CD00467

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD00467

CD00467

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Plcb1

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• phospholipase C, beta 1

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• PLC-154
• 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1
• phospholipase C, beta 1
• phosphoinositide phospholipase C
• phospholipase C-beta-1
• phosphoinositide phospholipase C-beta-1
• phospholipase C-beta-1a
• PLC-beta-1

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• mKIAA0581
• PLCbeta1
• Plcb
• PI-PLC
• PLC-154
• 3110043I21Rik
• PLC'1
• AI132408
• PLC-I
• Phosphb

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/18795

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• phospholipase C, beta 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:97613

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_001145830
• https://www.ncbi.nlm.nih.gov/nuccore/NM_019677

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000051177

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.330607

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=607120

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• Stefanie. Seehaus, et.al., Hypercoagulability inhibits monocyte transendothelial migration through protease-activated receptor-1-, phospholipase-Cbeta-, phosphoinositide 3-kinase-, and nitric oxide-dependent signaling in monocytes and promotes plaque stability., Circulation, 2009, 120
  http://rdf.ncbi.nlm.nih.gov/pubmed/19687358
• M S. Lyu, et.al., Genetic mapping of the human and mouse phospholipase C genes., Mammalian genome : official journal of the International Mammalian Genome Society, 1996, 7
  http://rdf.ncbi.nlm.nih.gov/pubmed/8672127
• A R. Zuberi, et.al., A genetic linkage map of mouse chromosome 2 extending from thrombospondin to paired box gene 1, including the H3 minor histocompatibility complex., Genomics, 1996, 33
  http://rdf.ncbi.nlm.nih.gov/pubmed/8617512
• Simon J. O'Carroll, et.al., Nuclear PLCbeta1 is required for 3T3-L1 adipocyte differentiation and regulates expression of the cyclin D3-cdk4 complex., Cellular signalling, 2009, 21
  http://rdf.ncbi.nlm.nih.gov/pubmed/19385066
• T. Nagase, et.al., Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro., DNA research : an international journal for rapid publication of reports on genes and genomes, 1998, 5
  http://rdf.ncbi.nlm.nih.gov/pubmed/9628581
• I. Ruiz de Azúa, et.al., Reduced phospholipase C-beta activity and isoform expression in the cerebellum of TS65Dn mouse: a model of Down syndrome., Journal of neuroscience research, 2001, 66
  http://rdf.ncbi.nlm.nih.gov/pubmed/11746373
• E J. Hess, et.al., Deletion map of the coloboma (Cm) locus on mouse chromosome 2., Genomics, 1994, 21
  http://rdf.ncbi.nlm.nih.gov/pubmed/7916325
• L D. Walensky, et.al., Inositol 1,4,5-trisphosphate receptors selectively localized to the acrosomes of mammalian sperm., The Journal of cell biology, 1995, 130
  http://rdf.ncbi.nlm.nih.gov/pubmed/7642703
• Elizabeth A. Woodcock, et.al., Selective activation of the "b" splice variant of phospholipase Cbeta1 in chronically dilated human and mouse atria., Journal of molecular and cellular cardiology, 2009, 47
  http://rdf.ncbi.nlm.nih.gov/pubmed/19729020
• Pan-Yue. Deng, et.al., Cholecystokinin facilitates glutamate release by increasing the number of readily releasable vesicles and releasing probability., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, 30
  http://rdf.ncbi.nlm.nih.gov/pubmed/20392936
• E J. Weeber, et.al., Fear conditioning-induced alterations of phospholipase C-beta1a protein level and enzyme activity in rat hippocampal formation and medial frontal cortex., Neurobiology of learning and memory, 2001, 76
  http://rdf.ncbi.nlm.nih.gov/pubmed/11502147
• W M. Hempel, et.al., Expression of phospholipase C isozymes by murine B lymphocytes., Journal of immunology (Baltimore, Md. : 1950), 1991, 146
  http://rdf.ncbi.nlm.nih.gov/pubmed/2033248
• Stan. Grinberg, et.al., Suppression of PLCbeta2 by endotoxin plays a role in the adenosine A(2A) receptor-mediated switch of macrophages from an inflammatory to an angiogenic phenotype., The American journal of pathology, 2009, 175
  http://rdf.ncbi.nlm.nih.gov/pubmed/19850892

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• phospholipase C activity
  http://purl.obolibrary.org/obo/GO_0004629
• macrophage differentiation
  http://purl.obolibrary.org/obo/GO_0030225
• intracellular signal transduction
  http://purl.obolibrary.org/obo/GO_0035556
• nuclear chromatin
  http://purl.obolibrary.org/obo/GO_0000790
• positive regulation of transcription, DNA-templated
  http://purl.obolibrary.org/obo/GO_0045893
• insulin-like growth factor receptor signaling pathway
  http://purl.obolibrary.org/obo/GO_0048009
• positive regulation of interleukin-12 production
  http://purl.obolibrary.org/obo/GO_0032735
• cerebral cortex development
  http://purl.obolibrary.org/obo/GO_0021987
• negative regulation of monocyte extravasation
  http://purl.obolibrary.org/obo/GO_2000438
• intracellular
  http://purl.obolibrary.org/obo/GO_0005622
• oocyte maturation
  http://purl.obolibrary.org/obo/GO_0001556
• insulin receptor signaling pathway
  http://purl.obolibrary.org/obo/GO_0008286
• nucleus
  http://purl.obolibrary.org/obo/GO_0005634
• hydrolase activity
  http://purl.obolibrary.org/obo/GO_0016787
• positive regulation of acrosome reaction
  http://purl.obolibrary.org/obo/GO_2000344
• phosphatidylinositol phospholipase C activity
  http://purl.obolibrary.org/obo/GO_0004435
• enzyme binding
  http://purl.obolibrary.org/obo/GO_0019899
• positive regulation of GTPase activity
  http://purl.obolibrary.org/obo/GO_0043547
• regulation of fertilization
  http://purl.obolibrary.org/obo/GO_0080154
• response to monosaccharide
  http://purl.obolibrary.org/obo/GO_0034284
• glutamate receptor signaling pathway
  http://purl.obolibrary.org/obo/GO_0007215
• nuclear speck
  http://purl.obolibrary.org/obo/GO_0016607
• signal transducer activity
  http://purl.obolibrary.org/obo/GO_0004871
• G2/M transition of mitotic cell cycle
  http://purl.obolibrary.org/obo/GO_0000086
• CD24 biosynthetic process
  http://purl.obolibrary.org/obo/GO_0035724
• fat cell differentiation
  http://purl.obolibrary.org/obo/GO_0045444
• negative regulation of transcription, DNA-templated
  http://purl.obolibrary.org/obo/GO_0045892
• brain development
  http://purl.obolibrary.org/obo/GO_0007420
• regulation of G-protein coupled receptor protein signaling pathway
  http://purl.obolibrary.org/obo/GO_0008277
• positive regulation of sodium:proton antiporter activity
  http://purl.obolibrary.org/obo/GO_0032417
• lipid metabolic process
  http://purl.obolibrary.org/obo/GO_0006629
• phosphatidylinositol-4,5-bisphosphate binding
  http://purl.obolibrary.org/obo/GO_0005546
• mRNA processing
  http://purl.obolibrary.org/obo/GO_0006397
• calmodulin binding
  http://purl.obolibrary.org/obo/GO_0005516
• positive regulation of embryonic development
  http://purl.obolibrary.org/obo/GO_0040019
• G-protein coupled acetylcholine receptor signaling pathway
  http://purl.obolibrary.org/obo/GO_0007213
• lipid catabolic process
  http://purl.obolibrary.org/obo/GO_0016042
• activation of meiosis involved in egg activation
  http://purl.obolibrary.org/obo/GO_0060466
• interleukin-12-mediated signaling pathway
  http://purl.obolibrary.org/obo/GO_0035722
• interleukin-15-mediated signaling pathway
  http://purl.obolibrary.org/obo/GO_0035723
• lamin binding
  http://purl.obolibrary.org/obo/GO_0005521
• membrane fraction
  http://purl.obolibrary.org/obo/GO_0005624
• GTPase activator activity
  http://purl.obolibrary.org/obo/GO_0005096
• G1 phase
  http://purl.obolibrary.org/obo/GO_0051318
• erythrocyte differentiation
  http://purl.obolibrary.org/obo/GO_0030218
• protein binding
  http://purl.obolibrary.org/obo/GO_0005515
• interleukin-1-mediated signaling pathway
  http://purl.obolibrary.org/obo/GO_0070498
• cell adhesion
  http://purl.obolibrary.org/obo/GO_0007155
• positive regulation of developmental growth
  http://purl.obolibrary.org/obo/GO_0048639
• protein homodimerization activity
  http://purl.obolibrary.org/obo/GO_0042803
• positive regulation of myoblast differentiation
  http://purl.obolibrary.org/obo/GO_0045663
• phosphoric diester hydrolase activity
  http://purl.obolibrary.org/obo/GO_0008081
• signal transduction
  http://purl.obolibrary.org/obo/GO_0007165
• response to peptide hormone
  http://purl.obolibrary.org/obo/GO_0043434
• cytoplasm
  http://purl.obolibrary.org/obo/GO_0005737
• positive regulation of JNK cascade
  http://purl.obolibrary.org/obo/GO_0046330
• cytosol
  http://purl.obolibrary.org/obo/GO_0005829
• calcium ion binding
  http://purl.obolibrary.org/obo/GO_0005509
• memory
  http://purl.obolibrary.org/obo/GO_0007613

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map04062
• http://www.genome.jp/dbget-bin/www_bget?map04970
• http://www.genome.jp/dbget-bin/www_bget?map04310
• http://www.genome.jp/dbget-bin/www_bget?map04961
• http://www.genome.jp/dbget-bin/www_bget?map05142
• http://www.genome.jp/dbget-bin/www_bget?map04912
• http://www.genome.jp/dbget-bin/www_bget?map04724
• http://www.genome.jp/dbget-bin/www_bget?map04730
• http://www.genome.jp/dbget-bin/www_bget?map01100
• http://www.genome.jp/dbget-bin/www_bget?map04971
• http://www.genome.jp/dbget-bin/www_bget?map05010
• http://www.genome.jp/dbget-bin/www_bget?map05143
• http://www.genome.jp/dbget-bin/www_bget?map04070
• http://www.genome.jp/dbget-bin/www_bget?map04725
• http://www.genome.jp/dbget-bin/www_bget?map04916
• http://www.genome.jp/dbget-bin/www_bget?map05146
• http://www.genome.jp/dbget-bin/www_bget?map04728
• http://www.genome.jp/dbget-bin/www_bget?map00562
• http://www.genome.jp/dbget-bin/www_bget?map05016
• http://www.genome.jp/dbget-bin/www_bget?map04540
• http://www.genome.jp/dbget-bin/www_bget?map04972
• http://www.genome.jp/dbget-bin/www_bget?map04020
• http://www.genome.jp/dbget-bin/www_bget?map04270
• http://www.genome.jp/dbget-bin/www_bget?map04720

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Alzheimer's disease
• GnRH signaling pathway
• Long-term depression
• Long-term potentiation
• Endocrine and other factor-regulated calcium reabsorption
• Pancreatic secretion
• Inositol phosphate metabolism
• Phosphatidylinositol signaling system
• Gap junction
• Chemokine signaling pathway
• Vascular smooth muscle contraction
• Cholinergic synapse
• Salivary secretion
• Amoebiasis
• Melanogenesis
• Glutamatergic synapse
• Calcium signaling pathway
• African trypanosomiasis
• Huntington's disease
• Metabolic pathways
• Gastric acid secretion
• Dopaminergic synapse
• Wnt signaling pathway
• Chagas disease (American trypanosomiasis)