CD03316

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD03316

CD03316

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Shank3

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• SH3/ankyrin domain gene 3

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• proSAP2
• SPANK-2
• SH3/ankyrin domain gene 3
• proline-rich synapse-associated protein 2
• SH3 and multiple ankyrin repeat domains protein 3

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• PROSAP2
• SPANK-2
• Shank3b
• AI841104
• KIAA1650
• PSAP2

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/58234

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• SH3/ankyrin domain gene 3
  http://metadb.riken.jp/db/mgi_rdf/MGI:1930016

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_021423

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000022623

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.146855

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=606230

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• Annalisa. Bolis, et.al., Differential distribution of Rac1 and Rac3 GTPases in the developing mouse brain: implications for a role of Rac3 in Purkinje cell differentiation., The European journal of neuroscience, 2003, 18
  http://rdf.ncbi.nlm.nih.gov/pubmed/14622142
• Gautier. Roussignol, et.al., Shank expression is sufficient to induce functional dendritic spine synapses in aspiny neurons., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, 25
  http://rdf.ncbi.nlm.nih.gov/pubmed/15814786
• Noriko. Okazaki, et.al., Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries., DNA research : an international journal for rapid publication of reports on genes and genomes, 2004, 11
  http://rdf.ncbi.nlm.nih.gov/pubmed/15368895
• M. Raab, et.al., Proline-rich synapse-associated protein-1 and 2 (ProSAP1/Shank2 and ProSAP2/Shank3)-scaffolding proteins are also present in postsynaptic specializations of the peripheral nervous system., Neuroscience, 2010, 171
  http://rdf.ncbi.nlm.nih.gov/pubmed/20800661
• Gunnar. Schuetz, et.al., The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells., The Journal of cell biology, 2004, 167
  http://rdf.ncbi.nlm.nih.gov/pubmed/15569713
• Patricia A. Olson, et.al., G-protein-coupled receptor modulation of striatal CaV1.3 L-type Ca2+ channels is dependent on a Shank-binding domain., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, 25
  http://rdf.ncbi.nlm.nih.gov/pubmed/15689540
• Shigeo. Uchino, et.al., Direct interaction of post-synaptic density-95/Dlg/ZO-1 domain-containing synaptic molecule Shank3 with GluR1 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor., Journal of neurochemistry, 2006, 97
  http://rdf.ncbi.nlm.nih.gov/pubmed/16606358
• Corinna. Sawallisch, et.al., The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity., The Journal of biological chemistry, 2009, 284
  http://rdf.ncbi.nlm.nih.gov/pubmed/19208628
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• Susan. Magdaleno, et.al., BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system., PLoS biology, 2006, 4
  http://rdf.ncbi.nlm.nih.gov/pubmed/16602821

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• positive regulation of long-term neuronal synaptic plasticity
  http://purl.obolibrary.org/obo/GO_0048170
• GKAP/Homer scaffold activity
  http://purl.obolibrary.org/obo/GO_0030160
• zinc ion binding
  http://purl.obolibrary.org/obo/GO_0008270
• regulation of behavioral fear response
  http://purl.obolibrary.org/obo/GO_2000822
• neuron spine
  http://purl.obolibrary.org/obo/GO_0044309
• regulation of grooming behavior
  http://purl.obolibrary.org/obo/GO_2000821
• synapse
  http://purl.obolibrary.org/obo/GO_0045202
• ionotropic glutamate receptor binding
  http://purl.obolibrary.org/obo/GO_0035255
• positive regulation of synapse structural plasticity
  http://purl.obolibrary.org/obo/GO_0051835
• postsynaptic density
  http://purl.obolibrary.org/obo/GO_0014069
• scaffold protein binding
  http://purl.obolibrary.org/obo/GO_0097110
• protein binding
  http://purl.obolibrary.org/obo/GO_0005515
• protein self-association
  http://purl.obolibrary.org/obo/GO_0043621
• excitatory synapse
  http://purl.obolibrary.org/obo/GO_0060076
• MAPK cascade
  http://purl.obolibrary.org/obo/GO_0000165
• cell junction
  http://purl.obolibrary.org/obo/GO_0030054
• embryonic epithelial tube formation
  http://purl.obolibrary.org/obo/GO_0001838
• positive regulation of synaptic transmission, glutamatergic
  http://purl.obolibrary.org/obo/GO_0051968
• positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
  http://purl.obolibrary.org/obo/GO_2000969
• protein oligomerization
  http://purl.obolibrary.org/obo/GO_0051259
• cytoplasm
  http://purl.obolibrary.org/obo/GO_0005737
• membrane
  http://purl.obolibrary.org/obo/GO_0016020
• vocalization behavior
  http://purl.obolibrary.org/obo/GO_0071625
• brain morphogenesis
  http://purl.obolibrary.org/obo/GO_0048854
• locomotory exploration behavior
  http://purl.obolibrary.org/obo/GO_0035641
• striatal medium spiny neuron differentiation
  http://purl.obolibrary.org/obo/GO_0021773
• social behavior
  http://purl.obolibrary.org/obo/GO_0035176
• synapse assembly
  http://purl.obolibrary.org/obo/GO_0007416
• dendritic spine morphogenesis
  http://purl.obolibrary.org/obo/GO_0060997
• plasma membrane
  http://purl.obolibrary.org/obo/GO_0005886
• SH3 domain binding
  http://purl.obolibrary.org/obo/GO_0017124
• negative regulation of cell volume
  http://purl.obolibrary.org/obo/GO_0045794
• intracellular
  http://purl.obolibrary.org/obo/GO_0005622
• postsynaptic density assembly
  http://purl.obolibrary.org/obo/GO_0097107
• postsynaptic membrane
  http://purl.obolibrary.org/obo/GO_0045211
• protein C-terminus binding
  http://purl.obolibrary.org/obo/GO_0008022

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map04724

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Glutamatergic synapse