CD04954

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD04954

CD04954

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Fads2

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• fatty acid desaturase 2

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• delta-6 desaturase
• delta(6) fatty acid desaturase
• delta-6 fatty acid desaturase
• D6D
• fatty acid desaturase 2
• delta(6) desaturase

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• 2900042M13Rik
• Fadsd2

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/56473

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• fatty acid desaturase 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:1930079

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_019699

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000024665

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.38901

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=606149

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• http://rdf.ncbi.nlm.nih.gov/pubmed/18685602
• Chad K. Stroud, et.al., Disruption of FADS2 gene in mice impairs male reproduction and causes dermal and intestinal ulceration., Journal of lipid research, 2009, 50
  http://rdf.ncbi.nlm.nih.gov/pubmed/19351970
• H P. Cho, et.al., Cloning, expression, and nutritional regulation of the mammalian Delta-6 desaturase., The Journal of biological chemistry, 1999, 274
  http://rdf.ncbi.nlm.nih.gov/pubmed/9867867
• Mira. Rosenblat, et.al., Increased macrophage cholesterol biosynthesis and decreased cellular paraoxonase 2 (PON2) expression in Delta6-desaturase knockout (6-DS KO) mice: beneficial effects of arachidonic acid., Atherosclerosis, 2010, 210
  http://rdf.ncbi.nlm.nih.gov/pubmed/20042190
• A. Marquardt, et.al., cDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty acid desaturase family., Genomics, 2000, 66
  http://rdf.ncbi.nlm.nih.gov/pubmed/10860662
• Wilhelm. Stoffel, et.al., Delta6-desaturase (FADS2) deficiency unveils the role of omega3- and omega6-polyunsaturated fatty acids., The EMBO journal, 2008, 27
  http://rdf.ncbi.nlm.nih.gov/pubmed/19172737
• Angela M. Devlin, et.al., Hypermethylation of Fads2 and altered hepatic fatty acid and phospholipid metabolism in mice with hyperhomocysteinemia., The Journal of biological chemistry, 2007, 282
  http://rdf.ncbi.nlm.nih.gov/pubmed/17971455
• Manuel. Roqueta-Rivera, et.al., Docosahexaenoic acid supplementation fully restores fertility and spermatogenesis in male delta-6 desaturase-null mice., Journal of lipid research, 2010, 51
  http://rdf.ncbi.nlm.nih.gov/pubmed/19690334
• Kimberly M. Hargrave-Barnes, et.al., Conjugated linoleic acid-induced fat loss dependence on Delta6-desaturase or cyclooxygenase., Obesity (Silver Spring, Md.), 2008, 16
  http://rdf.ncbi.nlm.nih.gov/pubmed/18719641

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• iron ion binding
  http://purl.obolibrary.org/obo/GO_0005506
• lipid biosynthetic process
  http://purl.obolibrary.org/obo/GO_0008610
• integral component of membrane
  http://purl.obolibrary.org/obo/GO_0016021
• membrane fraction
  http://purl.obolibrary.org/obo/GO_0005624
• transport
  http://purl.obolibrary.org/obo/GO_0006810
• oxidoreductase activity
  http://purl.obolibrary.org/obo/GO_0016491
• heme binding
  http://purl.obolibrary.org/obo/GO_0020037
• fatty acid biosynthetic process
  http://purl.obolibrary.org/obo/GO_0006633
• oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
  http://purl.obolibrary.org/obo/GO_0016717
• electron transport chain
  http://purl.obolibrary.org/obo/GO_0022900
• lipid metabolic process
  http://purl.obolibrary.org/obo/GO_0006629
• stearoyl-CoA 9-desaturase activity
  http://purl.obolibrary.org/obo/GO_0004768
• endoplasmic reticulum
  http://purl.obolibrary.org/obo/GO_0005783
• membrane
  http://purl.obolibrary.org/obo/GO_0016020

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map01040
• http://www.genome.jp/dbget-bin/www_bget?map03320
• http://www.genome.jp/dbget-bin/www_bget?map00592

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Biosynthesis of unsaturated fatty acids
• PPAR signaling pathway
• alpha-Linolenic acid metabolism