CD03152

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD03152

CD03152

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Cdk5r1

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• cyclin-dependent kinase 5, regulatory subunit 1 (p35)

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• cyclin-dependent kinase 5 activator 1
• CDK5 activator 1
• cyclin-dependent kinase 5 regulatory subunit 1
• TPKII regulatory subunit
• cyclin-dependent kinase 5, regulatory subunit (p35) 1
• cyclin-dependent kinase 5, regulatory subunit 1 (p35)

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• p25
• CDK5P35
• D11Bwg0379e
• p35
• p35nck5a
• p23
• Cdk5r
• NCK5A

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/12569

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• cyclin-dependent kinase 5, regulatory subunit 1 (p35)
  http://metadb.riken.jp/db/mgi_rdf/MGI:101764

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_009871

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000048895

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.142275
• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.474282

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=603460

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• Sashi. Kesavapany, et.al., Identification of a novel, membrane-associated neuronal kinase, cyclin-dependent kinase 5/p35-regulated kinase., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, 23
  http://rdf.ncbi.nlm.nih.gov/pubmed/12832520
• Jiqing. Xu, et.al., Actin interaction and regulation of cyclin-dependent kinase 5/p35 complex activity., Journal of neurochemistry, 2011, 116
  http://rdf.ncbi.nlm.nih.gov/pubmed/20492361
• Vicki. Hammond, et.al., Control of cortical neuron migration and layering: cell and non cell-autonomous effects of p35., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, 24
  http://rdf.ncbi.nlm.nih.gov/pubmed/14724258
• H S. Ahuja, et.al., Association of cyclin-dependent kinase 5 and its activator p35 with apoptotic cell death., Developmental genetics, 1997, 21
  http://rdf.ncbi.nlm.nih.gov/pubmed/9438340
• Christopher L. Frank, et.al., Control of activating transcription factor 4 (ATF4) persistence by multisite phosphorylation impacts cell cycle progression and neurogenesis., The Journal of biological chemistry, 2010, 285
  http://rdf.ncbi.nlm.nih.gov/pubmed/20724472
• T. Ohshima, et.al., Molecular cloning and chromosomal mapping of the mouse gene encoding cyclin-dependent kinase 5 regulatory subunit p35., Genomics, 1996, 35
  http://rdf.ncbi.nlm.nih.gov/pubmed/8661152
• Steve D. Haenchen, et.al., Role of a cdk5-associated protein, p35, in herpes simplex virus type 1 replication in vivo., Journal of neurovirology, 2010, 16
  http://rdf.ncbi.nlm.nih.gov/pubmed/20839922
• http://rdf.ncbi.nlm.nih.gov/pubmed/20863901
• K P. Brady, et.al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis., Genome research, 1997, 7
  http://rdf.ncbi.nlm.nih.gov/pubmed/9371744
• L H. Tsai, et.al., p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5., Nature, 1994, 371
  http://rdf.ncbi.nlm.nih.gov/pubmed/8090221
• Charlene P. Poore, et.al., Cdk5-mediated phosphorylation of delta-catenin regulates its localization and GluR2-mediated synaptic activity., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, 30
  http://rdf.ncbi.nlm.nih.gov/pubmed/20573893
• T. Chae, et.al., Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality., Neuron, 1997, 18
  http://rdf.ncbi.nlm.nih.gov/pubmed/9010203

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• cadherin binding
  http://purl.obolibrary.org/obo/GO_0045296
• G-protein coupled acetylcholine receptor signaling pathway
  http://purl.obolibrary.org/obo/GO_0007213
• plasma membrane
  http://purl.obolibrary.org/obo/GO_0005886
• peptidyl-serine phosphorylation
  http://purl.obolibrary.org/obo/GO_0018105
• calcium ion binding
  http://purl.obolibrary.org/obo/GO_0005509
• axon
  http://purl.obolibrary.org/obo/GO_0030424
• protein binding
  http://purl.obolibrary.org/obo/GO_0005515
• embryo development
  http://purl.obolibrary.org/obo/GO_0009790
• membrane
  http://purl.obolibrary.org/obo/GO_0016020
• brain development
  http://purl.obolibrary.org/obo/GO_0007420
• regulation of microtubule cytoskeleton organization
  http://purl.obolibrary.org/obo/GO_0070507
• postsynaptic density
  http://purl.obolibrary.org/obo/GO_0014069
• ephrin receptor signaling pathway
  http://purl.obolibrary.org/obo/GO_0048013
• dendritic spine
  http://purl.obolibrary.org/obo/GO_0043197
• phosphorylation
  http://purl.obolibrary.org/obo/GO_0016310
• dendrite
  http://purl.obolibrary.org/obo/GO_0030425
• neuronal cell body
  http://purl.obolibrary.org/obo/GO_0043025
• cyclin-dependent protein kinase 5 holoenzyme complex
  http://purl.obolibrary.org/obo/GO_0016533
• axonal fasciculation
  http://purl.obolibrary.org/obo/GO_0007413
• ephrin receptor binding
  http://purl.obolibrary.org/obo/GO_0046875
• neuromuscular junction
  http://purl.obolibrary.org/obo/GO_0031594
• protein kinase binding
  http://purl.obolibrary.org/obo/GO_0019901
• nucleus
  http://purl.obolibrary.org/obo/GO_0005634
• ionotropic glutamate receptor signaling pathway
  http://purl.obolibrary.org/obo/GO_0035235
• cytoskeletal protein binding
  http://purl.obolibrary.org/obo/GO_0008092
• perinuclear region of cytoplasm
  http://purl.obolibrary.org/obo/GO_0048471
• regulation of dendritic spine morphogenesis
  http://purl.obolibrary.org/obo/GO_0061001
• neuron cell-cell adhesion
  http://purl.obolibrary.org/obo/GO_0007158
• protein phosphorylation
  http://purl.obolibrary.org/obo/GO_0006468
• cyclin-dependent protein kinase 5 activator activity
  http://purl.obolibrary.org/obo/GO_0016534
• positive regulation of protein phosphorylation
  http://purl.obolibrary.org/obo/GO_0001934
• growth cone
  http://purl.obolibrary.org/obo/GO_0030426
• cyclin-dependent protein serine/threonine kinase activity
  http://purl.obolibrary.org/obo/GO_0004693
• neuron differentiation
  http://purl.obolibrary.org/obo/GO_0030182
• positive regulation of neuron apoptotic process
  http://purl.obolibrary.org/obo/GO_0043525
• negative regulation of transcription, DNA-templated
  http://purl.obolibrary.org/obo/GO_0045892
• contractile fiber
  http://purl.obolibrary.org/obo/GO_0043292
• peptidyl-threonine phosphorylation
  http://purl.obolibrary.org/obo/GO_0018107
• axon guidance
  http://purl.obolibrary.org/obo/GO_0007411
• protein serine/threonine kinase activator activity
  http://purl.obolibrary.org/obo/GO_0043539
• regulation of actin cytoskeleton organization
  http://purl.obolibrary.org/obo/GO_0032956
• membrane fraction
  http://purl.obolibrary.org/obo/GO_0005624
• cell cycle
  http://purl.obolibrary.org/obo/GO_0007049
• cerebral cortex radially oriented cell migration
  http://purl.obolibrary.org/obo/GO_0021799
• cyclin-dependent protein kinase activity
  http://purl.obolibrary.org/obo/GO_0097472
• cytoplasm
  http://purl.obolibrary.org/obo/GO_0005737
• neuron migration
  http://purl.obolibrary.org/obo/GO_0001764
• kinase activity
  http://purl.obolibrary.org/obo/GO_0016301
• positive regulation of protein serine/threonine kinase activity
  http://purl.obolibrary.org/obo/GO_0071902
• neuron projection development
  http://purl.obolibrary.org/obo/GO_0031175

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map05010

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Alzheimer's disease