CD04930

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD04930

CD04930

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Bcl10

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• B-cell leukemia/lymphoma 10

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• CED-3/ICH-1 prodomain homologous E10-like regulator
• CARD-containing molecule enhancing NF-kappa-B
• mammalian CARD-containing adapter molecule E10
• mCIPER
• B-cell CLL/lymphoma 10
• CARD-like apoptotic protein
• B-cell leukemia/lymphoma 10
• cellular homolog of vCARMEN
• cellular-E10
• c-E10
• mCLAP
• cCARMEN
• B-cell lymphoma/leukemia 10

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• C81403
• AI132454
• BCL-10
• cE10
• CIPER
• mE10
• ME10
• CLAP
• CARMEN

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/12042

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• B cell leukemia/lymphoma 10
  http://metadb.riken.jp/db/mgi_rdf/MGI:1337994

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_009740

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000028191

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.239141

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=603517

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• Sumit. Bhattacharyya, et.al., Lipopolysaccharide-induced activation of NF-κB non-canonical pathway requires BCL10 serine 138 and NIK phosphorylations., Experimental cell research, 2010, 316
  http://rdf.ncbi.nlm.nih.gov/pubmed/20466000
• Phillip C. Delekta, et.al., Thrombin-dependent NF-{kappa}B activation and monocyte/endothelial adhesion are mediated by the CARMA3·Bcl10·MALT1 signalosome., The Journal of biological chemistry, 2010, 285
  http://rdf.ncbi.nlm.nih.gov/pubmed/21041303
• Liangkuan. Bi, et.al., CARD9 mediates dectin-2-induced IkappaBalpha kinase ubiquitination leading to activation of NF-kappaB in response to stimulation by the hyphal form of Candida albicans., The Journal of biological chemistry, 2010, 285
  http://rdf.ncbi.nlm.nih.gov/pubmed/20538615
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• T. Koseki, et.al., CIPER, a novel NF kappaB-activating protein containing a caspase recruitment domain with homology to Herpesvirus-2 protein E10., The Journal of biological chemistry, 1999, 274
  http://rdf.ncbi.nlm.nih.gov/pubmed/10187770
• S M. Srinivasula, et.al., CLAP, a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway, regulates NF-kappaB activation and apoptosis., The Journal of biological chemistry, 1999, 274
  http://rdf.ncbi.nlm.nih.gov/pubmed/10364242
• M. Yan, et.al., mE10, a novel caspase recruitment domain-containing proapoptotic molecule., The Journal of biological chemistry, 1999, 274
  http://rdf.ncbi.nlm.nih.gov/pubmed/10187815
• M. Thome, et.al., Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-kappaB transcription factor and c-Jun N-terminal kinase., The Journal of biological chemistry, 1999, 274
  http://rdf.ncbi.nlm.nih.gov/pubmed/10187771
• Linda M. McAllister-Lucas, et.al., The CARMA3-Bcl10-MALT1 signalosome promotes angiotensin II-dependent vascular inflammation and atherogenesis., The Journal of biological chemistry, 2010, 285
  http://rdf.ncbi.nlm.nih.gov/pubmed/20605784
• T G. Willis, et.al., Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types., Cell, 1999, 96
  http://rdf.ncbi.nlm.nih.gov/pubmed/9989495

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• enzyme binding
  http://purl.obolibrary.org/obo/GO_0019899
• immunological synapse
  http://purl.obolibrary.org/obo/GO_0001772
• macromolecular complex
  http://purl.obolibrary.org/obo/GO_0032991
• cytoplasm
  http://purl.obolibrary.org/obo/GO_0005737
• response to fungus
  http://purl.obolibrary.org/obo/GO_0009620
• ubiquitin protein ligase binding
  http://purl.obolibrary.org/obo/GO_0031625
• activation of cysteine-type endopeptidase activity
  http://purl.obolibrary.org/obo/GO_0097202
• protein binding
  http://purl.obolibrary.org/obo/GO_0005515
• positive regulation of T cell activation
  http://purl.obolibrary.org/obo/GO_0050870
• positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
  http://purl.obolibrary.org/obo/GO_0043280
• neural tube closure
  http://purl.obolibrary.org/obo/GO_0001843
• protein C-terminus binding
  http://purl.obolibrary.org/obo/GO_0008022
• I-kappaB kinase/NF-kappaB signaling
  http://purl.obolibrary.org/obo/GO_0007249
• intracellular
  http://purl.obolibrary.org/obo/GO_0005622
• protein homodimerization activity
  http://purl.obolibrary.org/obo/GO_0042803
• cytosol
  http://purl.obolibrary.org/obo/GO_0005829
• protein oligomerization
  http://purl.obolibrary.org/obo/GO_0051259
• protein homooligomerization
  http://purl.obolibrary.org/obo/GO_0051260
• perinuclear region of cytoplasm
  http://purl.obolibrary.org/obo/GO_0048471
• protein kinase B binding
  http://purl.obolibrary.org/obo/GO_0043422
• apoptotic process
  http://purl.obolibrary.org/obo/GO_0006915
• immunoglobulin mediated immune response
  http://purl.obolibrary.org/obo/GO_0016064
• cellular defense response
  http://purl.obolibrary.org/obo/GO_0006968
• cysteine-type endopeptidase activator activity involved in apoptotic process
  http://purl.obolibrary.org/obo/GO_0008656
• lysosome
  http://purl.obolibrary.org/obo/GO_0005764
• membrane raft
  http://purl.obolibrary.org/obo/GO_0045121
• positive regulation of interleukin-8 biosynthetic process
  http://purl.obolibrary.org/obo/GO_0045416
• transcription factor binding
  http://purl.obolibrary.org/obo/GO_0008134
• transcription coactivator activity
  http://purl.obolibrary.org/obo/GO_0003713
• T cell receptor signaling pathway
  http://purl.obolibrary.org/obo/GO_0050852
• protein kinase binding
  http://purl.obolibrary.org/obo/GO_0019901
• kinase binding
  http://purl.obolibrary.org/obo/GO_0019900
• positive regulation of transcription, DNA-templated
  http://purl.obolibrary.org/obo/GO_0045893
• NF-kappaB binding
  http://purl.obolibrary.org/obo/GO_0051059
• protein heterodimerization activity
  http://purl.obolibrary.org/obo/GO_0046982
• membrane
  http://purl.obolibrary.org/obo/GO_0016020
• response to chemical
  http://purl.obolibrary.org/obo/GO_0042221
• protease binding
  http://purl.obolibrary.org/obo/GO_0002020
• nucleus
  http://purl.obolibrary.org/obo/GO_0005634
• cell death
  http://purl.obolibrary.org/obo/GO_0008219
• regulation of apoptotic process
  http://purl.obolibrary.org/obo/GO_0042981
• mast cell activation
  http://purl.obolibrary.org/obo/GO_0045576
• activation of JUN kinase activity
  http://purl.obolibrary.org/obo/GO_0007257
• regulation of T cell receptor signaling pathway
  http://purl.obolibrary.org/obo/GO_0050856
• activation of cysteine-type endopeptidase activity involved in apoptotic process
  http://purl.obolibrary.org/obo/GO_0006919
• positive regulation of phosphorylation
  http://purl.obolibrary.org/obo/GO_0042327
• negative regulation of mature B cell apoptotic process
  http://purl.obolibrary.org/obo/GO_0002906
• positive regulation of protein ubiquitination
  http://purl.obolibrary.org/obo/GO_0031398
• positive regulation of NF-kappaB transcription factor activity
  http://purl.obolibrary.org/obo/GO_0051092
• protein heterooligomerization
  http://purl.obolibrary.org/obo/GO_0051291
• ubiquitin binding
  http://purl.obolibrary.org/obo/GO_0043130
• protein self-association
  http://purl.obolibrary.org/obo/GO_0043621

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map04660
• http://www.genome.jp/dbget-bin/www_bget?map05152
• http://www.genome.jp/dbget-bin/www_bget?map04662

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• T cell receptor signaling pathway
• B cell receptor signaling pathway
• Tuberculosis