CD03269

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD03269

CD03269

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Ptch1

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• patched homolog 1

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• mesenchymal dysplasia
• patched homolog 1
• Ptch1 protein +12b
• protein patched homolog 1

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• Ptch
• Ptc1
• Ptc
• Patched 1
• mes
• A230106A15Rik

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/19206

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• patched 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:105373

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_008957

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000021466

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.228798

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=601309

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• D J. Epstein, et.al., Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway., Development (Cambridge, England), 1996, 122
  http://rdf.ncbi.nlm.nih.gov/pubmed/8787761
• Jian. Qin, et.al., Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components., Proceedings of the National Academy of Sciences of the United States of America, 2011, 108
  http://rdf.ncbi.nlm.nih.gov/pubmed/21209331
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• L V. Goodrich, et.al., Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog., Genes & development, 1996, 10
  http://rdf.ncbi.nlm.nih.gov/pubmed/8595881
• Jinny J. Kim, et.al., Suppressor of fused controls mid-hindbrain patterning and cerebellar morphogenesis via GLI3 repressor., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, 31
  http://rdf.ncbi.nlm.nih.gov/pubmed/21289193
• Paul. Gibson, et.al., Subtypes of medulloblastoma have distinct developmental origins., Nature, 2010, 468
  http://rdf.ncbi.nlm.nih.gov/pubmed/21150899
• Gerrit J P. Dijkgraaf, et.al., Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance., Cancer research, 2011, 71
  http://rdf.ncbi.nlm.nih.gov/pubmed/21123452
• H. Hahn, et.al., Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome., Cell, 1996, 85
  http://rdf.ncbi.nlm.nih.gov/pubmed/8681379
• H. Hahn, et.al., A mammalian patched homolog is expressed in target tissues of sonic hedgehog and maps to a region associated with developmental abnormalities., The Journal of biological chemistry, 1996, 271
  http://rdf.ncbi.nlm.nih.gov/pubmed/8647801
• http://rdf.ncbi.nlm.nih.gov/pubmed/8830098

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• midbody
  http://purl.obolibrary.org/obo/GO_0030496
• negative regulation of osteoblast differentiation
  http://purl.obolibrary.org/obo/GO_0045668
• regulation of mitotic cell cycle
  http://purl.obolibrary.org/obo/GO_0007346
• brain development
  http://purl.obolibrary.org/obo/GO_0007420
• cell differentiation involved in kidney development
  http://purl.obolibrary.org/obo/GO_0061005
• membrane
  http://purl.obolibrary.org/obo/GO_0016020
• mammary gland duct morphogenesis
  http://purl.obolibrary.org/obo/GO_0060603
• integral component of membrane
  http://purl.obolibrary.org/obo/GO_0016021
• embryonic limb morphogenesis
  http://purl.obolibrary.org/obo/GO_0030326
• regulation of growth
  http://purl.obolibrary.org/obo/GO_0040008
• negative regulation of transcription from RNA polymerase II promoter
  http://purl.obolibrary.org/obo/GO_0000122
• dendritic growth cone
  http://purl.obolibrary.org/obo/GO_0044294
• cargo receptor activity
  http://purl.obolibrary.org/obo/GO_0038024
• response to chlorate
  http://purl.obolibrary.org/obo/GO_0010157
• intracellular membrane-bounded organelle
  http://purl.obolibrary.org/obo/GO_0043231
• hindlimb morphogenesis
  http://purl.obolibrary.org/obo/GO_0035137
• negative regulation of epithelial cell proliferation
  http://purl.obolibrary.org/obo/GO_0050680
• axonal growth cone
  http://purl.obolibrary.org/obo/GO_0044295
• glucose homeostasis
  http://purl.obolibrary.org/obo/GO_0042593
• pattern specification process
  http://purl.obolibrary.org/obo/GO_0007389
• neural tube formation
  http://purl.obolibrary.org/obo/GO_0001841
• epidermis development
  http://purl.obolibrary.org/obo/GO_0008544
• dorsal/ventral pattern formation
  http://purl.obolibrary.org/obo/GO_0009953
• smoothened binding
  http://purl.obolibrary.org/obo/GO_0005119
• postsynaptic density
  http://purl.obolibrary.org/obo/GO_0014069
• signal transduction
  http://purl.obolibrary.org/obo/GO_0007165
• negative regulation of cell proliferation
  http://purl.obolibrary.org/obo/GO_0008285
• cell proliferation involved in metanephros development
  http://purl.obolibrary.org/obo/GO_0072203
• perinuclear region of cytoplasm
  http://purl.obolibrary.org/obo/GO_0048471
• caveola
  http://purl.obolibrary.org/obo/GO_0005901
• regulation of protein localization
  http://purl.obolibrary.org/obo/GO_0032880
• zinc ion binding
  http://purl.obolibrary.org/obo/GO_0008270
• positive regulation of cholesterol efflux
  http://purl.obolibrary.org/obo/GO_0010875
• negative regulation of smoothened signaling pathway
  http://purl.obolibrary.org/obo/GO_0045879
• dorsal/ventral neural tube patterning
  http://purl.obolibrary.org/obo/GO_0021904
• hedgehog receptor activity
  http://purl.obolibrary.org/obo/GO_0008158
• regulation of smoothened signaling pathway
  http://purl.obolibrary.org/obo/GO_0008589
• somite development
  http://purl.obolibrary.org/obo/GO_0061053
• mammary gland epithelial cell differentiation
  http://purl.obolibrary.org/obo/GO_0060644
• negative regulation of multicellular organism growth
  http://purl.obolibrary.org/obo/GO_0040015
• smoothened signaling pathway
  http://purl.obolibrary.org/obo/GO_0007224
• keratinocyte proliferation
  http://purl.obolibrary.org/obo/GO_0043616
• pharyngeal system development
  http://purl.obolibrary.org/obo/GO_0060037
• heart morphogenesis
  http://purl.obolibrary.org/obo/GO_0003007
• neural plate axis specification
  http://purl.obolibrary.org/obo/GO_0021997
• neural tube closure
  http://purl.obolibrary.org/obo/GO_0001843
• negative regulation of sequence-specific DNA binding transcription factor activity
  http://purl.obolibrary.org/obo/GO_0043433
• mammary gland development
  http://purl.obolibrary.org/obo/GO_0030879
• protein processing
  http://purl.obolibrary.org/obo/GO_0016485
• cyclin binding
  http://purl.obolibrary.org/obo/GO_0030332
• neural tube patterning
  http://purl.obolibrary.org/obo/GO_0021532
• regulation of cell proliferation
  http://purl.obolibrary.org/obo/GO_0042127
• branching involved in ureteric bud morphogenesis
  http://purl.obolibrary.org/obo/GO_0001658
• cholesterol binding
  http://purl.obolibrary.org/obo/GO_0015485
• protein binding
  http://purl.obolibrary.org/obo/GO_0005515
• hedgehog family protein binding
  http://purl.obolibrary.org/obo/GO_0097108
• signaling receptor activity
  http://purl.obolibrary.org/obo/GO_0038023
• plasma membrane
  http://purl.obolibrary.org/obo/GO_0005886
• heparin binding
  http://purl.obolibrary.org/obo/GO_0008201
• limb morphogenesis
  http://purl.obolibrary.org/obo/GO_0035108
• integral component of plasma membrane
  http://purl.obolibrary.org/obo/GO_0005887
• patched binding
  http://purl.obolibrary.org/obo/GO_0005113
• extracellular region
  http://purl.obolibrary.org/obo/GO_0005576
• cellular response to cholesterol
  http://purl.obolibrary.org/obo/GO_0071397
• protein localization to plasma membrane
  http://purl.obolibrary.org/obo/GO_0072659

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map05217
• http://www.genome.jp/dbget-bin/www_bget?map05200
• http://www.genome.jp/dbget-bin/www_bget?map04340

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Hedgehog signaling pathway
• Basal cell carcinoma
• Pathways in cancer