CD00609

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD00609

CD00609

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Ubr2

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• ubiquitin protein ligase E3 component n-recognin 2

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• N-recognin-2
• ubiquitin-protein ligase E3-alpha-2
• ubiquitin-protein ligase E3-alpha-II
• E3 ubiquitin-protein ligase UBR2
• ubiquitin ligase E3 alpha-II
• ubiquitin protein ligase E3 component n-recognin 2

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• E130209G04Rik
• AI462103
• mKIAA0349
• 9930021A08Rik
• ENSMUSG00000043296
• AW540746

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/224826

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• ubiquitin protein ligase E3 component n-recognin 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:1861099

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_146078
• https://www.ncbi.nlm.nih.gov/nuccore/NM_001177374

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000023977

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.28234

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=609134

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• Yan. Ouyang, et.al., Loss of Ubr2, an E3 ubiquitin ligase, leads to chromosome fragility and impaired homologous recombinational repair., Mutation research, 2006, 596
  http://rdf.ncbi.nlm.nih.gov/pubmed/16488448
• Noriko. Okazaki, et.al., Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries., DNA research : an international journal for rapid publication of reports on genes and genomes, 2003, 10
  http://rdf.ncbi.nlm.nih.gov/pubmed/12693553
• Y T. Kwon, et.al., Altered activity, social behavior, and spatial memory in mice lacking the NTAN1p amidase and the asparagine branch of the N-end rule pathway., Molecular and cellular biology, 2000, 20
  http://rdf.ncbi.nlm.nih.gov/pubmed/10805755
• Jee Young. An, et.al., UBR2 mediates transcriptional silencing during spermatogenesis via histone ubiquitination., Proceedings of the National Academy of Sciences of the United States of America, 2010, 107
  http://rdf.ncbi.nlm.nih.gov/pubmed/20080676
• Y T. Kwon, et.al., Construction and analysis of mouse strains lacking the ubiquitin ligase UBR1 (E3alpha) of the N-end rule pathway., Molecular and cellular biology, 2001, 21
  http://rdf.ncbi.nlm.nih.gov/pubmed/11689692
• Jee Young. An, et.al., Impaired neurogenesis and cardiovascular development in mice lacking the E3 ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway., Proceedings of the National Academy of Sciences of the United States of America, 2006, 103
  http://rdf.ncbi.nlm.nih.gov/pubmed/16606826
• Keith S. Kwak, et.al., Regulation of protein catabolism by muscle-specific and cytokine-inducible ubiquitin ligase E3alpha-II during cancer cachexia., Cancer research, 2004, 64
  http://rdf.ncbi.nlm.nih.gov/pubmed/15548684
• Martin. Zenker, et.al., Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome)., Nature genetics, 2005, 37
  http://rdf.ncbi.nlm.nih.gov/pubmed/16311597
• Yong Tae. Kwon, et.al., Female lethality and apoptosis of spermatocytes in mice lacking the UBR2 ubiquitin ligase of the N-end rule pathway., Molecular and cellular biology, 2003, 23
  http://rdf.ncbi.nlm.nih.gov/pubmed/14585983

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• chromatin silencing
  http://purl.obolibrary.org/obo/GO_0006342
• ligase activity
  http://purl.obolibrary.org/obo/GO_0016874
• cellular response to leucine
  http://purl.obolibrary.org/obo/GO_0071233
• spermatogenesis
  http://purl.obolibrary.org/obo/GO_0007283
• plasma membrane
  http://purl.obolibrary.org/obo/GO_0005886
• histone H2A ubiquitination
  http://purl.obolibrary.org/obo/GO_0033522
• chromatin
  http://purl.obolibrary.org/obo/GO_0000785
• metal ion binding
  http://purl.obolibrary.org/obo/GO_0046872
• zinc ion binding
  http://purl.obolibrary.org/obo/GO_0008270
• nucleus
  http://purl.obolibrary.org/obo/GO_0005634
• negative regulation of TOR signaling
  http://purl.obolibrary.org/obo/GO_0032007
• ubiquitin-dependent protein catabolic process
  http://purl.obolibrary.org/obo/GO_0006511
• leucine binding
  http://purl.obolibrary.org/obo/GO_0070728
• protein binding
  http://purl.obolibrary.org/obo/GO_0005515
• male meiosis I
  http://purl.obolibrary.org/obo/GO_0007141
• protein catabolic process
  http://purl.obolibrary.org/obo/GO_0030163
• ubiquitin ligase complex
  http://purl.obolibrary.org/obo/GO_0000151

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName