CD04514

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD04514

CD04514

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Pak3

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• p21 protein (Cdc42/Rac)-activated kinase 3

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• beta-PAK
• CDC42/RAC effector kinase PAK-B
• p21-activated kinase 3
• serine/threonine-protein kinase PAK 3
• p21 protein (Cdc42/Rac)-activated kinase 3

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• Pak65beta
• Pak65alpha
• PAK-3
• Stk4

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/18481

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• p21 protein (Cdc42/Rac)-activated kinase 3
  http://metadb.riken.jp/db/mgi_rdf/MGI:1339656

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_001195047
• https://www.ncbi.nlm.nih.gov/nuccore/NM_001195048
• https://www.ncbi.nlm.nih.gov/nuccore/NM_001195049
• https://www.ncbi.nlm.nih.gov/nuccore/NM_001195046
• https://www.ncbi.nlm.nih.gov/nuccore/NM_008778

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000031284

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.40035

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=300142

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• Rui-xin. Liu, et.al., p21-activated kinase 3 is overexpressed in thymic neuroendocrine tumors (carcinoids) with ectopic ACTH syndrome and participates in cell migration., Endocrine, 2010, 38
  http://rdf.ncbi.nlm.nih.gov/pubmed/20960100
• Wayne. Huang, et.al., p21-Activated kinases 1 and 3 control brain size through coordinating neuronal complexity and synaptic properties., Molecular and cellular biology, 2011, 31
  http://rdf.ncbi.nlm.nih.gov/pubmed/21115725
• Xiao-Sheng. Jiang, et.al., Activation of Rho GTPases in Smith-Lemli-Opitz syndrome: pathophysiological and clinical implications., Human molecular genetics, 2010, 19
  http://rdf.ncbi.nlm.nih.gov/pubmed/20067919
• S. Bagrodia, et.al., Identification of a mouse p21Cdc42/Rac activated kinase., The Journal of biological chemistry, 1995, 270
  http://rdf.ncbi.nlm.nih.gov/pubmed/7559398
• P D. Burbelo, et.al., Cloning, central nervous system expression and chromosomal mapping of the mouse PAK-1 and PAK-3 genes., Gene, 1999, 232
  http://rdf.ncbi.nlm.nih.gov/pubmed/10352232
• Tomomi. Shimogori, et.al., A genomic atlas of mouse hypothalamic development., Nature neuroscience, 2010, 13
  http://rdf.ncbi.nlm.nih.gov/pubmed/20436479
• T. Leeuw, et.al., Interaction of a G-protein beta-subunit with a conserved sequence in Ste20/PAK family protein kinases., Nature, 1998, 391
  http://rdf.ncbi.nlm.nih.gov/pubmed/9428767
• G A. Murphy, et.al., Cellular functions of TC10, a Rho family GTPase: regulation of morphology, signal transduction and cell growth., Oncogene, 1999, 18
  http://rdf.ncbi.nlm.nih.gov/pubmed/10445846
• Cynthia M. Grimsley-Myers, et.al., The small GTPase Rac1 regulates auditory hair cell morphogenesis., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, 29
  http://rdf.ncbi.nlm.nih.gov/pubmed/20016102
• P D. Burbelo, et.al., A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases., The Journal of biological chemistry, 1995, 270
  http://rdf.ncbi.nlm.nih.gov/pubmed/7493928

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• metal ion binding
  http://purl.obolibrary.org/obo/GO_0046872
• SH3 domain binding
  http://purl.obolibrary.org/obo/GO_0017124
• transferase activity, transferring phosphorus-containing groups
  http://purl.obolibrary.org/obo/GO_0016772
• phosphorylation
  http://purl.obolibrary.org/obo/GO_0016310
• Rho GTPase binding
  http://purl.obolibrary.org/obo/GO_0017048
• protein phosphorylation
  http://purl.obolibrary.org/obo/GO_0006468
• kinase activity
  http://purl.obolibrary.org/obo/GO_0016301
• dendrite development
  http://purl.obolibrary.org/obo/GO_0016358
• nucleotide binding
  http://purl.obolibrary.org/obo/GO_0000166
• MAP kinase kinase activity
  http://purl.obolibrary.org/obo/GO_0004708
• metabolic process
  http://purl.obolibrary.org/obo/GO_0008152
• catalytic activity
  http://purl.obolibrary.org/obo/GO_0003824
• protein kinase activity
  http://purl.obolibrary.org/obo/GO_0004672
• axonogenesis
  http://purl.obolibrary.org/obo/GO_0007409
• transferase activity
  http://purl.obolibrary.org/obo/GO_0016740
• regulation of actin filament polymerization
  http://purl.obolibrary.org/obo/GO_0030833
• GTPase binding
  http://purl.obolibrary.org/obo/GO_0051020
• protein serine/threonine kinase activity
  http://purl.obolibrary.org/obo/GO_0004674
• cytoplasm
  http://purl.obolibrary.org/obo/GO_0005737
• ATP binding
  http://purl.obolibrary.org/obo/GO_0005524

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map04810
• http://www.genome.jp/dbget-bin/www_bget?map04660
• http://www.genome.jp/dbget-bin/www_bget?map04510
• http://www.genome.jp/dbget-bin/www_bget?map04012
• http://www.genome.jp/dbget-bin/www_bget?map05211
• http://www.genome.jp/dbget-bin/www_bget?map04360

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• ErbB signaling pathway
• Regulation of actin cytoskeleton
• Renal cell carcinoma
• Focal adhesion
• T cell receptor signaling pathway
• Axon guidance