CD02226

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD02226

CD02226

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Pde1b

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• phosphodiesterase 1B, Ca2+-calmodulin dependent

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• cam-PDE 1B
• phosphodiesterase 1B, Ca2+-calmodulin dependent
• 63 kDa Cam-PDE
• phosphodiesterase 1B, Ca2+-calmodulin dependent, 63 kDa
• calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
• phosphodiesterase 1B1, Ca2+-calmodulin dependent, 63 kDa

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• 63kDa
• Pde1b1

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/18574

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• phosphodiesterase 1B, Ca2+-calmodulin dependent
  http://metadb.riken.jp/db/mgi_rdf/MGI:97523

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_008800

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000022489

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.390792

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=171891

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• J A. Siuciak, et.al., Behavioral and neurochemical characterization of mice deficient in the phosphodiesterase-1B (PDE1B) enzyme., Neuropharmacology, 2007, 53
  http://rdf.ncbi.nlm.nih.gov/pubmed/17559891
• S. Spence, et.al., Receptor-mediated stimulation of lipid signalling pathways in CHO cells elicits the rapid transient induction of the PDE1B isoform of Ca2+/calmodulin-stimulated cAMP phosphodiesterase., The Biochemical journal, 1997, 321 ( Pt 1)
  http://rdf.ncbi.nlm.nih.gov/pubmed/9003415
• Tasmina A. Goraya, et.al., Kinetic properties of Ca2+/calmodulin-dependent phosphodiesterase isoforms dictate intracellular cAMP dynamics in response to elevation of cytosolic Ca2+., Cellular signalling, 2008, 20
  http://rdf.ncbi.nlm.nih.gov/pubmed/18335582
• Kenji. Omori, et.al., Overview of PDEs and their regulation., Circulation research, 2007, 100
  http://rdf.ncbi.nlm.nih.gov/pubmed/17307970
• Axel. Visel, et.al., Regulatory pathway analysis by high-throughput in situ hybridization., PLoS genetics, 2007, 3
  http://rdf.ncbi.nlm.nih.gov/pubmed/17953485
• C. Yan, et.al., Molecular cloning and characterization of a calmodulin-dependent phosphodiesterase enriched in olfactory sensory neurons., Proceedings of the National Academy of Sciences of the United States of America, 1995, 92
  http://rdf.ncbi.nlm.nih.gov/pubmed/7568196
• T M. Reed, et.al., Genomic structure and chromosome location of the murine PDE1B phosphodiesterase gene., Mammalian genome : official journal of the International Mammalian Genome Society, 1998, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/9657856
• D R. Repaske, et.al., A polymerase chain reaction strategy to identify and clone cyclic nucleotide phosphodiesterase cDNAs. Molecular cloning of the cDNA encoding the 63-kDa calmodulin-dependent phosphodiesterase., The Journal of biological chemistry, 1992, 267
  http://rdf.ncbi.nlm.nih.gov/pubmed/1326532
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• J W. Polli, et.al., Molecular cloning of DNA encoding a calmodulin-dependent phosphodiesterase enriched in striatum., Proceedings of the National Academy of Sciences of the United States of America, 1992, 89
  http://rdf.ncbi.nlm.nih.gov/pubmed/1332068

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• calmodulin binding
  http://purl.obolibrary.org/obo/GO_0005516
• cyclic-nucleotide phosphodiesterase activity
  http://purl.obolibrary.org/obo/GO_0004112
• cytoplasm
  http://purl.obolibrary.org/obo/GO_0005737
• cAMP catabolic process
  http://purl.obolibrary.org/obo/GO_0006198
• signal transduction
  http://purl.obolibrary.org/obo/GO_0007165
• nucleus
  http://purl.obolibrary.org/obo/GO_0005634
• serotonin metabolic process
  http://purl.obolibrary.org/obo/GO_0042428
• locomotory behavior
  http://purl.obolibrary.org/obo/GO_0007626
• regulation of neurotransmitter levels
  http://purl.obolibrary.org/obo/GO_0001505
• visual learning
  http://purl.obolibrary.org/obo/GO_0008542
• hydrolase activity
  http://purl.obolibrary.org/obo/GO_0016787
• metal ion binding
  http://purl.obolibrary.org/obo/GO_0046872
• regulation of dopamine metabolic process
  http://purl.obolibrary.org/obo/GO_0042053
• metabolic process
  http://purl.obolibrary.org/obo/GO_0008152
• phosphoric diester hydrolase activity
  http://purl.obolibrary.org/obo/GO_0008081
• cellular response to granulocyte macrophage colony-stimulating factor stimulus
  http://purl.obolibrary.org/obo/GO_0097011
• response to amphetamine
  http://purl.obolibrary.org/obo/GO_0001975
• calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
  http://purl.obolibrary.org/obo/GO_0004117
• catalytic activity
  http://purl.obolibrary.org/obo/GO_0003824
• cellular response to macrophage colony-stimulating factor stimulus
  http://purl.obolibrary.org/obo/GO_0036006
• cGMP catabolic process
  http://purl.obolibrary.org/obo/GO_0046069
• neuronal cell body
  http://purl.obolibrary.org/obo/GO_0043025

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map04020
• http://www.genome.jp/dbget-bin/www_bget?map00230

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Calcium signaling pathway
• Purine metabolism