CD04251

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD04251

CD04251

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Pycard

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• PYD and CARD domain containing

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• PYD and CARD domain containing
• PYD and CARD domain-containing protein
• apoptosis-associated speck-like protein containing a CARD

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• Asc
• TNS1
• CARD5
• masc
• 9130417A21Rik
• TMS-1

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/66824

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• PYD and CARD domain containing
  http://metadb.riken.jp/db/mgi_rdf/MGI:1931465

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_023258

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000030793

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.24163

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=606838

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• John C. Reed, et.al., Comparative analysis of apoptosis and inflammation genes of mice and humans., Genome research, 2003, 13
  http://rdf.ncbi.nlm.nih.gov/pubmed/12819136
• Rongbin. Zhou, et.al., A role for mitochondria in NLRP3 inflammasome activation., Nature, 2011, 469
  http://rdf.ncbi.nlm.nih.gov/pubmed/21124315
• Masatatsu. Yamamoto, et.al., ASC is essential for LPS-induced activation of procaspase-1 independently of TLR-associated signal adaptor molecules., Genes to cells : devoted to molecular & cellular mechanisms, 2004, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/15507117
• Ali H. Ellebedy, et.al., Inflammasome-independent role of the apoptosis-associated speck-like protein containing CARD (ASC) in the adjuvant effect of MF59., Proceedings of the National Academy of Sciences of the United States of America, 2011, 108
  http://rdf.ncbi.nlm.nih.gov/pubmed/21270336
• Greta. Guarda, et.al., Type I interferon inhibits interleukin-1 production and inflammasome activation., Immunity, 2011, 34
  http://rdf.ncbi.nlm.nih.gov/pubmed/21349431
• F. Martinon, et.al., The pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation., Current biology : CB, 2001, 11
  http://rdf.ncbi.nlm.nih.gov/pubmed/11250163
• Ramanjaneyulu. Allam, et.al., Cutting edge: cyclic polypeptide and aminoglycoside antibiotics trigger IL-1β secretion by activating the NLRP3 inflammasome., Journal of immunology (Baltimore, Md. : 1950), 2011, 186
  http://rdf.ncbi.nlm.nih.gov/pubmed/21278344
• J. Masumoto, et.al., Murine ortholog of ASC, a CARD-containing protein, self-associates and exhibits restricted distribution in developing mouse embryos., Experimental cell research, 2001, 262
  http://rdf.ncbi.nlm.nih.gov/pubmed/11139337
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• Sanjeev. Mariathasan, et.al., Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf., Nature, 2004, 430
  http://rdf.ncbi.nlm.nih.gov/pubmed/15190255

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• ion channel binding
  http://purl.obolibrary.org/obo/GO_0044325
• interleukin-1 beta production
  http://purl.obolibrary.org/obo/GO_0032611
• peptidase activator activity involved in apoptotic process
  http://purl.obolibrary.org/obo/GO_0016505
• intracellular
  http://purl.obolibrary.org/obo/GO_0005622
• activation of cysteine-type endopeptidase activity involved in apoptotic process
  http://purl.obolibrary.org/obo/GO_0006919
• positive regulation of NF-kappaB transcription factor activity
  http://purl.obolibrary.org/obo/GO_0051092
• extracellular region
  http://purl.obolibrary.org/obo/GO_0005576
• macromolecular complex
  http://purl.obolibrary.org/obo/GO_0032991
• apoptotic process
  http://purl.obolibrary.org/obo/GO_0006915
• neuronal cell body
  http://purl.obolibrary.org/obo/GO_0043025
• tumor necrosis factor-mediated signaling pathway
  http://purl.obolibrary.org/obo/GO_0033209
• protein binding
  http://purl.obolibrary.org/obo/GO_0005515
• cytosol
  http://purl.obolibrary.org/obo/GO_0005829
• inflammatory response
  http://purl.obolibrary.org/obo/GO_0006954
• positive regulation of interleukin-1 beta secretion
  http://purl.obolibrary.org/obo/GO_0050718
• protease binding
  http://purl.obolibrary.org/obo/GO_0002020
• cytoplasm
  http://purl.obolibrary.org/obo/GO_0005737
• positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
  http://purl.obolibrary.org/obo/GO_0043280
• regulation of apoptotic process
  http://purl.obolibrary.org/obo/GO_0042981
• protein homodimerization activity
  http://purl.obolibrary.org/obo/GO_0042803
• Pyrin domain binding
  http://purl.obolibrary.org/obo/GO_0032090
• activation of cysteine-type endopeptidase activity
  http://purl.obolibrary.org/obo/GO_0097202
• regulation of cysteine-type endopeptidase activity involved in apoptotic process
  http://purl.obolibrary.org/obo/GO_0043281
• cytoplasmic part
  http://purl.obolibrary.org/obo/GO_0044444

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map05132
• http://www.genome.jp/dbget-bin/www_bget?map05164
• http://www.genome.jp/dbget-bin/www_bget?map05134
• http://www.genome.jp/dbget-bin/www_bget?map04621
• http://www.genome.jp/dbget-bin/www_bget?map04623
• http://www.genome.jp/dbget-bin/www_bget?map05133

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Cytosolic DNA-sensing pathway
• Influenza A
• Salmonella infection
• Legionellosis
• NOD-like receptor signaling pathway
• Pertussis