CD00416

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD00416

CD00416

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Tcof1

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• Treacher Collins Franceschetti syndrome 1, homolog

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• treacle protein
• Treacher Collins Franceschetti syndrome 1, homolog
• treacher Collins syndrome protein homolog

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• treacle
• AW209012
• AA408847

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/21453

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• treacle ribosome biogenesis factor 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:892003

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_011552
• https://www.ncbi.nlm.nih.gov/nuccore/NM_001198984

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000024613

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.2215

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=606847

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• Kathryn H. Shows, et.al., Regulation of the mouse Treacher Collins syndrome homolog (Tcof1) promoter through differential repression of constitutive expression., DNA and cell biology, 2008, 27
  http://rdf.ncbi.nlm.nih.gov/pubmed/18771418
• J. Dixon, et.al., Sequence analysis, identification of evolutionary conserved motifs and expression analysis of murine tcof1 provide further evidence for a potential function for the gene and its human homologue, TCOF1., Human molecular genetics, 1997, 6
  http://rdf.ncbi.nlm.nih.gov/pubmed/9158147
• Natalie C. Jones, et.al., Prevention of the neurocristopathy Treacher Collins syndrome through inhibition of p53 function., Nature medicine, 2008, 14
  http://rdf.ncbi.nlm.nih.gov/pubmed/18246078
• Carol A. Richter, et.al., Defects in middle ear cavitation cause conductive hearing loss in the Tcof1 mutant mouse., Human molecular genetics, 2010, 19
  http://rdf.ncbi.nlm.nih.gov/pubmed/20106873
• Daisuke. Sakai, et.al., Treacher Collins syndrome: unmasking the role of Tcof1/treacle., The international journal of biochemistry & cell biology, 2009, 41
  http://rdf.ncbi.nlm.nih.gov/pubmed/19027870
• P. Hedera, et.al., Novel autosomal dominant mandibulofacial dysostosis with ptosis: clinical description and exclusion of TCOF1., Journal of medical genetics, 2002, 39
  http://rdf.ncbi.nlm.nih.gov/pubmed/12114479
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• E W. Jabs, et.al., Genetic and physical mapping of the Treacher Collins syndrome locus with respect to loci in the chromosome 5q3 region., Genomics, 1993, 18
  http://rdf.ncbi.nlm.nih.gov/pubmed/8276417
• C A. Wise, et.al., TCOF1 gene encodes a putative nucleolar phosphoprotein that exhibits mutations in Treacher Collins Syndrome throughout its coding region., Proceedings of the National Academy of Sciences of the United States of America, 1997, 94
  http://rdf.ncbi.nlm.nih.gov/pubmed/9096354
• Y. Pan, et.al., Retrotransposition of glycerol kinase-related genes from the X chromosome to autosomes: functional and evolutionary aspects., Genomics, 1999, 59
  http://rdf.ncbi.nlm.nih.gov/pubmed/10444329
• J. Dixon, et.al., Increased levels of apoptosis in the prefusion neural folds underlie the craniofacial disorder, Treacher Collins syndrome., Human molecular genetics, 2000, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/10888597
• W A. Paznekas, et.al., Mouse TCOF1 is expressed widely, has motifs conserved in nucleolar phosphoproteins, and maps to chromosome 18., Biochemical and biophysical research communications, 1997, 238
  http://rdf.ncbi.nlm.nih.gov/pubmed/9299440

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• cytoplasm
  http://purl.obolibrary.org/obo/GO_0005737
• nucleus
  http://purl.obolibrary.org/obo/GO_0005634
• nucleolus
  http://purl.obolibrary.org/obo/GO_0005730
• transcription of nuclear large rRNA transcript from RNA polymerase I promoter
  http://purl.obolibrary.org/obo/GO_0042790
• transport
  http://purl.obolibrary.org/obo/GO_0006810

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map03008

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Ribosome biogenesis in eukaryotes