CD01257

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD01257

CD01257

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Rims1

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• regulating synaptic membrane exocytosis 1

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• Rab3 interacting protein 1
• synaptic exocytosis regulator 1
• Rab3 effector
• rab3-interacting molecule 1
• rab-3-interacting molecule 1
• RIM 1
• rab3-interacting protein 1
• regulating synaptic membrane exocytosis protein 1
• rab-3-interacting protein 1
• regulating synaptic membrane exocytosis 1

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• Serg1
• mKIAA0340
• RIM1alpha
• C030033M19Rik
• RIM1
• Rab3ip1
• Rim
• RIM1a
• Rim1b

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/116837

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• regulating synaptic membrane exocytosis 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:2152971

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_001012623
• https://www.ncbi.nlm.nih.gov/nuccore/NM_001012625
• https://www.ncbi.nlm.nih.gov/nuccore/NM_183018
• https://www.ncbi.nlm.nih.gov/nuccore/NM_001012624
• https://www.ncbi.nlm.nih.gov/nuccore/NM_053270

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000041670

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.60061
• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.380549
• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.461684

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=606629

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• Susanne. Schoch, et.al., RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone., Nature, 2002, 415
  http://rdf.ncbi.nlm.nih.gov/pubmed/11797009
• T. Nagase, et.al., Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro., DNA research : an international journal for rapid publication of reports on genes and genomes, 1997, 4
  http://rdf.ncbi.nlm.nih.gov/pubmed/9205841
• Pascal S. Kaeser, et.al., RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction., Cell, 2011, 144
  http://rdf.ncbi.nlm.nih.gov/pubmed/21241895
• X. Wang, et.al., Rim1 and rabphilin-3 bind Rab3-GTP by composite determinants partially related through N-terminal alpha -helix motifs., The Journal of biological chemistry, 2001, 276
  http://rdf.ncbi.nlm.nih.gov/pubmed/11431472
• Pablo E. Castillo, et.al., RIM1alpha is required for presynaptic long-term potentiation., Nature, 2002, 415
  http://rdf.ncbi.nlm.nih.gov/pubmed/11797010
• Lunbin. Deng, et.al., RIM proteins activate vesicle priming by reversing autoinhibitory homodimerization of Munc13., Neuron, 2011, 69
  http://rdf.ncbi.nlm.nih.gov/pubmed/21262469
• Yunyun. Han, et.al., RIM determines Ca²+ channel density and vesicle docking at the presynaptic active zone., Neuron, 2011, 69
  http://rdf.ncbi.nlm.nih.gov/pubmed/21262468
• Brad A. Grueter, et.al., Postsynaptic TRPV1 triggers cell type-specific long-term depression in the nucleus accumbens., Nature neuroscience, 2010, 13
  http://rdf.ncbi.nlm.nih.gov/pubmed/21076424
• György. Lonart, RIM1: an edge for presynaptic plasticity., Trends in neurosciences, 2002, 25
  http://rdf.ncbi.nlm.nih.gov/pubmed/12079752
• N. Ozaki, et.al., cAMP-GEFII is a direct target of cAMP in regulated exocytosis., Nature cell biology, 2000, 2
  http://rdf.ncbi.nlm.nih.gov/pubmed/11056535
• Mitsunori. Fukuda, Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2., The Journal of biological chemistry, 2003, 278
  http://rdf.ncbi.nlm.nih.gov/pubmed/12578829

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• regulation of long-term neuronal synaptic plasticity
  http://purl.obolibrary.org/obo/GO_0048169
• neurotransmitter transport
  http://purl.obolibrary.org/obo/GO_0006836
• macromolecular complex assembly
  http://purl.obolibrary.org/obo/GO_0065003
• intracellular protein transport
  http://purl.obolibrary.org/obo/GO_0006886
• intracellular
  http://purl.obolibrary.org/obo/GO_0005622
• plasma membrane
  http://purl.obolibrary.org/obo/GO_0005886
• Rab GTPase binding
  http://purl.obolibrary.org/obo/GO_0017137
• presynaptic membrane
  http://purl.obolibrary.org/obo/GO_0042734
• exocytosis
  http://purl.obolibrary.org/obo/GO_0006887
• synapse
  http://purl.obolibrary.org/obo/GO_0045202
• SH3 domain binding
  http://purl.obolibrary.org/obo/GO_0017124
• transport
  http://purl.obolibrary.org/obo/GO_0006810
• protein kinase binding
  http://purl.obolibrary.org/obo/GO_0019901
• cell junction
  http://purl.obolibrary.org/obo/GO_0030054
• metal ion binding
  http://purl.obolibrary.org/obo/GO_0046872
• protein binding
  http://purl.obolibrary.org/obo/GO_0005515
• membrane
  http://purl.obolibrary.org/obo/GO_0016020

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map04721

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Synaptic vesicle cycle