CD05582

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD05582

CD05582

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Fgfr3

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• fibroblast growth factor receptor 3

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• fibroblast growth factor receptor 3
• heparin-binding growth factor receptor

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• sam3
• FR3
• HBGFR
• Fgfr-3
• CD333
• Mfr3
• Flg-2

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/14184

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• fibroblast growth factor receptor 3
  http://metadb.riken.jp/db/mgi_rdf/MGI:95524

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_001163217
• https://www.ncbi.nlm.nih.gov/nuccore/NM_001163215
• https://www.ncbi.nlm.nih.gov/nuccore/NM_001205270
• https://www.ncbi.nlm.nih.gov/nuccore/NM_001163216
• https://www.ncbi.nlm.nih.gov/nuccore/NM_008010

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000054252

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.6904

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=134934

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• A T. Chellaiah, et.al., Fibroblast growth factor receptor (FGFR) 3. Alternative splicing in immunoglobulin-like domain III creates a receptor highly specific for acidic FGF/FGF-1., The Journal of biological chemistry, 1994, 269
  http://rdf.ncbi.nlm.nih.gov/pubmed/7512569
• H. Nagase, et.al., Distinct genetic loci control development of benign and malignant skin tumours in mice., Nature genetics, 1995, 10
  http://rdf.ncbi.nlm.nih.gov/pubmed/7670492
• Jolie L. Chang, et.al., Tissue-specific calibration of extracellular matrix material properties by transforming growth factor-β and Runx2 in bone is required for hearing., EMBO reports, 2010, 11
  http://rdf.ncbi.nlm.nih.gov/pubmed/20847738
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• Laura. Lahti, et.al., FGF signaling gradient maintains symmetrical proliferative divisions of midbrain neuronal progenitors., Developmental biology, 2011, 349
  http://rdf.ncbi.nlm.nih.gov/pubmed/21074523
• D M. Ornitz, et.al., Ligand specificity and heparin dependence of fibroblast growth factor receptors 1 and 3., The Journal of biological chemistry, 1992, 267
  http://rdf.ncbi.nlm.nih.gov/pubmed/1379594
• http://rdf.ncbi.nlm.nih.gov/pubmed/20934536
• G A. Bellus, et.al., A recurrent mutation in the tyrosine kinase domain of fibroblast growth factor receptor 3 causes hypochondroplasia., Nature genetics, 1995, 10
  http://rdf.ncbi.nlm.nih.gov/pubmed/7670477
• A. Avivi, et.al., Flg-2, a new member of the family of fibroblast growth factor receptors., Oncogene, 1991, 6
  http://rdf.ncbi.nlm.nih.gov/pubmed/1648703
• Sabrina. Bimonte, et.al., Ofd1 is required in limb bud patterning and endochondral bone development., Developmental biology, 2011, 349
  http://rdf.ncbi.nlm.nih.gov/pubmed/20920500

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• negative regulation of apoptotic process
  http://purl.obolibrary.org/obo/GO_0043066
• oligodendrocyte development
  http://purl.obolibrary.org/obo/GO_0014003
• positive regulation of MAPK cascade
  http://purl.obolibrary.org/obo/GO_0043410
• cell differentiation
  http://purl.obolibrary.org/obo/GO_0030154
• nucleus
  http://purl.obolibrary.org/obo/GO_0005634
• protein autophosphorylation
  http://purl.obolibrary.org/obo/GO_0046777
• cell-cell signaling
  http://purl.obolibrary.org/obo/GO_0007267
• cargo receptor activity
  http://purl.obolibrary.org/obo/GO_0038024
• negative regulation of smoothened signaling pathway
  http://purl.obolibrary.org/obo/GO_0045879
• protein binding
  http://purl.obolibrary.org/obo/GO_0005515
• fibroblast growth factor binding
  http://purl.obolibrary.org/obo/GO_0017134
• cell surface
  http://purl.obolibrary.org/obo/GO_0009986
• positive regulation of phospholipase activity
  http://purl.obolibrary.org/obo/GO_0010518
• positive regulation of phosphatidylinositol 3-kinase activity
  http://purl.obolibrary.org/obo/GO_0043552
• ATP binding
  http://purl.obolibrary.org/obo/GO_0005524
• fibroblast growth factor-activated receptor activity
  http://purl.obolibrary.org/obo/GO_0005007
• lysosome
  http://purl.obolibrary.org/obo/GO_0005764
• central nervous system myelination
  http://purl.obolibrary.org/obo/GO_0022010
• transferase activity
  http://purl.obolibrary.org/obo/GO_0016740
• MAPK cascade
  http://purl.obolibrary.org/obo/GO_0000165
• alveolar secondary septum development
  http://purl.obolibrary.org/obo/GO_0061144
• integral component of membrane
  http://purl.obolibrary.org/obo/GO_0016021
• forebrain development
  http://purl.obolibrary.org/obo/GO_0030900
• positive regulation of protein ubiquitination
  http://purl.obolibrary.org/obo/GO_0031398
• cartilage development
  http://purl.obolibrary.org/obo/GO_0051216
• positive regulation of canonical Wnt signaling pathway
  http://purl.obolibrary.org/obo/GO_0090263
• kinase activity
  http://purl.obolibrary.org/obo/GO_0016301
• positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
  http://purl.obolibrary.org/obo/GO_0090080
• lens fiber cell development
  http://purl.obolibrary.org/obo/GO_0070307
• bone morphogenesis
  http://purl.obolibrary.org/obo/GO_0060349
• negative regulation of astrocyte differentiation
  http://purl.obolibrary.org/obo/GO_0048712
• response to axon injury
  http://purl.obolibrary.org/obo/GO_0048678
• membrane
  http://purl.obolibrary.org/obo/GO_0016020
• positive regulation of cell proliferation
  http://purl.obolibrary.org/obo/GO_0008284
• regulation of apoptotic process
  http://purl.obolibrary.org/obo/GO_0042981
• phosphorylation
  http://purl.obolibrary.org/obo/GO_0016310
• protein tyrosine kinase activity
  http://purl.obolibrary.org/obo/GO_0004713
• nucleotide binding
  http://purl.obolibrary.org/obo/GO_0000166
• morphogenesis of an epithelium
  http://purl.obolibrary.org/obo/GO_0002009
• negative regulation of mitotic nuclear division
  http://purl.obolibrary.org/obo/GO_0045839
• positive regulation of cell differentiation
  http://purl.obolibrary.org/obo/GO_0045597
• substantia nigra development
  http://purl.obolibrary.org/obo/GO_0021762
• integral component of plasma membrane
  http://purl.obolibrary.org/obo/GO_0005887
• cytoplasmic side of plasma membrane
  http://purl.obolibrary.org/obo/GO_0009898
• peptidyl-tyrosine phosphorylation
  http://purl.obolibrary.org/obo/GO_0018108
• positive regulation of peptidyl-tyrosine phosphorylation
  http://purl.obolibrary.org/obo/GO_0050731
• inner ear development
  http://purl.obolibrary.org/obo/GO_0048839
• cytoplasm
  http://purl.obolibrary.org/obo/GO_0005737
• positive regulation of ERK1 and ERK2 cascade
  http://purl.obolibrary.org/obo/GO_0070374
• positive regulation of endothelial cell proliferation
  http://purl.obolibrary.org/obo/GO_0001938
• perinuclear region of cytoplasm
  http://purl.obolibrary.org/obo/GO_0048471
• negative regulation of cell proliferation
  http://purl.obolibrary.org/obo/GO_0008285
• negative regulation of transcription from RNA polymerase II promoter
  http://purl.obolibrary.org/obo/GO_0000122
• signaling receptor activity
  http://purl.obolibrary.org/obo/GO_0038023
• axonogenesis involved in innervation
  http://purl.obolibrary.org/obo/GO_0060385
• transmembrane receptor protein tyrosine kinase activity
  http://purl.obolibrary.org/obo/GO_0004714
• lens morphogenesis in camera-type eye
  http://purl.obolibrary.org/obo/GO_0002089
• fibroblast growth factor receptor signaling pathway
  http://purl.obolibrary.org/obo/GO_0008543
• cochlea development
  http://purl.obolibrary.org/obo/GO_0090102
• positive regulation of apoptotic process
  http://purl.obolibrary.org/obo/GO_0043065
• epithelial cell fate commitment
  http://purl.obolibrary.org/obo/GO_0072148
• negative regulation of epithelial cell proliferation
  http://purl.obolibrary.org/obo/GO_0050680
• inner ear receptor cell differentiation
  http://purl.obolibrary.org/obo/GO_0060113
• digestive tract morphogenesis
  http://purl.obolibrary.org/obo/GO_0048546
• positive regulation of tyrosine phosphorylation of STAT protein
  http://purl.obolibrary.org/obo/GO_0042531

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map04010
• http://www.genome.jp/dbget-bin/www_bget?map04144
• http://www.genome.jp/dbget-bin/www_bget?map05219
• http://www.genome.jp/dbget-bin/www_bget?map04810
• http://www.genome.jp/dbget-bin/www_bget?map05200

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Regulation of actin cytoskeleton
• Bladder cancer
• Pathways in cancer
• Endocytosis
• MAPK signaling pathway