CD02381

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD02381

CD02381

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Ahcy

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• S-adenosylhomocysteine hydrolase

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• adenosylhomocysteinase
• S-adenosylhomocysteine hydrolase
• S-adenosyl-L-homocysteine hydrolase
• adoHcyase
• liver copper-binding protein

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• AL024110
• CuBP
• SAHH
• AA987153

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/269378

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• S-adenosylhomocysteine hydrolase
  http://metadb.riken.jp/db/mgi_rdf/MGI:87968

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_016661

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000027597

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.330692
• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.371964

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=180960

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• Christine. Farrar, et.al., Altered levels of S-adenosylmethionine and S-adenosylhomocysteine in the brains of L-isoaspartyl (D-Aspartyl) O-methyltransferase-deficient mice., The Journal of biological chemistry, 2002, 277
  http://rdf.ncbi.nlm.nih.gov/pubmed/12023972
• M. Mehrabian, et.al., Genetic loci controlling body fat, lipoprotein metabolism, and insulin levels in a multifactorial mouse model., The Journal of clinical investigation, 1998, 101
  http://rdf.ncbi.nlm.nih.gov/pubmed/9616220
• M W. Miller, et.al., The mouse lethal nonagouti (a(x)) mutation deletes the S-adenosylhomocysteine hydrolase (Ahcy) gene., The EMBO journal, 1994, 13
  http://rdf.ncbi.nlm.nih.gov/pubmed/8168479
• K E. Bethin, et.al., Identification of a major hepatic copper binding protein as S-adenosylhomocysteine hydrolase., The Journal of biological chemistry, 1995, 270
  http://rdf.ncbi.nlm.nih.gov/pubmed/7657650
• A. Pilz, et.al., Mapping of the structural gene for S-adenosyl homocysteine hydrolase to mouse chromosome 2, and related sequences to chromosomes 8 and X., Mammalian genome : official journal of the International Mammalian Genome Society, 1992, 3
  http://rdf.ncbi.nlm.nih.gov/pubmed/1450513
• H C. Seo, et.al., Purification and properties of a self-associating, 50-kDa copper-binding protein from brindled mouse livers., The Journal of biological chemistry, 1993, 268
  http://rdf.ncbi.nlm.nih.gov/pubmed/8419320
• Thomas B. Shea, et.al., The S-adenosyl homocysteine hydrolase inhibitor 3-deaza-adenosine prevents oxidative damage and cognitive impairment following folate and vitamin E deprivation in a murine model of age-related, oxidative stress-induced neurodegeneration., Neuromolecular medicine, 2004, 5
  http://rdf.ncbi.nlm.nih.gov/pubmed/15075443
• Masaaki. Ishihara, et.al., Crystallization of mouse S-adenosyl-L-homocysteine hydrolase., Acta crystallographica. Section F, Structural biology and crystallization communications, 2010, 66
  http://rdf.ncbi.nlm.nih.gov/pubmed/20208169
• Traci L. Pawlowski, et.al., Candidate Agtr2 influenced genes and pathways identified by expression profiling in the developing brain of Agtr2(-/y) mice., Genomics, 2009, 94
  http://rdf.ncbi.nlm.nih.gov/pubmed/19501643
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• T. Leeb, et.al., Characterization and chromosome assignment of the porcine AHCY gene for S-adenosylhomocysteine hydrolase., Cytogenetic and genome research, 2002, 97
  http://rdf.ncbi.nlm.nih.gov/pubmed/12438749
• Maria Elena. Fernandez-Sanchez, et.al., S-adenosyl homocysteine hydrolase is required for Myc-induced mRNA cap methylation, protein synthesis, and cell proliferation., Molecular and cellular biology, 2009, 29
  http://rdf.ncbi.nlm.nih.gov/pubmed/19805518
• Siming. Li, et.al., Regulation of homocysteine homeostasis through the transcriptional coactivator PGC-1alpha., American journal of physiology. Endocrinology and metabolism, 2009, 296
  http://rdf.ncbi.nlm.nih.gov/pubmed/19158324

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• cytosol
  http://purl.obolibrary.org/obo/GO_0005829
• identical protein binding
  http://purl.obolibrary.org/obo/GO_0042802
• NAD binding
  http://purl.obolibrary.org/obo/GO_0051287
• S-adenosylhomocysteine catabolic process
  http://purl.obolibrary.org/obo/GO_0019510
• protein self-association
  http://purl.obolibrary.org/obo/GO_0043621
• circadian sleep/wake cycle
  http://purl.obolibrary.org/obo/GO_0042745
• chronic inflammatory response to antigenic stimulus
  http://purl.obolibrary.org/obo/GO_0002439
• adenyl nucleotide binding
  http://purl.obolibrary.org/obo/GO_0030554
• synaptosome
  http://purl.obolibrary.org/obo/GO_0019717
• adenosylhomocysteinase activity
  http://purl.obolibrary.org/obo/GO_0004013
• copper ion binding
  http://purl.obolibrary.org/obo/GO_0005507
• NAD+ binding
  http://purl.obolibrary.org/obo/GO_0070403
• nucleus
  http://purl.obolibrary.org/obo/GO_0005634
• response to nutrient
  http://purl.obolibrary.org/obo/GO_0007584

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map01100
• http://www.genome.jp/dbget-bin/www_bget?map00270

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Metabolic pathways
• Cysteine and methionine metabolism