CD03264

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD03264

CD03264

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Otx2

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• orthodenticle homolog 2 (Drosophila)

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• orthodenticle homolog 2 (Drosophila)
• homeobox protein OTX2

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• E130306E05Rik

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/18424

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• orthodenticle homeobox 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:97451

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_144841

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000021848

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.134516

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=600037

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• Seiichi. Koike, et.al., Autotaxin is required for the cranial neural tube closure and establishment of the midbrain-hindbrain boundary during mouse development., Developmental dynamics : an official publication of the American Association of Anatomists, 2011, 240
  http://rdf.ncbi.nlm.nih.gov/pubmed/21246658
• Michela. Di Salvio, et.al., Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP., Nature neuroscience, 2010, 13
  http://rdf.ncbi.nlm.nih.gov/pubmed/21057506
• S. Cereghini, et.al., Expression patterns of vHNF1 and HNF1 homeoproteins in early postimplantation embryos suggest distinct and sequential developmental roles., Development (Cambridge, England), 1992, 116
  http://rdf.ncbi.nlm.nih.gov/pubmed/1363228
• I. Matsuo, et.al., Mouse Otx2 functions in the formation and patterning of rostral head., Genes & development, 1995, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/7590242
• Jiang. Fu, et.al., Gpr177/mouse Wntless is essential for Wnt-mediated craniofacial and brain development., Developmental dynamics : an official publication of the American Association of Anatomists, 2011, 240
  http://rdf.ncbi.nlm.nih.gov/pubmed/21246653
• A. Simeone, et.al., Nested expression domains of four homeobox genes in developing rostral brain., Nature, 1992, 358
  http://rdf.ncbi.nlm.nih.gov/pubmed/1353865
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• S L. Ang, et.al., Positive and negative signals from mesoderm regulate the expression of mouse Otx2 in ectoderm explants., Development (Cambridge, England), 1994, 120
  http://rdf.ncbi.nlm.nih.gov/pubmed/7607086
• D. Acampora, et.al., Forebrain and midbrain regions are deleted in Otx2-/- mutants due to a defective anterior neuroectoderm specification during gastrulation., Development (Cambridge, England), 1995, 121
  http://rdf.ncbi.nlm.nih.gov/pubmed/7588062
• Cuiling. Li, et.al., Anterior visceral endoderm SMAD4 signaling specifies anterior embryonic patterning and head induction in mice., International journal of biological sciences, 2010, 6
  http://rdf.ncbi.nlm.nih.gov/pubmed/20941375

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• endoderm development
  http://purl.obolibrary.org/obo/GO_0007492
• cell fate specification
  http://purl.obolibrary.org/obo/GO_0001708
• regulation of transcription from RNA polymerase II promoter
  http://purl.obolibrary.org/obo/GO_0006357
• DNA binding
  http://purl.obolibrary.org/obo/GO_0003677
• neuron fate commitment
  http://purl.obolibrary.org/obo/GO_0048663
• forebrain development
  http://purl.obolibrary.org/obo/GO_0030900
• macromolecular complex assembly
  http://purl.obolibrary.org/obo/GO_0065003
• positive regulation of transcription from RNA polymerase II promoter
  http://purl.obolibrary.org/obo/GO_0045944
• cell fate commitment
  http://purl.obolibrary.org/obo/GO_0045165
• growth cone
  http://purl.obolibrary.org/obo/GO_0030426
• eye photoreceptor cell fate commitment
  http://purl.obolibrary.org/obo/GO_0042706
• cell differentiation
  http://purl.obolibrary.org/obo/GO_0030154
• protein heterodimerization activity
  http://purl.obolibrary.org/obo/GO_0046982
• axon guidance
  http://purl.obolibrary.org/obo/GO_0007411
• dorsal/ventral pattern formation
  http://purl.obolibrary.org/obo/GO_0009953
• central nervous system development
  http://purl.obolibrary.org/obo/GO_0007417
• macromolecular complex
  http://purl.obolibrary.org/obo/GO_0032991
• RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
  http://purl.obolibrary.org/obo/GO_0001077
• somite rostral/caudal axis specification
  http://purl.obolibrary.org/obo/GO_0032525
• nucleus
  http://purl.obolibrary.org/obo/GO_0005634
• inner ear morphogenesis
  http://purl.obolibrary.org/obo/GO_0042472
• anatomical structure development
  http://purl.obolibrary.org/obo/GO_0048856
• cytoplasm
  http://purl.obolibrary.org/obo/GO_0005737
• protein binding
  http://purl.obolibrary.org/obo/GO_0005515
• midbrain development
  http://purl.obolibrary.org/obo/GO_0030901
• neuron differentiation
  http://purl.obolibrary.org/obo/GO_0030182
• anterior/posterior pattern specification
  http://purl.obolibrary.org/obo/GO_0009952
• primitive streak formation
  http://purl.obolibrary.org/obo/GO_0090009

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName