression Database Reference information GoPubMed iHOP PubMed Spatial information ABA GenePaint BGEM
References	20410112 Fgfr2 is required for the development of the medial prefrontal cortex and its connections with limbic circuits 20308431 Fibroblast growth factor receptors 1 and 2 in keratinocytes control the epidermal barrier and cutaneous homeostasis 20303521 High incidence of vesicoureteral reflux in mice with Fgfr2 deletion in kidney mesenchyma 20175913 Activation of p38 MAPK pathway in the skull abnormalities of Apert syndrome Fgfr2(+P253R) mice 20133659 Analysis of a gain-of-function FGFR2 Crouzon mutation provides evidence of loss of function activity in the etiology of cleft palate Show all (11) references (detailed information)

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