CD04761

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD04761

CD04761

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Aspa

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• aspartoacylase

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• aminoacylase-2
• aspartoacylase (aminoacylase) 2
• aspartoacylase
• aminoacylase 2

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• small lethargic
• Acy2
• aspartoacylase
• nur7
• Acy-2

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/11484

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• aspartoacylase
  http://metadb.riken.jp/db/mgi_rdf/MGI:87914

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_023113

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000020774

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.293574

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=608034

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• Sankar. Surendran, et.al., Expression of glutamate transporter, GABRA6, serine proteinase inhibitor 2 and low levels of glutamate and GABA in the brain of knock-out mouse for Canavan disease., Brain research bulletin, 2003, 61
  http://rdf.ncbi.nlm.nih.gov/pubmed/12909286
• Roger A. Moore, et.al., Purification and preliminary characterization of brain aspartoacylase., Archives of biochemistry and biophysics, 2003, 413
  http://rdf.ncbi.nlm.nih.gov/pubmed/12706335
• http://rdf.ncbi.nlm.nih.gov/pubmed/10894262
• Melissa K. Boles, et.al., Discovery of candidate disease genes in ENU-induced mouse mutants by large-scale sequencing, including a splice-site mutation in nucleoredoxin., PLoS genetics, 2009, 5
  http://rdf.ncbi.nlm.nih.gov/pubmed/20011118
• Shalini. Kumar, et.al., Lack of aspartoacylase activity disrupts survival and differentiation of neural progenitors and oligodendrocytes in a mouse model of Canavan disease., Journal of neuroscience research, 2009, 87
  http://rdf.ncbi.nlm.nih.gov/pubmed/19739253
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• J H. Nadeau, A chromosomal segment conserved since divergence of lineages leading to man and mouse: the gene order of aminoacylase-1, transferrin, and beta-galactosidase on mouse chromosome 9., Genetical research, 1986, 48
  http://rdf.ncbi.nlm.nih.gov/pubmed/3106151
• M A. Namboodiri, et.al., Murine aspartoacylase: cloning, expression and comparison with the human enzyme., Brain research. Molecular brain research, 2000, 77
  http://rdf.ncbi.nlm.nih.gov/pubmed/10837925
• Natalia S. Mattan, et.al., Aspartoacylase deficiency affects early postnatal development of oligodendrocytes and myelination., Neurobiology of disease, 2010, 40
  http://rdf.ncbi.nlm.nih.gov/pubmed/20637282
• Maria. Traka, et.al., Nur7 is a nonsense mutation in the mouse aspartoacylase gene that causes spongy degeneration of the CNS., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, 28
  http://rdf.ncbi.nlm.nih.gov/pubmed/18987190

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• metabolic process
  http://purl.obolibrary.org/obo/GO_0008152
• hydrolase activity, acting on ester bonds
  http://purl.obolibrary.org/obo/GO_0016788
• cytoplasm
  http://purl.obolibrary.org/obo/GO_0005737
• positive regulation of oligodendrocyte differentiation
  http://purl.obolibrary.org/obo/GO_0048714
• nucleus
  http://purl.obolibrary.org/obo/GO_0005634
• aspartoacylase activity
  http://purl.obolibrary.org/obo/GO_0019807
• acetate metabolic process
  http://purl.obolibrary.org/obo/GO_0006083
• hydrolase activity
  http://purl.obolibrary.org/obo/GO_0016787
• metal ion binding
  http://purl.obolibrary.org/obo/GO_0046872
• aminoacylase activity
  http://purl.obolibrary.org/obo/GO_0004046
• hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
  http://purl.obolibrary.org/obo/GO_0016811

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map00340
• http://www.genome.jp/dbget-bin/www_bget?map00250

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• aspartate and glutamate metabolism
• Histidine metabolism
• Alanine