CD05729

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD05729

CD05729

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Smad4

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• MAD homolog 4 (Drosophila)

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• mothers against decapentaplegic homolog 4
• deletion target in pancreatic carcinoma 4 homolog
• MAD homolog 4 (Drosophila)
• mothers against DPP homolog 4
• SMAD family member 4

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• Madh4
• AW743858
• Smad 4
• D18Wsu70e
• Dpc4
• DPC4

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/17128

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• SMAD family member 4
  http://metadb.riken.jp/db/mgi_rdf/MGI:894293

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_008540

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000024515

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.100399

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=600993

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• Susana. da Silva, et.al., Proper formation of whisker barrelettes requires periphery-derived Smad4-dependent TGF-beta signaling., Proceedings of the National Academy of Sciences of the United States of America, 2011, 108
  http://rdf.ncbi.nlm.nih.gov/pubmed/21300867
• C H. Anna, et.al., Sequence and chromosomal mapping of the mouse homolog (Madh4) of the human DPC4/MADH4 gene., Mammalian genome : official journal of the International Mammalian Genome Society, 1997, 8
  http://rdf.ncbi.nlm.nih.gov/pubmed/9166592
• C H. Heldin, et.al., TGF-beta signalling from cell membrane to nucleus through SMAD proteins., Nature, 1997, 390
  http://rdf.ncbi.nlm.nih.gov/pubmed/9393997
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• T R. Devereux, et.al., Smad4 (homolog of human DPC4) and Smad2 (homolog of human JV18-1): candidates for murine lung tumor resistance and suppressor genes., Carcinogenesis, 1997, 18
  http://rdf.ncbi.nlm.nih.gov/pubmed/9328171
• Cuiling. Li, et.al., Anterior visceral endoderm SMAD4 signaling specifies anterior embryonic patterning and head induction in mice., International journal of biological sciences, 2010, 6
  http://rdf.ncbi.nlm.nih.gov/pubmed/20941375
• Langying. Song, et.al., Cell autonomous requirement of endocardial Smad4 during atrioventricular cushion development in mouse embryos., Developmental dynamics : an official publication of the American Association of Anatomists, 2011, 240
  http://rdf.ncbi.nlm.nih.gov/pubmed/21089072
• C. Sirard, et.al., The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo., Genes & development, 1998, 12
  http://rdf.ncbi.nlm.nih.gov/pubmed/9420335
• Zhihu. Ding, et.al., SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression., Nature, 2011, 470
  http://rdf.ncbi.nlm.nih.gov/pubmed/21289624
• X. Chen, et.al., Smad4 and FAST-1 in the assembly of activin-responsive factor., Nature, 1997, 389
  http://rdf.ncbi.nlm.nih.gov/pubmed/9288972

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• positive regulation of transforming growth factor beta receptor signaling pathway
  http://purl.obolibrary.org/obo/GO_0030511
• neuron fate commitment
  http://purl.obolibrary.org/obo/GO_0048663
• identical protein binding
  http://purl.obolibrary.org/obo/GO_0042802
• macromolecular complex
  http://purl.obolibrary.org/obo/GO_0032991
• response to hypoxia
  http://purl.obolibrary.org/obo/GO_0001666
• sequence-specific DNA binding transcription factor activity
  http://purl.obolibrary.org/obo/GO_0003700
• BMP signaling pathway
  http://purl.obolibrary.org/obo/GO_0030509
• cytoplasm
  http://purl.obolibrary.org/obo/GO_0005737
• negative regulation of protein catabolic process
  http://purl.obolibrary.org/obo/GO_0042177
• negative regulation of cell growth
  http://purl.obolibrary.org/obo/GO_0030308
• core promoter proximal region sequence-specific DNA binding
  http://purl.obolibrary.org/obo/GO_0000987
• regulation of transcription, DNA-templated
  http://purl.obolibrary.org/obo/GO_0006355
• positive regulation of transcription from RNA polymerase II promoter
  http://purl.obolibrary.org/obo/GO_0045944
• activin responsive factor complex
  http://purl.obolibrary.org/obo/GO_0032444
• R-SMAD binding
  http://purl.obolibrary.org/obo/GO_0070412
• transcription regulatory region DNA binding
  http://purl.obolibrary.org/obo/GO_0044212
• negative regulation of transcription, DNA-templated
  http://purl.obolibrary.org/obo/GO_0045892
• SMAD protein signal transduction
  http://purl.obolibrary.org/obo/GO_0060395
• protein binding
  http://purl.obolibrary.org/obo/GO_0005515
• collagen binding
  http://purl.obolibrary.org/obo/GO_0005518
• somite rostral/caudal axis specification
  http://purl.obolibrary.org/obo/GO_0032525
• negative regulation of cell death
  http://purl.obolibrary.org/obo/GO_0060548
• branching involved in ureteric bud morphogenesis
  http://purl.obolibrary.org/obo/GO_0001658
• protein homodimerization activity
  http://purl.obolibrary.org/obo/GO_0042803
• formation of anatomical boundary
  http://purl.obolibrary.org/obo/GO_0048859
• chromatin binding
  http://purl.obolibrary.org/obo/GO_0003682
• regulation of transforming growth factor beta2 production
  http://purl.obolibrary.org/obo/GO_0032909
• positive regulation of epithelial to mesenchymal transition
  http://purl.obolibrary.org/obo/GO_0010718
• positive regulation of pathway-restricted SMAD protein phosphorylation
  http://purl.obolibrary.org/obo/GO_0010862
• anterior/posterior pattern specification
  http://purl.obolibrary.org/obo/GO_0009952
• metanephric mesenchyme morphogenesis
  http://purl.obolibrary.org/obo/GO_0072133
• response to transforming growth factor beta
  http://purl.obolibrary.org/obo/GO_0071559
• negative regulation of cell proliferation
  http://purl.obolibrary.org/obo/GO_0008285
• intracellular
  http://purl.obolibrary.org/obo/GO_0005622
• regulation of hair follicle development
  http://purl.obolibrary.org/obo/GO_0051797
• regulation of cell proliferation
  http://purl.obolibrary.org/obo/GO_0042127
• tissue morphogenesis
  http://purl.obolibrary.org/obo/GO_0048729
• I-SMAD binding
  http://purl.obolibrary.org/obo/GO_0070411
• positive regulation of transcription, DNA-templated
  http://purl.obolibrary.org/obo/GO_0045893
• regulation of binding
  http://purl.obolibrary.org/obo/GO_0051098
• regulation of transforming growth factor beta receptor signaling pathway
  http://purl.obolibrary.org/obo/GO_0017015
• nucleus
  http://purl.obolibrary.org/obo/GO_0005634
• in utero embryonic development
  http://purl.obolibrary.org/obo/GO_0001701
• neural crest cell differentiation
  http://purl.obolibrary.org/obo/GO_0014033
• regulation of transcription from RNA polymerase II promoter
  http://purl.obolibrary.org/obo/GO_0006357
• endoderm development
  http://purl.obolibrary.org/obo/GO_0007492
• mesoderm development
  http://purl.obolibrary.org/obo/GO_0007498
• sebaceous gland development
  http://purl.obolibrary.org/obo/GO_0048733
• kidney development
  http://purl.obolibrary.org/obo/GO_0001822
• transcription factor complex
  http://purl.obolibrary.org/obo/GO_0005667
• SMAD protein complex assembly
  http://purl.obolibrary.org/obo/GO_0007183
• cell proliferation
  http://purl.obolibrary.org/obo/GO_0008283
• gastrulation with mouth forming second
  http://purl.obolibrary.org/obo/GO_0001702
• developmental growth
  http://purl.obolibrary.org/obo/GO_0048589
• transforming growth factor beta receptor, common-partner cytoplasmic mediator activity
  http://purl.obolibrary.org/obo/GO_0030616
• transcription, DNA-templated
  http://purl.obolibrary.org/obo/GO_0006351
• SMAD protein complex
  http://purl.obolibrary.org/obo/GO_0071141
• nephrogenic mesenchyme morphogenesis
  http://purl.obolibrary.org/obo/GO_0072134
• gastrulation
  http://purl.obolibrary.org/obo/GO_0007369
• transforming growth factor beta receptor signaling pathway
  http://purl.obolibrary.org/obo/GO_0007179
• positive regulation of SMAD protein import into nucleus
  http://purl.obolibrary.org/obo/GO_0060391
• centrosome
  http://purl.obolibrary.org/obo/GO_0005813
• SMAD binding
  http://purl.obolibrary.org/obo/GO_0046332
• DNA binding
  http://purl.obolibrary.org/obo/GO_0003677

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map04110
• http://www.genome.jp/dbget-bin/www_bget?map04310
• http://www.genome.jp/dbget-bin/www_bget?map05220
• http://www.genome.jp/dbget-bin/www_bget?map05212
• http://www.genome.jp/dbget-bin/www_bget?map05200
• http://www.genome.jp/dbget-bin/www_bget?map04350
• http://www.genome.jp/dbget-bin/www_bget?map05166
• http://www.genome.jp/dbget-bin/www_bget?map05210
• http://www.genome.jp/dbget-bin/www_bget?map04520

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Adherens junction
• TGF-beta signaling pathway
• Pancreatic cancer
• Chronic myeloid leukemia
• Pathways in cancer
• Wnt signaling pathway
• HTLV-I infection
• Cell cycle
• Colorectal cancer