CD04756

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD04756

CD04756

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Pik3r2

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta)

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• ptdIns-3-kinase regulatory subunit beta
• PI3K regulatory subunit beta
• phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta
• ptdIns-3-kinase regulatory subunit p85-beta
• PI3-kinase regulatory subunit beta
• PI3-kinase subunit p85-beta
• phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta)
• phosphatidylinositol 3-kinase regulatory subunit beta

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• p85beta

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/18709

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• phosphoinositide-3-kinase regulatory subunit 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:1098772

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_008841

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000031834

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.12945

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=603157

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• L. Laviola, et.al., The adapter protein Grb10 associates preferentially with the insulin receptor as compared with the IGF-I receptor in mouse fibroblasts., The Journal of clinical investigation, 1997, 99
  http://rdf.ncbi.nlm.nih.gov/pubmed/9062339
• Jean S. Oak, et.al., The p85beta regulatory subunit of phosphoinositide 3-kinase has unique and redundant functions in B cells., Autoimmunity, 2009, 42
  http://rdf.ncbi.nlm.nih.gov/pubmed/19811262
• Sang Won. Park, et.al., The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation., Nature medicine, 2010, 16
  http://rdf.ncbi.nlm.nih.gov/pubmed/20348926
• Kazuma. Kaneko, et.al., Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanisms., Cell metabolism, 2010, 12
  http://rdf.ncbi.nlm.nih.gov/pubmed/21109194
• Rosalia. Rabinovsky, et.al., p85 Associates with unphosphorylated PTEN and the PTEN-associated complex., Molecular and cellular biology, 2009, 29
  http://rdf.ncbi.nlm.nih.gov/pubmed/19635806
• Ming-Cheng. Chang, et.al., Mesothelin inhibits paclitaxel-induced apoptosis through the PI3K pathway., The Biochemical journal, 2009, 424
  http://rdf.ncbi.nlm.nih.gov/pubmed/19747165
• S. Pons, et.al., The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase., Molecular and cellular biology, 1995, 15
  http://rdf.ncbi.nlm.nih.gov/pubmed/7542745
• J W. Janssen, et.al., An oncogenic fusion product of the phosphatidylinositol 3-kinase p85beta subunit and HUMORF8, a putative deubiquitinating enzyme., Oncogene, 1998, 16
  http://rdf.ncbi.nlm.nih.gov/pubmed/9582025
• T. Yamauchi, et.al., Growth hormone and prolactin stimulate tyrosine phosphorylation of insulin receptor substrate-1, -2, and -3, their association with p85 phosphatidylinositol 3-kinase (PI3-kinase), and concomitantly PI3-kinase activation via JAK2 kinase., The Journal of biological chemistry, 1998, 273
  http://rdf.ncbi.nlm.nih.gov/pubmed/9624169
• J V. Virbasius, et.al., Mouse p170 is a novel phosphatidylinositol 3-kinase containing a C2 domain., The Journal of biological chemistry, 1996, 271
  http://rdf.ncbi.nlm.nih.gov/pubmed/8663140

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• protein binding
  http://purl.obolibrary.org/obo/GO_0005515
• 1-phosphatidylinositol-3-kinase activity
  http://purl.obolibrary.org/obo/GO_0016303
• phosphatidylinositol 3-kinase complex
  http://purl.obolibrary.org/obo/GO_0005942
• intracellular
  http://purl.obolibrary.org/obo/GO_0005622
• insulin receptor signaling pathway
  http://purl.obolibrary.org/obo/GO_0008286
• signal transduction
  http://purl.obolibrary.org/obo/GO_0007165
• regulation of phosphorylation
  http://purl.obolibrary.org/obo/GO_0042325
• negative regulation of anti-apoptosis
  http://purl.obolibrary.org/obo/GO_0019987
• phosphatidylinositol 3-kinase regulator activity
  http://purl.obolibrary.org/obo/GO_0035014
• regulation of catalytic activity
  http://purl.obolibrary.org/obo/GO_0050790

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map00000

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Non-small cell lung cancer