CD00634

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD00634

CD00634

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Pde10a

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• phosphodiesterase 10A

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
• PDE10A2 brain-specific isoform
• phosphodiesterase 10A
• dual-substrate cAMP and cGMP, cyclic nucleotide phosphodiesterase

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• Pde10a3

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/23984

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• phosphodiesterase 10A
  http://metadb.riken.jp/db/mgi_rdf/MGI:1345143

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_011866

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000023868

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.87161

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=610652

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• Erik I. Charych, et.al., Interplay of palmitoylation and phosphorylation in the trafficking and localization of phosphodiesterase 10A: implications for the treatment of schizophrenia., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, 30
  http://rdf.ncbi.nlm.nih.gov/pubmed/20610737
• Robin J. Kleiman, et.al., Chronic suppression of phosphodiesterase 10A alters striatal expression of genes responsible for neurotransmitter synthesis, neurotransmission, and signaling pathways implicated in Huntington's disease., The Journal of pharmacology and experimental therapeutics, 2011, 336
  http://rdf.ncbi.nlm.nih.gov/pubmed/20923867
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• Haibei. Hu, et.al., Mutant huntingtin affects the rate of transcription of striatum-specific isoforms of phosphodiesterase 10A., The European journal of neuroscience, 2004, 20
  http://rdf.ncbi.nlm.nih.gov/pubmed/15610167
• Kenji. Omori, et.al., Overview of PDEs and their regulation., Circulation research, 2007, 100
  http://rdf.ncbi.nlm.nih.gov/pubmed/17307970
• Judith A. Siuciak, et.al., Genetic deletion of the striatum-enriched phosphodiesterase PDE10A: evidence for altered striatal function., Neuropharmacology, 2006, 51
  http://rdf.ncbi.nlm.nih.gov/pubmed/16769090
• S H. Soderling, et.al., Isolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A., Proceedings of the National Academy of Sciences of the United States of America, 1999, 96
  http://rdf.ncbi.nlm.nih.gov/pubmed/10359840
• A L O. Hebb, et.al., Striatal phosphodiesterase mRNA and protein levels are reduced in Huntington's disease transgenic mice prior to the onset of motor symptoms., Neuroscience, 2004, 123
  http://rdf.ncbi.nlm.nih.gov/pubmed/14751289
• Hiromi. Sano, et.al., Increased social interaction in mice deficient of the striatal medium spiny neuron-specific phosphodiesterase 10A2., Journal of neurochemistry, 2008, 105
  http://rdf.ncbi.nlm.nih.gov/pubmed/18088367
• Judith A. Siuciak, et.al., Behavioral characterization of mice deficient in the phosphodiesterase-10A (PDE10A) enzyme on a C57/Bl6N congenic background., Neuropharmacology, 2008, 54
  http://rdf.ncbi.nlm.nih.gov/pubmed/18061215

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• signal transduction
  http://purl.obolibrary.org/obo/GO_0007165
• hydrolase activity
  http://purl.obolibrary.org/obo/GO_0016787
• cAMP catabolic process
  http://purl.obolibrary.org/obo/GO_0006198
• drug binding
  http://purl.obolibrary.org/obo/GO_0008144
• cyclic-nucleotide phosphodiesterase activity
  http://purl.obolibrary.org/obo/GO_0004112
• perikaryon
  http://purl.obolibrary.org/obo/GO_0043204
• neuronal cell body
  http://purl.obolibrary.org/obo/GO_0043025
• cAMP binding
  http://purl.obolibrary.org/obo/GO_0030552
• cGMP binding
  http://purl.obolibrary.org/obo/GO_0030553
• metabolic process
  http://purl.obolibrary.org/obo/GO_0008152
• catalytic activity
  http://purl.obolibrary.org/obo/GO_0003824
• membrane fraction
  http://purl.obolibrary.org/obo/GO_0005624
• phosphoric diester hydrolase activity
  http://purl.obolibrary.org/obo/GO_0008081
• cGMP catabolic process
  http://purl.obolibrary.org/obo/GO_0046069
• nucleotide binding
  http://purl.obolibrary.org/obo/GO_0000166
• cytoplasm
  http://purl.obolibrary.org/obo/GO_0005737
• metal ion binding
  http://purl.obolibrary.org/obo/GO_0046872
• soluble fraction
  http://purl.obolibrary.org/obo/GO_0005625
• cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
  http://purl.obolibrary.org/obo/GO_0004118

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map00230

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Purine metabolism