CD00070

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD00070

CD00070

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Mll5

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• myeloid/lymphoid or mixed-lineage leukemia 5

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• myeloid/lymphoid or mixed-lineage leukemia protein 5 homolog
• myeloid/lymphoid or mixed-lineage leukemia 5
• histone-lysine N-methyltransferase MLL5

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• Kmt2E
• 1810033J14Rik
• 9530077A04Rik
• D230038D11Rik

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/69188

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• lysine (K)-specific methyltransferase 2E
  http://metadb.riken.jp/db/mgi_rdf/MGI:1924825

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_026984

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000029004

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.205190
• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.403814

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• Michael. Heuser, et.al., Loss of MLL5 results in pleiotropic hematopoietic defects, reduced neutrophil immune function, and extreme sensitivity to DNA demethylation., Blood, 2009, 113
  http://rdf.ncbi.nlm.nih.gov/pubmed/18854576
• Yan. Zhang, et.al., MLL5 contributes to hematopoietic stem cell fitness and homeostasis., Blood, 2009, 113
  http://rdf.ncbi.nlm.nih.gov/pubmed/18818388
• Doug. Stryke, et.al., BayGenomics: a resource of insertional mutations in mouse embryonic stem cells., Nucleic acids research, 2003, 31
  http://rdf.ncbi.nlm.nih.gov/pubmed/12520002
• Vikas. Madan, et.al., Impaired function of primitive hematopoietic cells in mice lacking the Mixed-Lineage-Leukemia homolog MLL5., Blood, 2009, 113
  http://rdf.ncbi.nlm.nih.gov/pubmed/18952892
• Shigetoshi. Yokoyama, et.al., A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58., Developmental cell, 2009, 17
  http://rdf.ncbi.nlm.nih.gov/pubmed/20059953
• C David. Allis, et.al., New nomenclature for chromatin-modifying enzymes., Cell, 2007, 131
  http://rdf.ncbi.nlm.nih.gov/pubmed/18022353
• Soji. Sebastian, et.al., MLL5, a trithorax homolog, indirectly regulates H3K4 methylation, represses cyclin A2 expression, and promotes myogenic differentiation., Proceedings of the National Academy of Sciences of the United States of America, 2009, 106
  http://rdf.ncbi.nlm.nih.gov/pubmed/19264965
• Roland H. Friedel, et.al., EUCOMM--the European conditional mouse mutagenesis program., Briefings in functional genomics & proteomics, 2007, 6
  http://rdf.ncbi.nlm.nih.gov/pubmed/17967808
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• covalent chromatin modification
  http://purl.obolibrary.org/obo/GO_0016569
• DNA methylation
  http://purl.obolibrary.org/obo/GO_0006306
• cell cycle arrest
  http://purl.obolibrary.org/obo/GO_0007050
• cellular response to retinoic acid
  http://purl.obolibrary.org/obo/GO_0071300
• erythrocyte differentiation
  http://purl.obolibrary.org/obo/GO_0030218
• retinoic acid receptor signaling pathway
  http://purl.obolibrary.org/obo/GO_0048384
• histone H3-K4 methylation
  http://purl.obolibrary.org/obo/GO_0051568
• neutrophil activation
  http://purl.obolibrary.org/obo/GO_0042119
• histone lysine methylation
  http://purl.obolibrary.org/obo/GO_0034968
• histone-lysine N-methyltransferase activity
  http://purl.obolibrary.org/obo/GO_0018024
• nucleus
  http://purl.obolibrary.org/obo/GO_0005634
• neutrophil mediated immunity
  http://purl.obolibrary.org/obo/GO_0002446
• zinc ion binding
  http://purl.obolibrary.org/obo/GO_0008270
• regulation of transcription, DNA-templated
  http://purl.obolibrary.org/obo/GO_0006355
• transcription coactivator activity
  http://purl.obolibrary.org/obo/GO_0003713
• methyltransferase activity
  http://purl.obolibrary.org/obo/GO_0008168
• positive regulation of transcription, DNA-templated
  http://purl.obolibrary.org/obo/GO_0045893
• transferase activity
  http://purl.obolibrary.org/obo/GO_0016740
• positive regulation of granulocyte differentiation
  http://purl.obolibrary.org/obo/GO_0030854
• chromatin organization
  http://purl.obolibrary.org/obo/GO_0006325
• metal ion binding
  http://purl.obolibrary.org/obo/GO_0046872
• transcription, DNA-templated
  http://purl.obolibrary.org/obo/GO_0006351
• cell cycle
  http://purl.obolibrary.org/obo/GO_0007049
• peptidyl-lysine methylation
  http://purl.obolibrary.org/obo/GO_0018022
• methylation
  http://purl.obolibrary.org/obo/GO_0032259
• enzyme binding
  http://purl.obolibrary.org/obo/GO_0019899
• histone methyltransferase activity (H3-K4 specific)
  http://purl.obolibrary.org/obo/GO_0042800

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map00310

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Lysine degradation