CD03228

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD03228

CD03228

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Doc2b

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• double C2, beta

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• double C2 protein beta
• double C2, beta
• doc2-beta
• double C2-like domain-containing protein beta

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/13447

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• double C2, beta
  http://metadb.riken.jp/db/mgi_rdf/MGI:1100497

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_007873

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000020848

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.5137

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=604568

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• T. Kojima, et.al., Calcium-dependent phospholipid binding to the C2A domain of a ubiquitous form of double C2 protein (Doc2 beta)., Journal of biochemistry, 1996, 120
  http://rdf.ncbi.nlm.nih.gov/pubmed/8902635
• Bin. Chen, et.al., Fezl regulates the differentiation and axon targeting of layer 5 subcortical projection neurons in cerebral cortex., Proceedings of the National Academy of Sciences of the United States of America, 2005, 102
  http://rdf.ncbi.nlm.nih.gov/pubmed/16284245
• Naofumi. Fukuda, et.al., DOC2B: a novel syntaxin-4 binding protein mediating insulin-regulated GLUT4 vesicle fusion in adipocytes., Diabetes, 2009, 58
  http://rdf.ncbi.nlm.nih.gov/pubmed/19033398
• J. Bouwman, et.al., Quantification of synapse formation and maintenance in vivo in the absence of synaptic release., Neuroscience, 2004, 126
  http://rdf.ncbi.nlm.nih.gov/pubmed/15145078
• Ruud F G. Toonen, et.al., Munc18-1 stabilizes syntaxin 1, but is not essential for syntaxin 1 targeting and SNARE complex formation., Journal of neurochemistry, 2005, 93
  http://rdf.ncbi.nlm.nih.gov/pubmed/15935055
• Mutsuko. Miyazaki, et.al., DOC2b is a SNARE regulator of glucose-stimulated delayed insulin secretion., Biochemical and biophysical research communications, 2009, 384
  http://rdf.ncbi.nlm.nih.gov/pubmed/19410553
• Alexander J A. Groffen, et.al., DOC2A and DOC2B are sensors for neuronal activity with unique calcium-dependent and kinetic properties., Journal of neurochemistry, 2006, 97
  http://rdf.ncbi.nlm.nih.gov/pubmed/16515538
• Reut. Friedrich, et.al., DOC2B acts as a calcium switch and enhances vesicle fusion., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, 28
  http://rdf.ncbi.nlm.nih.gov/pubmed/18596155
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• G. Sakaguchi, et.al., Molecular cloning of an isoform of Doc2 having two C2-like domains., Biochemical and biophysical research communications, 1995, 217
  http://rdf.ncbi.nlm.nih.gov/pubmed/8554557
• Alexander J. Groffen, et.al., Doc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter release., Science (New York, N.Y.), 2010, 327
  http://rdf.ncbi.nlm.nih.gov/pubmed/20150444
• N. Korteweg, et.al., Different spatiotemporal expression of DOC2 genes in the developing rat brain argues for an additional, nonsynaptic role of DOC2B in early development., The European journal of neuroscience, 2000, 12
  http://rdf.ncbi.nlm.nih.gov/pubmed/10651871

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• protein localization
  http://purl.obolibrary.org/obo/GO_0008104
• membrane
  http://purl.obolibrary.org/obo/GO_0016020
• positive regulation of calcium ion-dependent exocytosis
  http://purl.obolibrary.org/obo/GO_0045956
• syntaxin binding
  http://purl.obolibrary.org/obo/GO_0019905
• SNARE complex
  http://purl.obolibrary.org/obo/GO_0031201
• synaptic vesicle
  http://purl.obolibrary.org/obo/GO_0008021
• cytoplasm
  http://purl.obolibrary.org/obo/GO_0005737
• transport
  http://purl.obolibrary.org/obo/GO_0006810
• plasma membrane
  http://purl.obolibrary.org/obo/GO_0005886
• cell
  http://purl.obolibrary.org/obo/GO_0005623
• positive regulation of vesicle fusion
  http://purl.obolibrary.org/obo/GO_0031340
• calcium-dependent phospholipid binding
  http://purl.obolibrary.org/obo/GO_0005544
• transporter activity
  http://purl.obolibrary.org/obo/GO_0005215
• positive regulation of insulin secretion
  http://purl.obolibrary.org/obo/GO_0032024
• protein binding
  http://purl.obolibrary.org/obo/GO_0005515

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName