CD03287

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD03287

CD03287

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Psen2

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• presenilin 2

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• presenilin-2
• presenilin 2

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• PS2
• Ad4h
• ALG-3
• Alg3
• Psnl2
• PS-2
• STM2

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/19165

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• presenilin 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:109284

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_001128605
• https://www.ncbi.nlm.nih.gov/nuccore/NM_011183

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000010609

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.330850

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=600759

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• Young Jung. Lee, et.al., 4-O-Methylhonokiol attenuates memory impairment in presenilin 2 mutant mice through reduction of oxidative damage and inactivation of astrocytes and the ERK pathway., Free radical biology & medicine, 2011, 50
  http://rdf.ncbi.nlm.nih.gov/pubmed/20974250
• Jenny. Frånberg, et.al., Minor contribution of presenilin 2 for γ-secretase activity in mouse embryonic fibroblasts and adult mouse brain., Biochemical and biophysical research communications, 2011, 404
  http://rdf.ncbi.nlm.nih.gov/pubmed/21146496
• Suman. Jayadev, et.al., Presenilin 2 is the predominant γ-secretase in microglia and modulates cytokine release., PloS one, 2010, 5
  http://rdf.ncbi.nlm.nih.gov/pubmed/21206757
• M A. Pericak-Vance, et.al., Genetic susceptibility to Alzheimer disease., Trends in genetics : TIG, 1995, 11
  http://rdf.ncbi.nlm.nih.gov/pubmed/8533168
• M K. Lee, et.al., Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues., The Journal of neuroscience : the official journal of the Society for Neuroscience, 1996, 16
  http://rdf.ncbi.nlm.nih.gov/pubmed/8922407
• G. Thinakaran, et.al., Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo., Neuron, 1996, 17
  http://rdf.ncbi.nlm.nih.gov/pubmed/8755489
• P. Vito, et.al., Requirement of the familial Alzheimer's disease gene PS2 for apoptosis. Opposing effect of ALG-3., The Journal of biological chemistry, 1996, 271
  http://rdf.ncbi.nlm.nih.gov/pubmed/8940094
• P. Vito, et.al., Interfering with apoptosis: Ca(2+)-binding protein ALG-2 and Alzheimer's disease gene ALG-3., Science (New York, N.Y.), 1996, 271
  http://rdf.ncbi.nlm.nih.gov/pubmed/8560270
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• Enrico. Zampese, et.al., Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk., Proceedings of the National Academy of Sciences of the United States of America, 2011, 108
  http://rdf.ncbi.nlm.nih.gov/pubmed/21285369

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• somitogenesis
  http://purl.obolibrary.org/obo/GO_0001756
• Z disc
  http://purl.obolibrary.org/obo/GO_0030018
• dorsal/ventral neural tube patterning
  http://purl.obolibrary.org/obo/GO_0021904
• endoplasmic reticulum
  http://purl.obolibrary.org/obo/GO_0005783
• cell fate specification
  http://purl.obolibrary.org/obo/GO_0001708
• protein processing
  http://purl.obolibrary.org/obo/GO_0016485
• apical plasma membrane
  http://purl.obolibrary.org/obo/GO_0016324
• growth cone
  http://purl.obolibrary.org/obo/GO_0030426
• ciliary rootlet
  http://purl.obolibrary.org/obo/GO_0035253
• cell surface
  http://purl.obolibrary.org/obo/GO_0009986
• positive regulation of proteasomal ubiquitin-dependent protein catabolic process
  http://purl.obolibrary.org/obo/GO_0032436
• memory
  http://purl.obolibrary.org/obo/GO_0007613
• positive regulation of apoptotic process
  http://purl.obolibrary.org/obo/GO_0043065
• regulation of synaptic plasticity
  http://purl.obolibrary.org/obo/GO_0048167
• forebrain development
  http://purl.obolibrary.org/obo/GO_0030900
• peptidase activity
  http://purl.obolibrary.org/obo/GO_0008233
• embryo development
  http://purl.obolibrary.org/obo/GO_0009790
• Golgi apparatus
  http://purl.obolibrary.org/obo/GO_0005794
• negative regulation of epidermal growth factor-activated receptor activity
  http://purl.obolibrary.org/obo/GO_0007175
• Notch receptor processing
  http://purl.obolibrary.org/obo/GO_0007220
• membrane protein ectodomain proteolysis
  http://purl.obolibrary.org/obo/GO_0006509
• intracellular
  http://purl.obolibrary.org/obo/GO_0005622
• T cell receptor signaling pathway
  http://purl.obolibrary.org/obo/GO_0050852
• cardiac muscle contraction
  http://purl.obolibrary.org/obo/GO_0060048
• intracellular signal transduction
  http://purl.obolibrary.org/obo/GO_0035556
• negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
  http://purl.obolibrary.org/obo/GO_2000059
• myeloid leukocyte differentiation
  http://purl.obolibrary.org/obo/GO_0002573
• dendritic shaft
  http://purl.obolibrary.org/obo/GO_0043198
• protein maturation
  http://purl.obolibrary.org/obo/GO_0051604
• locomotion
  http://purl.obolibrary.org/obo/GO_0040011
• anagen
  http://purl.obolibrary.org/obo/GO_0042640
• membrane
  http://purl.obolibrary.org/obo/GO_0016020
• integral component of membrane
  http://purl.obolibrary.org/obo/GO_0016021
• lysosomal membrane
  http://purl.obolibrary.org/obo/GO_0005765
• cellular protein metabolic process
  http://purl.obolibrary.org/obo/GO_0044267
• mitochondrial inner membrane
  http://purl.obolibrary.org/obo/GO_0005743
• cell cortex
  http://purl.obolibrary.org/obo/GO_0005938
• learning or memory
  http://purl.obolibrary.org/obo/GO_0007611
• proteolysis
  http://purl.obolibrary.org/obo/GO_0006508
• endopeptidase activity
  http://purl.obolibrary.org/obo/GO_0004175
• Notch signaling pathway
  http://purl.obolibrary.org/obo/GO_0007219
• brain morphogenesis
  http://purl.obolibrary.org/obo/GO_0048854
• negative regulation of transcription from RNA polymerase II promoter
  http://purl.obolibrary.org/obo/GO_0000122
• cytosol
  http://purl.obolibrary.org/obo/GO_0005829
• aspartic-type endopeptidase activity
  http://purl.obolibrary.org/obo/GO_0004190
• positive regulation of receptor recycling
  http://purl.obolibrary.org/obo/GO_0001921
• centrosome
  http://purl.obolibrary.org/obo/GO_0005813
• kinetochore
  http://purl.obolibrary.org/obo/GO_0000776
• skin morphogenesis
  http://purl.obolibrary.org/obo/GO_0043589
• neuromuscular junction
  http://purl.obolibrary.org/obo/GO_0031594
• thymus development
  http://purl.obolibrary.org/obo/GO_0048538
• positive regulation of coagulation
  http://purl.obolibrary.org/obo/GO_0050820
• beta-amyloid metabolic process
  http://purl.obolibrary.org/obo/GO_0050435
• nucleus
  http://purl.obolibrary.org/obo/GO_0005634
• neuronal cell body
  http://purl.obolibrary.org/obo/GO_0043025
• embryonic limb morphogenesis
  http://purl.obolibrary.org/obo/GO_0030326
• hematopoietic progenitor cell differentiation
  http://purl.obolibrary.org/obo/GO_0002244
• perinuclear region of cytoplasm
  http://purl.obolibrary.org/obo/GO_0048471
• negative regulation of protein phosphorylation
  http://purl.obolibrary.org/obo/GO_0001933
• hair follicle development
  http://purl.obolibrary.org/obo/GO_0001942
• macromolecular complex
  http://purl.obolibrary.org/obo/GO_0032991
• membrane raft
  http://purl.obolibrary.org/obo/GO_0045121
• membrane fraction
  http://purl.obolibrary.org/obo/GO_0005624
• axon
  http://purl.obolibrary.org/obo/GO_0030424
• nuclear inner membrane
  http://purl.obolibrary.org/obo/GO_0005637
• protein transport
  http://purl.obolibrary.org/obo/GO_0015031
• hydrolase activity
  http://purl.obolibrary.org/obo/GO_0016787
• calcium ion transport
  http://purl.obolibrary.org/obo/GO_0006816
• protein binding
  http://purl.obolibrary.org/obo/GO_0005515
• amyloid precursor protein catabolic process
  http://purl.obolibrary.org/obo/GO_0042987
• positive regulation of catalytic activity
  http://purl.obolibrary.org/obo/GO_0043085
• lung alveolus development
  http://purl.obolibrary.org/obo/GO_0048286
• regulation of epidermal growth factor-activated receptor activity
  http://purl.obolibrary.org/obo/GO_0007176
• integral component of plasma membrane
  http://purl.obolibrary.org/obo/GO_0005887
• negative regulation of apoptotic process
  http://purl.obolibrary.org/obo/GO_0043066
• T cell activation involved in immune response
  http://purl.obolibrary.org/obo/GO_0002286
• apoptotic process
  http://purl.obolibrary.org/obo/GO_0006915

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map04330
• http://www.genome.jp/dbget-bin/www_bget?map04722
• http://www.genome.jp/dbget-bin/www_bget?map05010

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Alzheimer's disease
• Notch signaling pathway
• Neurotrophin signaling pathway