Gene information
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CD gene Number CD41995 
Gene Symbol Runx1     
Gene description runt related transcription factor 1 
Alternative name(s) SL3-3 enhancer factor 1 alpha; runt-related transcription factor 1; CBF-alpha-2; PEA2-alpha B; PEBP2-alpha B; oncogene AML-1; core binding factor alpha 2; runt domain, alpha subunit 2; acute myeloid leukemia 1 protein; core-binding factor subunit alpha-2; SL3-3 enhancer factor 1 alpha B subunit; SL3/AKV core-binding factor alpha B subunit; polyomavirus enhancer-binding protein 2 alpha B subunit 
AML1, Cbfa2, Pebp2a2, Pebpa2b, AI462102 
Accession ID NM_001111021 ,  NM_001111022 ,  NM_001111023 ,  NM_009821  
Gene Category  
Gene Ontology biological_process
behavioral response to pain , central nervous system development , definitive hemopoiesis , embryonic hemopoiesis , hemopoiesis , in utero embryonic development , liver development , neuron development , neuron differentiation , positive regulation of angiogenesis , regulation of transcription , regulation of transcription, DNA-dependent , response to retinoic acid , skeletal system development , transcription ... [Show All]

cellular_component
nucleus

molecular_function
ATP binding , DNA binding , protein binding , transcription factor activity

Temporal expression pending  
Spatial expression (characteristic site) P7 :
P21 :
Brain distribution (characteristic site) P7 :
P21 :
Brain specificity  
Experimental data Temporal Temporal information Tissue Tissue information  
Probe CDT EST :  
Affymetrix : 1452578_at (MG 430 2.0 Array)
Links General information
Entrez Gene : 12394
MGI : 99852
Ensembl : ENSMUSG00000022952
UniGene : Mm.4081, Mm.470227
OMIM : 151385
GEO : Runx1
KEGG : Acute myeloid leukemia 05221, Chronic myeloid leukemia 05220, Pathways in cancer 05200
Genome information
Harvester
UCSC Mouse Genome Browser Gateway
Perlegen/NIEHS Mouse Genome Browser
Functional genomics
GeneNetwork
Mouse Phenome Database
BioGPS
STRING
Nervous system
SynDB
Mouse Neuronal Expression Database
Reference information
GoPubMed
iHOP
PubMed
Spatial information
ABA
GenePaint
BGEM
References

  • 20385820 Compound haploinsufficiencies of Ebf1 and Runx1 genes impede B cell lineage progression
  • 20206228 Runx1 isoforms show differential expression patterns during hematopoietic development but have similar functional effects in adult hematopoietic stem cells
  • 20187849 In vitro and in vivo effects on neural crest stem cell differentiation by conditional activation of Runx1 short isoform and its effect on neuropathic pain behavior
  • 20181744 Runx1 and Runx2 cooperate during sternal morphogenesis
  • 20152828 The essential requirement for Runx1 in the development of the sternum
Show all (12) references (detailed information)


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