CD02600

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD02600

CD02600

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Srebf1

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• sterol regulatory element binding transcription factor 1

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• adipocyte determination- and differentiation-dependent factor 1
• sterol regulatory element binding transcription factor 1
• sterol regulatory element-binding protein 1

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• SREBP-1a
• SREBP1
• ADD-1
• D630008H06
• SREBP1c
• SREBP-1c
• ADD1
• bHLHd1
• SREBP-1

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/20787

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• sterol regulatory element binding transcription factor 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:107606

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_011480

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000020538

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.296366
• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.278701

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=184756

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• Mototsugu. Takashima, et.al., Regulation of SREBP1c expression by mTOR signaling in hepatocytes., The Kobe journal of medical sciences, 2009, 55
  http://rdf.ncbi.nlm.nih.gov/pubmed/20847591
• http://rdf.ncbi.nlm.nih.gov/pubmed/12180145
• I. Shimomura, et.al., Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells., The Journal of clinical investigation, 1997, 99
  http://rdf.ncbi.nlm.nih.gov/pubmed/9062340
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• K. Rooke, et.al., Mapping of the gene for calreticulin (Calr) to mouse chromosome 8., Mammalian genome : official journal of the International Mammalian Genome Society, 1997, 8
  http://rdf.ncbi.nlm.nih.gov/pubmed/9337407
• Jorg. Kotzka, et.al., Phosphorylation of sterol regulatory element-binding protein (SREBP)-1a links growth hormone action to lipid metabolism in hepatocytes., Atherosclerosis, 2010, 213
  http://rdf.ncbi.nlm.nih.gov/pubmed/20863500
• Takatoshi. Murase, et.al., Coffee polyphenols suppress diet-induced body fat accumulation by downregulating SREBP-1c and related molecules in C57BL/6J mice., American journal of physiology. Endocrinology and metabolism, 2011, 300
  http://rdf.ncbi.nlm.nih.gov/pubmed/20943752
• H. Shimano, et.al., Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene., The Journal of clinical investigation, 1997, 100
  http://rdf.ncbi.nlm.nih.gov/pubmed/9329978
• H. Shimano, et.al., Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a., The Journal of clinical investigation, 1996, 98
  http://rdf.ncbi.nlm.nih.gov/pubmed/8833906
• Bhaskar. Ponugoti, et.al., SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism., The Journal of biological chemistry, 2010, 285
  http://rdf.ncbi.nlm.nih.gov/pubmed/20817729
• C L. Welch, et.al., Genetic regulation of cholesterol homeostasis: chromosomal organization of candidate genes., Journal of lipid research, 1996, 37
  http://rdf.ncbi.nlm.nih.gov/pubmed/8827514

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• positive regulation of triglyceride biosynthetic process
  http://purl.obolibrary.org/obo/GO_0010867
• negative regulation of insulin secretion
  http://purl.obolibrary.org/obo/GO_0046676
• insulin receptor signaling pathway
  http://purl.obolibrary.org/obo/GO_0008286
• regulation of insulin secretion
  http://purl.obolibrary.org/obo/GO_0050796
• steroid metabolic process
  http://purl.obolibrary.org/obo/GO_0008202
• macromolecular complex
  http://purl.obolibrary.org/obo/GO_0032991
• positive regulation of cholesterol biosynthetic process
  http://purl.obolibrary.org/obo/GO_0045542
• DNA binding
  http://purl.obolibrary.org/obo/GO_0003677
• response to glucose
  http://purl.obolibrary.org/obo/GO_0009749
• cytoplasm
  http://purl.obolibrary.org/obo/GO_0005737
• chromatin binding
  http://purl.obolibrary.org/obo/GO_0003682
• positive regulation of transcription from RNA polymerase II promoter
  http://purl.obolibrary.org/obo/GO_0045944
• cellular response to starvation
  http://purl.obolibrary.org/obo/GO_0009267
• microsome
  http://purl.obolibrary.org/obo/GO_0005792
• negative regulation of transcription from RNA polymerase II promoter
  http://purl.obolibrary.org/obo/GO_0000122
• sterol response element binding
  http://purl.obolibrary.org/obo/GO_0032810
• cholesterol metabolic process
  http://purl.obolibrary.org/obo/GO_0008203
• lipid biosynthetic process
  http://purl.obolibrary.org/obo/GO_0008610
• protein binding
  http://purl.obolibrary.org/obo/GO_0005515
• nucleus
  http://purl.obolibrary.org/obo/GO_0005634
• membrane
  http://purl.obolibrary.org/obo/GO_0016020
• positive regulation of histone deacetylation
  http://purl.obolibrary.org/obo/GO_0031065
• macromolecular complex binding
  http://purl.obolibrary.org/obo/GO_0044877
• sequence-specific DNA binding
  http://purl.obolibrary.org/obo/GO_0043565
• positive regulation of transcription, DNA-templated
  http://purl.obolibrary.org/obo/GO_0045893
• lipid metabolic process
  http://purl.obolibrary.org/obo/GO_0006629
• cytoplasmic part
  http://purl.obolibrary.org/obo/GO_0044444
• endoplasmic reticulum
  http://purl.obolibrary.org/obo/GO_0005783
• protein kinase binding
  http://purl.obolibrary.org/obo/GO_0019901
• regulation of heart rate by chemical signal
  http://purl.obolibrary.org/obo/GO_0003062
• regulation of fatty acid metabolic process
  http://purl.obolibrary.org/obo/GO_0019217
• positive regulation of fatty acid biosynthetic process
  http://purl.obolibrary.org/obo/GO_0045723
• integral component of membrane
  http://purl.obolibrary.org/obo/GO_0016021
• regulation of transcription, DNA-templated
  http://purl.obolibrary.org/obo/GO_0006355
• transcription, DNA-templated
  http://purl.obolibrary.org/obo/GO_0006351
• cytoplasmic vesicle
  http://purl.obolibrary.org/obo/GO_0031410
• sequence-specific DNA binding transcription factor activity
  http://purl.obolibrary.org/obo/GO_0003700
• SREBP signaling pathway
  http://purl.obolibrary.org/obo/GO_0032933
• Golgi apparatus
  http://purl.obolibrary.org/obo/GO_0005794

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map04910

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Insulin signaling pathway