CD05794

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD05794

CD05794

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Rasgrf1

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• RAS protein-specific guanine nucleotide-releasing factor 1

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• ras-specific nucleotide exchange factor CDC25
• ras-specific guanine nucleotide-releasing factor 1
• RAS protein-specific guanine nucleotide-releasing factor 1
• guanine nucleotide releasing factor 1
• guanine nucleotide-releasing protein
• GNRP
• Ras guanine release factor beta
• GRF beta

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• P190-A
• Grf1
• CDC25Mm
• p190
• AI844718
• CDC25
• Ras-GRF1
• p190RhoGEF
• Grfbeta

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/19417

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• RAS protein-specific guanine nucleotide-releasing factor 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:99694

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_011245
• https://www.ncbi.nlm.nih.gov/nuccore/NM_001039655

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000032356

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.44561

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=606600

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• Chelsea M. Brideau, et.al., A non-coding RNA within the Rasgrf1 locus in mouse is imprinted and regulated by its homologous chromosome in trans., PloS one, 2010, 5
  http://rdf.ncbi.nlm.nih.gov/pubmed/21072176
• E. Martegani, et.al., Cloning by functional complementation of a mouse cDNA encoding a homologue of CDC25, a Saccharomyces cerevisiae RAS activator., The EMBO journal, 1992, 11
  http://rdf.ncbi.nlm.nih.gov/pubmed/1376246
• M. Gariboldi, et.al., Genetic mapping of the mouse CDC25Mm gene, a ras-specific guanine nucleotide-releasing factor, to chromosome 9., Genomics, 1994, 21
  http://rdf.ncbi.nlm.nih.gov/pubmed/8088844
• Stefania. Fasano, et.al., Inhibition of Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) signaling in the striatum reverts motor symptoms associated with L-dopa-induced dyskinesia., Proceedings of the National Academy of Sciences of the United States of America, 2010, 107
  http://rdf.ncbi.nlm.nih.gov/pubmed/21115823
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• H. Cen, et.al., Isolation of multiple mouse cDNAs with coding homology to Saccharomyces cerevisiae CDC25: identification of a region related to Bcr, Vav, Dbl and CDC24., The EMBO journal, 1992, 11
  http://rdf.ncbi.nlm.nih.gov/pubmed/1396590
• W. Wei, et.al., Identification of a mammalian gene structurally and functionally related to the CDC25 gene of Saccharomyces cerevisiae., Proceedings of the National Academy of Sciences of the United States of America, 1992, 89
  http://rdf.ncbi.nlm.nih.gov/pubmed/1379731
• H. Cen, et.al., Regulated and constitutive activity by CDC25Mm (GRF), a Ras-specific exchange factor., Molecular and cellular biology, 1993, 13
  http://rdf.ncbi.nlm.nih.gov/pubmed/8246988
• Pirro G. Hysi, et.al., A genome-wide association study for myopia and refractive error identifies a susceptibility locus at 15q25., Nature genetics, 2010, 42
  http://rdf.ncbi.nlm.nih.gov/pubmed/20835236
• Shan-xue. Jin, et.al., Long-term potentiation in the CA1 hippocampus induced by NR2A subunit-containing NMDA glutamate receptors is mediated by Ras-GRF2/Erk map kinase signaling., PloS one, 2010, 5
  http://rdf.ncbi.nlm.nih.gov/pubmed/20661302

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• growth cone
  http://purl.obolibrary.org/obo/GO_0030426
• regulation of Rac protein signal transduction
  http://purl.obolibrary.org/obo/GO_0035020
• neuron projection development
  http://purl.obolibrary.org/obo/GO_0031175
• regulation of Rho protein signal transduction
  http://purl.obolibrary.org/obo/GO_0035023
• protein binding
  http://purl.obolibrary.org/obo/GO_0005515
• intracellular
  http://purl.obolibrary.org/obo/GO_0005622
• cell proliferation
  http://purl.obolibrary.org/obo/GO_0008283
• Rho guanyl-nucleotide exchange factor activity
  http://purl.obolibrary.org/obo/GO_0005089
• glutamate receptor binding
  http://purl.obolibrary.org/obo/GO_0035254
• guanyl-nucleotide exchange factor activity
  http://purl.obolibrary.org/obo/GO_0005085
• regulation of small GTPase mediated signal transduction
  http://purl.obolibrary.org/obo/GO_0051056
• positive regulation of GTPase activity
  http://purl.obolibrary.org/obo/GO_0043547
• regulation of Ras protein signal transduction
  http://purl.obolibrary.org/obo/GO_0046578
• activation of GTPase activity
  http://purl.obolibrary.org/obo/GO_0090630
• small GTPase mediated signal transduction
  http://purl.obolibrary.org/obo/GO_0007264
• cytosol
  http://purl.obolibrary.org/obo/GO_0005829
• intracellular signal transduction
  http://purl.obolibrary.org/obo/GO_0035556
• regulation of catalytic activity
  http://purl.obolibrary.org/obo/GO_0050790
• regulation of neuronal synaptic plasticity
  http://purl.obolibrary.org/obo/GO_0048168

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map04010
• http://www.genome.jp/dbget-bin/www_bget?map04510

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• MAPK signaling pathway
• Focal adhesion