CD03226

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD03226

CD03226

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Pla2g4a

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• phospholipase A2, group IVA (cytosolic, calcium-dependent)

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• phospholipase A2 group IVA
• phospholipase A2, group 4
• cPLA2-alpha
• Cytosolic phospholipase A2 (CPLA2)
• phospholipase A2, group IVA (cytosolic, calcium-dependent)

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• cytosolic phospholipase A2
• Type IV PLA2
• cPLA2alpha
• Pla2g4
• cPLA2
• cytosolic PLA2

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/18783

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• phospholipase A2, group IVA (cytosolic, calcium-dependent)
  http://metadb.riken.jp/db/mgi_rdf/MGI:1195256

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_008869

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000056220

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.4186

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=600522

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• Farideh. Ghomashchi, et.al., Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms., The Journal of biological chemistry, 2010, 285
  http://rdf.ncbi.nlm.nih.gov/pubmed/20705608
• M A. Clark, et.al., Cloning of a phospholipase A2-activating protein., Proceedings of the National Academy of Sciences of the United States of America, 1991, 88
  http://rdf.ncbi.nlm.nih.gov/pubmed/2052621
• Amanda G. Linkous, et.al., Cytosolic phospholipase A2 and lysophospholipids in tumor angiogenesis., Journal of the National Cancer Institute, 2010, 102
  http://rdf.ncbi.nlm.nih.gov/pubmed/20729478
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• J D. Clark, et.al., A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)-dependent translocation domain with homology to PKC and GAP., Cell, 1991, 65
  http://rdf.ncbi.nlm.nih.gov/pubmed/1904318
• N. Uozumi, et.al., Role of cytosolic phospholipase A2 in allergic response and parturition., Nature, 1997, 390
  http://rdf.ncbi.nlm.nih.gov/pubmed/9403692
• J V. Bonventre, et.al., Reduced fertility and postischaemic brain injury in mice deficient in cytosolic phospholipase A2., Nature, 1997, 390
  http://rdf.ncbi.nlm.nih.gov/pubmed/9403693
• Longkun. Zhu, et.al., Arachidonic acid metabolism regulates Escherichia coli penetration of the blood-brain barrier., Infection and immunity, 2010, 78
  http://rdf.ncbi.nlm.nih.gov/pubmed/20696828
• P. Klivenyi, et.al., Mice deficient in group IV cytosolic phospholipase A2 are resistant to MPTP neurotoxicity., Journal of neurochemistry, 1998, 71
  http://rdf.ncbi.nlm.nih.gov/pubmed/9832165
• Nurit. Hadad, et.al., Endothelial ICAM-1 protein induction is regulated by cytosolic phospholipase A2α via both NF-κB and CREB transcription factors., Journal of immunology (Baltimore, Md. : 1950), 2011, 186
  http://rdf.ncbi.nlm.nih.gov/pubmed/21199900

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• metal ion binding
  http://purl.obolibrary.org/obo/GO_0046872
• Golgi apparatus
  http://purl.obolibrary.org/obo/GO_0005794
• lysophospholipase activity
  http://purl.obolibrary.org/obo/GO_0004622
• positive regulation of prostaglandin biosynthetic process
  http://purl.obolibrary.org/obo/GO_0031394
• calcium-dependent phospholipid binding
  http://purl.obolibrary.org/obo/GO_0005544
• icosanoid biosynthetic process
  http://purl.obolibrary.org/obo/GO_0046456
• cytoplasmic vesicle
  http://purl.obolibrary.org/obo/GO_0031410
• positive regulation of inflammatory response
  http://purl.obolibrary.org/obo/GO_0050729
• positive regulation of cell proliferation
  http://purl.obolibrary.org/obo/GO_0008284
• perinuclear region of cytoplasm
  http://purl.obolibrary.org/obo/GO_0048471
• regulation of cell proliferation
  http://purl.obolibrary.org/obo/GO_0042127
• endoplasmic reticulum
  http://purl.obolibrary.org/obo/GO_0005783
• arachidonic acid metabolic process
  http://purl.obolibrary.org/obo/GO_0019369
• zymogen granule
  http://purl.obolibrary.org/obo/GO_0042588
• phospholipase A2 activity
  http://purl.obolibrary.org/obo/GO_0004623
• decidualization
  http://purl.obolibrary.org/obo/GO_0046697
• arachidonic acid secretion
  http://purl.obolibrary.org/obo/GO_0050482
• cytoplasm
  http://purl.obolibrary.org/obo/GO_0005737
• response to calcium ion
  http://purl.obolibrary.org/obo/GO_0051592
• positive regulation of apoptotic process
  http://purl.obolibrary.org/obo/GO_0043065
• calcium-dependent phospholipase A2 activity
  http://purl.obolibrary.org/obo/GO_0047498
• positive regulation of vesicle fusion
  http://purl.obolibrary.org/obo/GO_0031340
• cytosol
  http://purl.obolibrary.org/obo/GO_0005829
• surfactant homeostasis
  http://purl.obolibrary.org/obo/GO_0043129
• hydrolase activity
  http://purl.obolibrary.org/obo/GO_0016787
• lipid catabolic process
  http://purl.obolibrary.org/obo/GO_0016042
• response to organic substance
  http://purl.obolibrary.org/obo/GO_0010033
• phospholipase activity
  http://purl.obolibrary.org/obo/GO_0004620
• nucleus
  http://purl.obolibrary.org/obo/GO_0005634
• metabolic process
  http://purl.obolibrary.org/obo/GO_0008152
• ovulation from ovarian follicle
  http://purl.obolibrary.org/obo/GO_0001542
• calcium ion binding
  http://purl.obolibrary.org/obo/GO_0005509
• membrane fraction
  http://purl.obolibrary.org/obo/GO_0005624
• cellular response to antibiotic
  http://purl.obolibrary.org/obo/GO_0071236
• phospholipid catabolic process
  http://purl.obolibrary.org/obo/GO_0009395

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map04010
• http://www.genome.jp/dbget-bin/www_bget?map04912
• http://www.genome.jp/dbget-bin/www_bget?map04666
• http://www.genome.jp/dbget-bin/www_bget?map00564
• http://www.genome.jp/dbget-bin/www_bget?map01100
• http://www.genome.jp/dbget-bin/www_bget?map00590
• http://www.genome.jp/dbget-bin/www_bget?map00592
• http://www.genome.jp/dbget-bin/www_bget?map04972
• http://www.genome.jp/dbget-bin/www_bget?map04370
• http://www.genome.jp/dbget-bin/www_bget?map04664
• http://www.genome.jp/dbget-bin/www_bget?map05145
• http://www.genome.jp/dbget-bin/www_bget?map04730
• http://www.genome.jp/dbget-bin/www_bget?map04975
• http://www.genome.jp/dbget-bin/www_bget?map00565
• http://www.genome.jp/dbget-bin/www_bget?map04270
• http://www.genome.jp/dbget-bin/www_bget?map00591
• http://www.genome.jp/dbget-bin/www_bget?map04724

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Toxoplasmosis
• Linoleic acid metabolism
• Metabolic pathways
• Glutamatergic synapse
• alpha-Linolenic acid metabolism
• Fc epsilon RI signaling pathway
• Ether lipid metabolism
• Pancreatic secretion
• GnRH signaling pathway
• MAPK signaling pathway
• Fat digestion and absorption
• Glycerophospholipid metabolism
• Fc gamma R-mediated phagocytosis
• VEGF signaling pathway
• Arachidonic acid metabolism
• Long-term depression
• Vascular smooth muscle contraction