CD03106

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD03106

CD03106

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Bad

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• BCL2-associated agonist of cell death

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• BCL2-associated agonist of cell death
• Bcl-associated death promoter
• bcl-2-binding component 6
• bcl-xL/Bcl-2-associated death promoter
• bcl2 antagonist of cell death

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• AI325008
• BCL2L8
• Bbc2

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/12015

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• BCL2-associated agonist of cell death
  http://metadb.riken.jp/db/mgi_rdf/MGI:1096330

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_007522

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000024959

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.4387

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=603167

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• Shaynoor. Dramsi, et.al., Identification of a novel phosphorylation site, Ser-170, as a regulator of bad pro-apoptotic activity., The Journal of biological chemistry, 2002, 277
  http://rdf.ncbi.nlm.nih.gov/pubmed/11717309
• Yoshiyuki. Konishi, et.al., Cdc2 phosphorylation of BAD links the cell cycle to the cell death machinery., Molecular cell, 2002, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/12049737
• Nicole. Donovan, et.al., JNK phosphorylation and activation of BAD couples the stress-activated signaling pathway to the cell death machinery., The Journal of biological chemistry, 2002, 277
  http://rdf.ncbi.nlm.nih.gov/pubmed/12189144
• Julie. Quoyer, et.al., GLP-1 mediates antiapoptotic effect by phosphorylating Bad through a beta-arrestin 1-mediated ERK1/2 activation in pancreatic beta-cells., The Journal of biological chemistry, 2010, 285
  http://rdf.ncbi.nlm.nih.gov/pubmed/19915011
• Anna. Frenzel, et.al., Suppression of B-cell lymphomagenesis by the BH3-only proteins Bmf and Bad., Blood, 2010, 115
  http://rdf.ncbi.nlm.nih.gov/pubmed/19965635
• P N. Kelly, et.al., Individual and overlapping roles of BH3-only proteins Bim and Bad in apoptosis of lymphocytes and platelets and in suppression of thymic lymphoma development., Cell death and differentiation, 2010, 17
  http://rdf.ncbi.nlm.nih.gov/pubmed/20431598
他7件を見る
• Antonio F. Santidrián, et.al., AICAR induces apoptosis independently of AMPK and p53 through up-regulation of the BH3-only proteins BIM and NOXA in chronic lymphocytic leukemia cells., Blood, 2010, 116
  http://rdf.ncbi.nlm.nih.gov/pubmed/20664053
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• E. Yang, et.al., Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death., Cell, 1995, 80
  http://rdf.ncbi.nlm.nih.gov/pubmed/7834748
• S P. Tzung, et.al., Expression of Bcl-2 family during liver regeneration and identification of Bcl-x as a delayed early response gene., The American journal of pathology, 1997, 150
  http://rdf.ncbi.nlm.nih.gov/pubmed/9176392
• M. Moser, et.al., Enhanced apoptotic cell death of renal epithelial cells in mice lacking transcription factor AP-2beta., Genes & development, 1997, 11
  http://rdf.ncbi.nlm.nih.gov/pubmed/9271117
• A. Kelekar, et.al., Bad is a BH3 domain-containing protein that forms an inactivating dimer with Bcl-XL., Molecular and cellular biology, 1997, 17
  http://rdf.ncbi.nlm.nih.gov/pubmed/9372935
• L. del Peso, et.al., Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt., Science (New York, N.Y.), 1997, 278
  http://rdf.ncbi.nlm.nih.gov/pubmed/9381178

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• protein binding
  http://purl.obolibrary.org/obo/GO_0005515
• phospholipid binding
  http://purl.obolibrary.org/obo/GO_0005543
• cytoplasm
  http://purl.obolibrary.org/obo/GO_0005737
• mitochondrion
  http://purl.obolibrary.org/obo/GO_0005739
• mitochondrial outer membrane
  http://purl.obolibrary.org/obo/GO_0005741
• cytosol
  http://purl.obolibrary.org/obo/GO_0005829
他39件を見る
• glucose catabolic process
  http://purl.obolibrary.org/obo/GO_0006007
• lipid binding
  http://purl.obolibrary.org/obo/GO_0006630
• apoptotic process
  http://purl.obolibrary.org/obo/GO_0006915
• activation of cysteine-type endopeptidase activity involved in apoptotic process
  http://purl.obolibrary.org/obo/GO_0006919
• cell proliferation
  http://purl.obolibrary.org/obo/GO_0008283
• lipid binding
  http://purl.obolibrary.org/obo/GO_0008289
• activation of pro-apoptotic gene products
  http://purl.obolibrary.org/obo/GO_0008633
• cysteine-type endopeptidase activator activity involved in apoptotic process
  http://purl.obolibrary.org/obo/GO_0008656
• positive regulation of mitochondrial membrane potential
  http://purl.obolibrary.org/obo/GO_0010918
• membrane
  http://purl.obolibrary.org/obo/GO_0016020
• cytokine-mediated signaling pathway
  http://purl.obolibrary.org/obo/GO_0019221
• protein kinase binding
  http://purl.obolibrary.org/obo/GO_0019901
• protein phosphatase binding
  http://purl.obolibrary.org/obo/GO_0019903
• protein phosphatase 2B binding
  http://purl.obolibrary.org/obo/GO_0030346
• positive regulation of insulin secretion
  http://purl.obolibrary.org/obo/GO_0032024
• positive regulation of glucokinase activity
  http://purl.obolibrary.org/obo/GO_0033133
• positive regulation of insulin secretion involved in cellular response to glucose stimulus
  http://purl.obolibrary.org/obo/GO_0035774
• glucose homeostasis
  http://purl.obolibrary.org/obo/GO_0042593
• regulation of apoptotic process
  http://purl.obolibrary.org/obo/GO_0042981
• positive regulation of apoptotic process
  http://purl.obolibrary.org/obo/GO_0043065
• positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
  http://purl.obolibrary.org/obo/GO_0043280
• regulation of cysteine-type endopeptidase activity involved in apoptotic process
  http://purl.obolibrary.org/obo/GO_0043281
• protein kinase B binding
  http://purl.obolibrary.org/obo/GO_0043422
• type B pancreatic cell proliferation
  http://purl.obolibrary.org/obo/GO_0044342
• positive regulation of B cell differentiation
  http://purl.obolibrary.org/obo/GO_0045579
• positive regulation of T cell differentiation
  http://purl.obolibrary.org/obo/GO_0045582
• ADP metabolic process
  http://purl.obolibrary.org/obo/GO_0046031
• ATP metabolic process
  http://purl.obolibrary.org/obo/GO_0046034
• regulation of mitochondrial membrane permeability
  http://purl.obolibrary.org/obo/GO_0046902
• pore complex assembly
  http://purl.obolibrary.org/obo/GO_0046931
• protein heterodimerization activity
  http://purl.obolibrary.org/obo/GO_0046982
• positive regulation of epithelial cell proliferation
  http://purl.obolibrary.org/obo/GO_0050679
• cellular process regulating host cell cycle in response to virus
  http://purl.obolibrary.org/obo/GO_0060154
• cellular response to organic substance
  http://purl.obolibrary.org/obo/GO_0071310
• cellular response to nicotine
  http://purl.obolibrary.org/obo/GO_0071316
• apoptotic signaling pathway
  http://purl.obolibrary.org/obo/GO_0097190
• intrinsic apoptotic signaling pathway
  http://purl.obolibrary.org/obo/GO_0097193
• activation of cysteine-type endopeptidase activity
  http://purl.obolibrary.org/obo/GO_0097202
• positive regulation of type B pancreatic cell development
  http://purl.obolibrary.org/obo/GO_2000078

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map04012
• http://www.genome.jp/dbget-bin/www_bget?map04210
• http://www.genome.jp/dbget-bin/www_bget?map04370
• http://www.genome.jp/dbget-bin/www_bget?map04510
• http://www.genome.jp/dbget-bin/www_bget?map04722
• http://www.genome.jp/dbget-bin/www_bget?map04910
他14件を見る
• http://www.genome.jp/dbget-bin/www_bget?map05010
• http://www.genome.jp/dbget-bin/www_bget?map05014
• http://www.genome.jp/dbget-bin/www_bget?map05145
• http://www.genome.jp/dbget-bin/www_bget?map05152
• http://www.genome.jp/dbget-bin/www_bget?map05160
• http://www.genome.jp/dbget-bin/www_bget?map05200
• http://www.genome.jp/dbget-bin/www_bget?map05210
• http://www.genome.jp/dbget-bin/www_bget?map05212
• http://www.genome.jp/dbget-bin/www_bget?map05213
• http://www.genome.jp/dbget-bin/www_bget?map05215
• http://www.genome.jp/dbget-bin/www_bget?map05218
• http://www.genome.jp/dbget-bin/www_bget?map05220
• http://www.genome.jp/dbget-bin/www_bget?map05221
• http://www.genome.jp/dbget-bin/www_bget?map05223

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Acute myeloid leukemia
• Alzheimer's disease
• Amyotrophic lateral sclerosis (ALS)
• Apoptosis
• Chronic myeloid leukemia
• Colorectal cancer
他14件を見る
• Endometrial cancer
• ErbB signaling pathway
• Focal adhesion
• Hepatitis C
• Insulin signaling pathway
• Melanoma
• Neurotrophin signaling pathway
• Non-small cell lung cancer
• Pancreatic cancer
• Pathways in cancer
• Prostate cancer
• Toxoplasmosis
• Tuberculosis
• VEGF signaling pathway