CD02421

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD02421

CD02421

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Ptpn5

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• protein tyrosine phosphatase, non-receptor type 5

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• neural-specific protein-tyrosine phosphatase
• striatum-enriched protein-tyrosine phosphatase
• protein tyrosine phosphatase, non-receptor type 5
• tyrosine-protein phosphatase non-receptor type 5

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• Step

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/19259

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• protein tyrosine phosphatase, non-receptor type 5
  http://metadb.riken.jp/db/mgi_rdf/MGI:97807

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_013643
• https://www.ncbi.nlm.nih.gov/nuccore/NM_001163565

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000030854

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.4654

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=176879

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• A. Bult, et.al., STEP: a family of brain-enriched PTPs. Alternative splicing produces transmembrane, cytosolic and truncated isoforms., European journal of cell biology, 1997, 72
  http://rdf.ncbi.nlm.nih.gov/pubmed/9127733
• Pradeep. Kurup, et.al., Abeta-mediated NMDA receptor endocytosis in Alzheimer's disease involves ubiquitination of the tyrosine phosphatase STEP61., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, 30
  http://rdf.ncbi.nlm.nih.gov/pubmed/20427654
• Y. Kaneko, et.al., Identification of protein tyrosine phosphatases expressed in murine male germ cells., Biochemical and biophysical research communications, 1993, 197
  http://rdf.ncbi.nlm.nih.gov/pubmed/8267598
• X. Li, et.al., Molecular cloning of the human homolog of a striatum-enriched phosphatase (STEP) gene and chromosomal mapping of the human and murine loci., Genomics, 1995, 28
  http://rdf.ncbi.nlm.nih.gov/pubmed/7490079
• A. Bult, et.al., STEP61: a member of a family of brain-enriched PTPs is localized to the endoplasmic reticulum., The Journal of neuroscience : the official journal of the Society for Neuroscience, 1996, 16
  http://rdf.ncbi.nlm.nih.gov/pubmed/8987810
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• E. Sharma, et.al., Identification of two alternatively spliced transcripts of STEP: a subfamily of brain-enriched protein tyrosine phosphatases., Brain research. Molecular brain research, 1995, 32
  http://rdf.ncbi.nlm.nih.gov/pubmed/7494467
• Jian. Xu, et.al., Extrasynaptic NMDA receptors couple preferentially to excitotoxicity via calpain-mediated cleavage of STEP., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, 29
  http://rdf.ncbi.nlm.nih.gov/pubmed/19625523
• Deepa V. Venkitaramani, et.al., Knockout of striatal enriched protein tyrosine phosphatase in mice results in increased ERK1/2 phosphorylation., Synapse (New York, N.Y.), 2009, 63
  http://rdf.ncbi.nlm.nih.gov/pubmed/18932218
• Yongfang. Zhang, et.al., Genetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive and cellular deficits in an Alzheimer's disease mouse model., Proceedings of the National Academy of Sciences of the United States of America, 2010, 107
  http://rdf.ncbi.nlm.nih.gov/pubmed/20956308

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• protein dephosphorylation
  http://purl.obolibrary.org/obo/GO_0006470
• phosphatase activity
  http://purl.obolibrary.org/obo/GO_0016791
• phosphotyrosine binding
  http://purl.obolibrary.org/obo/GO_0001784
• phosphoprotein phosphatase activity
  http://purl.obolibrary.org/obo/GO_0004721
• dephosphorylation
  http://purl.obolibrary.org/obo/GO_0016311
• hydrolase activity
  http://purl.obolibrary.org/obo/GO_0016787
• peptidyl-tyrosine dephosphorylation
  http://purl.obolibrary.org/obo/GO_0035335
• protein tyrosine phosphatase activity
  http://purl.obolibrary.org/obo/GO_0004725

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map04010

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• MAPK signaling pathway