CD02954

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD02954

CD02954

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Dusp1

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• dual specificity phosphatase 1

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• mitogen-activated protein kinase phosphatase 1
• protein tyrosine phosphatase, non-receptor type 16
• protein-tyrosine phosphatase ERP
• MAP kinase phosphatase 1
• mitogen-activated protein kinase phosphatase-1
• dual specificity protein phosphatase 1
• protein-tyrosine phosphatase 3CH134
• dual specificity phosphatase 1

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• mkp-1
• MKP1
• 3CH134
• erp
• Ptpn16
• U19515

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/19252

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• dual specificity phosphatase 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:105120

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_013642

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000024190

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.239041

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=600714

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• W R. Schwan, et.al., Detection and characterization by differential PCR of host eukaryotic cell genes differentially transcribed following uptake of intracellular bacteria., Infection and immunity, 1996, 64
  http://rdf.ncbi.nlm.nih.gov/pubmed/8557379
• H. Sun, et.al., MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo., Cell, 1993, 75
  http://rdf.ncbi.nlm.nih.gov/pubmed/8221888
• Vanja. Duric, et.al., A negative regulator of MAP kinase causes depressive behavior., Nature medicine, 2010, 16
  http://rdf.ncbi.nlm.nih.gov/pubmed/20953200
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• U. Boschert, et.al., Regulated expression of dual specificity protein phosphatases in rat brain., Neuroreport, 1998, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/9926851
• Qing-Yuan. Zhu, et.al., MicroRNA-101 targets MAPK phosphatase-1 to regulate the activation of MAPKs in macrophages., Journal of immunology (Baltimore, Md. : 1950), 2010, 185
  http://rdf.ncbi.nlm.nih.gov/pubmed/21068409
• C H. Charles, et.al., cDNA sequence of a growth factor-inducible immediate early gene and characterization of its encoded protein., Oncogene, 1992, 7
  http://rdf.ncbi.nlm.nih.gov/pubmed/1741163
• Kristin M. Shields, et.al., Mitogen-activated protein kinase phosphatase-1 is a key regulator of hypoxia-induced vascular endothelial growth factor expression and vessel density in lung., The American journal of pathology, 2011, 178
  http://rdf.ncbi.nlm.nih.gov/pubmed/21224048
• D. Carrasco, et.al., Expression of the nontransmembrane tyrosine phosphatase gene erp during mouse organogenesis., Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 1993, 4
  http://rdf.ncbi.nlm.nih.gov/pubmed/8274454
• Upinder S. Bhalla, et.al., MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network., Science (New York, N.Y.), 2002, 297
  http://rdf.ncbi.nlm.nih.gov/pubmed/12169734
• T. Noguchi, et.al., Structure, mapping, and expression of erp, a growth factor-inducible gene encoding a nontransmembrane protein tyrosine phosphatase, and effect of ERP on cell growth., Molecular and cellular biology, 1993, 13
  http://rdf.ncbi.nlm.nih.gov/pubmed/8355678
• Freddy. Jeanneteau, et.al., The MAP kinase phosphatase MKP-1 regulates BDNF-induced axon branching., Nature neuroscience, 2010, 13
  http://rdf.ncbi.nlm.nih.gov/pubmed/20935641

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• MAP kinase tyrosine/serine/threonine phosphatase activity
  http://purl.obolibrary.org/obo/GO_0017017
• nucleoplasm
  http://purl.obolibrary.org/obo/GO_0005654
• endoderm formation
  http://purl.obolibrary.org/obo/GO_0001706
• dephosphorylation
  http://purl.obolibrary.org/obo/GO_0016311
• protein dephosphorylation
  http://purl.obolibrary.org/obo/GO_0006470
• hydrolase activity
  http://purl.obolibrary.org/obo/GO_0016787
• nucleus
  http://purl.obolibrary.org/obo/GO_0005634
• positive regulation of apoptotic process
  http://purl.obolibrary.org/obo/GO_0043065
• protein tyrosine/threonine phosphatase activity
  http://purl.obolibrary.org/obo/GO_0008330
• protein tyrosine/serine/threonine phosphatase activity
  http://purl.obolibrary.org/obo/GO_0008138
• soluble fraction
  http://purl.obolibrary.org/obo/GO_0005625
• regulation of apoptotic process
  http://purl.obolibrary.org/obo/GO_0042981
• peptidyl-tyrosine dephosphorylation
  http://purl.obolibrary.org/obo/GO_0035335
• protein tyrosine phosphatase activity
  http://purl.obolibrary.org/obo/GO_0004725
• intracellular signal transduction
  http://purl.obolibrary.org/obo/GO_0035556
• phosphatase activity
  http://purl.obolibrary.org/obo/GO_0016791
• inactivation of MAPK activity
  http://purl.obolibrary.org/obo/GO_0000188
• positive regulation of anti-apoptosis
  http://purl.obolibrary.org/obo/GO_0045768
• cell cycle
  http://purl.obolibrary.org/obo/GO_0007049
• phosphoprotein phosphatase activity
  http://purl.obolibrary.org/obo/GO_0004721

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map04010

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• MAPK signaling pathway