CD02831

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD02831

CD02831

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Baiap2

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• brain-specific angiogenesis inhibitor 1-associated protein 2

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• BAI-associated protein 2
• insulin receptor substrate protein of 53 kDa
• insulin receptor tyrosine kinase 53 kDa substrate
• BAI1-associated protein 2
• brain-specific angiogenesis inhibitor 1-associated protein 2
• insulin receptor substrate p53

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• IRSp53
• R75030

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/108100

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• brain-specific angiogenesis inhibitor 1-associated protein 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:2137336

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_130862
• https://www.ncbi.nlm.nih.gov/nuccore/NM_001037755
• https://www.ncbi.nlm.nih.gov/nuccore/NM_001037754

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000025372

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.197534

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=605475

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• Doug. Stryke, et.al., BayGenomics: a resource of insertional mutations in mouse embryonic stem cells., Nucleic acids research, 2003, 31
  http://rdf.ncbi.nlm.nih.gov/pubmed/12520002
• Atsushi. Miyahara, et.al., Genomic structure and alternative splicing of the insulin receptor tyrosine kinase substrate of 53-kDa protein., Journal of human genetics, 2003, 48
  http://rdf.ncbi.nlm.nih.gov/pubmed/12884081
• P-S. Liu, et.al., The interplay between Eps8 and IRSp53 contributes to Src-mediated transformation., Oncogene, 2010, 29
  http://rdf.ncbi.nlm.nih.gov/pubmed/20418908
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• Bharesh K. Chauhan, et.al., Cdc42- and IRSp53-dependent contractile filopodia tether presumptive lens and retina to coordinate epithelial invagination., Development (Cambridge, England), 2009, 136
  http://rdf.ncbi.nlm.nih.gov/pubmed/19820184
• K. Oda, et.al., Identification of BAIAP2 (BAI-associated protein 2), a novel human homologue of hamster IRSp53, whose SH3 domain interacts with the cytoplasmic domain of BAI1., Cytogenetics and cell genetics, 1999, 84
  http://rdf.ncbi.nlm.nih.gov/pubmed/10343108
• T. Fujiwara, et.al., Rho small G-protein-dependent binding of mDia to an Src homology 3 domain-containing IRSp53/BAIAP2., Biochemical and biophysical research communications, 2000, 271
  http://rdf.ncbi.nlm.nih.gov/pubmed/10814512
• D Gregg. Rokosh, et.al., Knockout of the alpha 1A/C-adrenergic receptor subtype: the alpha 1A/C is expressed in resistance arteries and is required to maintain arterial blood pressure., Proceedings of the National Academy of Sciences of the United States of America, 2002, 99
  http://rdf.ncbi.nlm.nih.gov/pubmed/12093905
• H. Miki, et.al., IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling., Nature, 2000, 408
  http://rdf.ncbi.nlm.nih.gov/pubmed/11130076
• Carlos E. Alvarez, et.al., Novel isoform of insulin receptor substrate p53/p58 is generated by alternative splicing in the CRIB/SH3-binding region., The Journal of biological chemistry, 2002, 277
  http://rdf.ncbi.nlm.nih.gov/pubmed/12006592
• Jeffrey M. Robens, et.al., Regulation of IRSp53-dependent filopodial dynamics by antagonism between 14-3-3 binding and SH3-mediated localization., Molecular and cellular biology, 2010, 30
  http://rdf.ncbi.nlm.nih.gov/pubmed/19933840
• E A. Thomas, et.al., Insulin receptor substrate protein p53 localization in rats suggests mechanism for specific polyglutamine neurodegeneration., Neuroscience letters, 2001, 309
  http://rdf.ncbi.nlm.nih.gov/pubmed/11514062
• Soumitra. Rajagopal, et.al., Scaffold proteins IRSp53 and spinophilin regulate localized Rac activation by T-lymphocyte invasion and metastasis protein 1 (TIAM1)., The Journal of biological chemistry, 2010, 285
  http://rdf.ncbi.nlm.nih.gov/pubmed/20360004

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• cytoskeleton
  http://purl.obolibrary.org/obo/GO_0005856
• cell projection
  http://purl.obolibrary.org/obo/GO_0042995
• SH3 domain binding
  http://purl.obolibrary.org/obo/GO_0017124
• filopodium assembly
  http://purl.obolibrary.org/obo/GO_0046847
• regulation of actin cytoskeleton organization
  http://purl.obolibrary.org/obo/GO_0032956
• protein binding
  http://purl.obolibrary.org/obo/GO_0005515
• response to bacterium
  http://purl.obolibrary.org/obo/GO_0009617
• membrane
  http://purl.obolibrary.org/obo/GO_0016020
• nucleus
  http://purl.obolibrary.org/obo/GO_0005634
• cytoskeletal adaptor activity
  http://purl.obolibrary.org/obo/GO_0008093
• proline-rich region binding
  http://purl.obolibrary.org/obo/GO_0070064
• signal transduction
  http://purl.obolibrary.org/obo/GO_0007165
• cytoplasm
  http://purl.obolibrary.org/obo/GO_0005737
• Rho protein signal transduction
  http://purl.obolibrary.org/obo/GO_0007266
• cytosol
  http://purl.obolibrary.org/obo/GO_0005829
• cell junction
  http://purl.obolibrary.org/obo/GO_0030054
• intracellular
  http://purl.obolibrary.org/obo/GO_0005622
• plasma membrane
  http://purl.obolibrary.org/obo/GO_0005886

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map04810
• http://www.genome.jp/dbget-bin/www_bget?map04520

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Adherens junction
• Regulation of actin cytoskeleton