CD00744

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD00744

CD00744

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Dio2

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• deiodinase, iodothyronine, type II

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• type II iodothyronine deiodinase
• type-II 5'-deiodinase
• iodothyronine type II deiodinase
• type 2 DI
• type-II 5' deiodinase
• deiodinase, iodothyronine, type II

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• 5DII
• AI324267
• 5DI
• DIOII

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/13371

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• deiodinase, iodothyronine, type II
  http://metadb.riken.jp/db/mgi_rdf/MGI:1338833

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_010050

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000007682

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.408815
• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.21389

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=601413

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• Wagner S. da-Silva, et.al., The chemical chaperones tauroursodeoxycholic and 4-phenylbutyric acid accelerate thyroid hormone activation and energy expenditure., FEBS letters, 2011, 585
  http://rdf.ncbi.nlm.nih.gov/pubmed/21237159
• A. Campos-Barros, et.al., Type 2 iodothyronine deiodinase expression in the cochlea before the onset of hearing., Proceedings of the National Academy of Sciences of the United States of America, 2000, 97
  http://rdf.ncbi.nlm.nih.gov/pubmed/10655523
• S. Song, et.al., Isolation and characterization of the 5'-upstream and untranslated regions of the mouse type II iodothyronine deiodinase gene., Molecular and cellular endocrinology, 2000, 165
  http://rdf.ncbi.nlm.nih.gov/pubmed/10940497
• Alessandro. Marsili, et.al., Type 2 iodothyronine deiodinase levels are higher in slow-twitch than fast-twitch mouse skeletal muscle and are increased in hypothyroidism., Endocrinology, 2010, 151
  http://rdf.ncbi.nlm.nih.gov/pubmed/20881246
• W. Croteau, et.al., Cloning of the mammalian type II iodothyronine deiodinase. A selenoprotein differentially expressed and regulated in human and rat brain and other tissues., The Journal of clinical investigation, 1996, 98
  http://rdf.ncbi.nlm.nih.gov/pubmed/8755651
• Monica. Dentice, et.al., The FoxO3/type 2 deiodinase pathway is required for normal mouse myogenesis and muscle regeneration., The Journal of clinical investigation, 2010, 120
  http://rdf.ncbi.nlm.nih.gov/pubmed/20978344
• L A. de Jesus, et.al., The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue., The Journal of clinical investigation, 2001, 108
  http://rdf.ncbi.nlm.nih.gov/pubmed/11696583
• A. Guadaño-Ferraz, et.al., The type 2 iodothyronine deiodinase is expressed primarily in glial cells in the neonatal rat brain., Proceedings of the National Academy of Sciences of the United States of America, 1997, 94
  http://rdf.ncbi.nlm.nih.gov/pubmed/9294221
• Jessica A. Hall, et.al., Absence of thyroid hormone activation during development underlies a permanent defect in adaptive thermogenesis., Endocrinology, 2010, 151
  http://rdf.ncbi.nlm.nih.gov/pubmed/20660060
• S. Song, et.al., Biochemical and molecular biological evidence for the presence of type II iodothyronine deiodinase in mouse mammary gland., Molecular and cellular endocrinology, 2000, 160
  http://rdf.ncbi.nlm.nih.gov/pubmed/10715551
• Matthew L. Rosene, et.al., Inhibition of the type 2 iodothyronine deiodinase underlies the elevated plasma TSH associated with amiodarone treatment., Endocrinology, 2010, 151
  http://rdf.ncbi.nlm.nih.gov/pubmed/20926587
• J C. Davey, et.al., Cloning of a 5.8 kb cDNA for a mouse type 2 deiodinase., Endocrinology, 1999, 140
  http://rdf.ncbi.nlm.nih.gov/pubmed/9927339

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• thyroid hormone catabolic process
  http://purl.obolibrary.org/obo/GO_0042404
• oxidation-reduction process
  http://purl.obolibrary.org/obo/GO_0055114
• thyroid hormone metabolic process
  http://purl.obolibrary.org/obo/GO_0042403
• thyroid-stimulating hormone secretion
  http://purl.obolibrary.org/obo/GO_0070460
• membrane
  http://purl.obolibrary.org/obo/GO_0016020
• response to cold
  http://purl.obolibrary.org/obo/GO_0009409
• cell
  http://purl.obolibrary.org/obo/GO_0005623
• integral component of membrane
  http://purl.obolibrary.org/obo/GO_0016021
• ubiquitin protein ligase binding
  http://purl.obolibrary.org/obo/GO_0031625
• oxidoreductase activity
  http://purl.obolibrary.org/obo/GO_0016491
• thyroid hormone generation
  http://purl.obolibrary.org/obo/GO_0006590
• hormone biosynthetic process
  http://purl.obolibrary.org/obo/GO_0042446

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName