CD02423

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD02423

CD02423

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Cbr1

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• carbonyl reductase 1

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• prostaglandin-E(2) 9-reductase
• carbonyl reductase 1
• prostaglandin 9-ketoreductase
• carbonyl reductase [NADPH] 1
• Carbonyl reductase [NADPH] 1 (NADPH-dependent carbonyl reductase 1)
• NADPH-dependent carbonyl reductase 1
• 15-hydroxyprostaglandin dehydrogenase

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• AW261796
• Cbr
• CR

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/12408

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• carbonyl reductase 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:88284

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_007620

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000051483

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.26940

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=114830

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• M. Nakanishi, et.al., Involvement of two basic residues (Lys-17 and Arg-39) of mouse lung carbonyl reductase in NADP(H)-binding and fatty acid activation: site-directed mutagenesis and kinetic analyses., Journal of biochemistry, 1996, 120
  http://rdf.ncbi.nlm.nih.gov/pubmed/8889808
• M A. Rashid, et.al., Carbonyl reductase 1 protects pancreatic β-cells against oxidative stress-induced apoptosis in glucotoxicity and glucolipotoxicity., Free radical biology & medicine, 2010, 49
  http://rdf.ncbi.nlm.nih.gov/pubmed/20728534
• A E. Mjaatvedt, et.al., Assessment of a mutation in the H5 domain of Girk2 as a candidate for the weaver mutation., Genome research, 1995, 5
  http://rdf.ncbi.nlm.nih.gov/pubmed/8808466
• J. Wei, et.al., Cloning a cDNA for carbonyl reductase (Cbr) from mouse cerebellum: murine genes that express cbr map to chromosomes 16 and 11., Genomics, 1996, 34
  http://rdf.ncbi.nlm.nih.gov/pubmed/8661038
• S. Brookes, et.al., Localization of four human chromosome 21 genes--SOD1, ETS2, IFNAR, and CBR--to two different chromosomes in the marsupial species Macropus eugenii., Cytogenetics and cell genetics, 1992, 61
  http://rdf.ncbi.nlm.nih.gov/pubmed/1380419
• L E. Olson, et.al., A chromosome 21 critical region does not cause specific Down syndrome phenotypes., Science (New York, N.Y.), 2004, 306
  http://rdf.ncbi.nlm.nih.gov/pubmed/15499018
• A E. Mjaatvedt, et.al., High-resolution mapping of D16led-1, Gart, Gas-4, Cbr, Pcp-4, and Erg on distal mouse chromosome 16., Genomics, 1993, 17
  http://rdf.ncbi.nlm.nih.gov/pubmed/8406490
• Lisa E. Olson, et.al., Protection from doxorubicin-induced cardiac toxicity in mice with a null allele of carbonyl reductase 1., Cancer research, 2003, 63
  http://rdf.ncbi.nlm.nih.gov/pubmed/14583452
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• Zohra. Sérégaza, et.al., Mouse models of cognitive disorders in trisomy 21: a review., Behavior genetics, 2006, 36
  http://rdf.ncbi.nlm.nih.gov/pubmed/16523244
• Yorick. Gitton, et.al., A gene expression map of human chromosome 21 orthologues in the mouse., Nature, 2002, 420
  http://rdf.ncbi.nlm.nih.gov/pubmed/12466855

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• oxidoreductase activity
  http://purl.obolibrary.org/obo/GO_0016491
• phylloquinone catabolic process
  http://purl.obolibrary.org/obo/GO_0042376
• nucleotide binding
  http://purl.obolibrary.org/obo/GO_0000166
• nucleus
  http://purl.obolibrary.org/obo/GO_0005634
• oxidation-reduction process
  http://purl.obolibrary.org/obo/GO_0055114
• prostaglandin-E2 9-reductase activity
  http://purl.obolibrary.org/obo/GO_0050221
• 15-hydroxyprostaglandin dehydrogenase (NADP+) activity
  http://purl.obolibrary.org/obo/GO_0047021
• microsome
  http://purl.obolibrary.org/obo/GO_0005792
• cytoplasm
  http://purl.obolibrary.org/obo/GO_0005737
• plasma membrane
  http://purl.obolibrary.org/obo/GO_0005886
• vitamin K metabolic process
  http://purl.obolibrary.org/obo/GO_0042373
• metabolic process
  http://purl.obolibrary.org/obo/GO_0008152
• carbonyl reductase (NADPH) activity
  http://purl.obolibrary.org/obo/GO_0004090
• drug metabolic process
  http://purl.obolibrary.org/obo/GO_0017144
• microvillus
  http://purl.obolibrary.org/obo/GO_0005902

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map00980
• http://www.genome.jp/dbget-bin/www_bget?map01100
• http://www.genome.jp/dbget-bin/www_bget?map00590

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Metabolic pathways
• Arachidonic acid metabolism
• Metabolism of xenobiotics by cytochrome P450