CD05804

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD05804

CD05804

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Map4k4

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• mitogen-activated protein kinase kinase kinase kinase 4

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• HPK/GCK-like kinase HGK
• NCK interacting kinase
• nck-interacting kinase
• mitogen-activated protein kinase kinase kinase kinase 4
• MEKKK 4
• mitogen activated protein kinase kinase kinase kinase 4
• MEK kinase kinase 4
• MAPK/ERK kinase kinase kinase 4

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• AW046177
• AU043147
• AU045934
• HGK
• 9430080K19Rik
• Nik

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/26921

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• mitogen-activated protein kinase kinase kinase kinase 4
  http://metadb.riken.jp/db/mgi_rdf/MGI:1349394

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_001252200
• https://www.ncbi.nlm.nih.gov/nuccore/NM_008696
• https://www.ncbi.nlm.nih.gov/nuccore/NM_001252202
• https://www.ncbi.nlm.nih.gov/nuccore/NM_001252201

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000026074

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.485049

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=604666

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• Myriam. Aouadi, et.al., Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation., Nature, 2009, 458
  http://rdf.ncbi.nlm.nih.gov/pubmed/19407801
• K. Araki, et.al., Exchangeable gene trap using the Cre/mutated lox system., Cellular and molecular biology (Noisy-le-Grand, France), 1999, 45
  http://rdf.ncbi.nlm.nih.gov/pubmed/10512203
• Y C. Su, et.al., NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain., The EMBO journal, 1997, 16
  http://rdf.ncbi.nlm.nih.gov/pubmed/9135144
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• E. Becker, et.al., Nck-interacting Ste20 kinase couples Eph receptors to c-Jun N-terminal kinase and integrin activation., Molecular and cellular biology, 2000, 20
  http://rdf.ncbi.nlm.nih.gov/pubmed/10669731
• Kalyani V P. Guntur, et.al., Map4k4 negatively regulates peroxisome proliferator-activated receptor (PPAR) gamma protein translation by suppressing the mammalian target of rapamycin (mTOR) signaling pathway in cultured adipocytes., The Journal of biological chemistry, 2010, 285
  http://rdf.ncbi.nlm.nih.gov/pubmed/20038583
• Toshimasa. Maruyama, et.al., Processing of the NF-kappa B2 precursor p100 to p52 is critical for RANKL-induced osteoclast differentiation., Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2010, 25
  http://rdf.ncbi.nlm.nih.gov/pubmed/19874202
• Y. Xue, et.al., Mesodermal patterning defect in mice lacking the Ste20 NCK interacting kinase (NIK)., Development (Cambridge, England), 2001, 128
  http://rdf.ncbi.nlm.nih.gov/pubmed/11290295
• Tobias. Wittwer, et.al., NIK and Cot cooperate to trigger NF-kappaB p65 phosphorylation., Biochemical and biophysical research communications, 2008, 371
  http://rdf.ncbi.nlm.nih.gov/pubmed/18439422
• Patrice. Poinat, et.al., A conserved interaction between beta1 integrin/PAT-3 and Nck-interacting kinase/MIG-15 that mediates commissural axon navigation in C. elegans., Current biology : CB, 2002, 12
  http://rdf.ncbi.nlm.nih.gov/pubmed/11967148

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• phosphorylation
  http://purl.obolibrary.org/obo/GO_0016310
• transferase activity, transferring phosphorus-containing groups
  http://purl.obolibrary.org/obo/GO_0016772
• protein kinase activity
  http://purl.obolibrary.org/obo/GO_0004672
• protein phosphorylation
  http://purl.obolibrary.org/obo/GO_0006468
• cytoplasm
  http://purl.obolibrary.org/obo/GO_0005737
• response to stress
  http://purl.obolibrary.org/obo/GO_0006950
• ATP binding
  http://purl.obolibrary.org/obo/GO_0005524
• nucleotide binding
  http://purl.obolibrary.org/obo/GO_0000166
• regulation of catalytic activity
  http://purl.obolibrary.org/obo/GO_0050790
• transferase activity
  http://purl.obolibrary.org/obo/GO_0016740
• intracellular signal transduction
  http://purl.obolibrary.org/obo/GO_0035556
• intracellular
  http://purl.obolibrary.org/obo/GO_0005622
• regulation of JNK cascade
  http://purl.obolibrary.org/obo/GO_0046328
• kinase activity
  http://purl.obolibrary.org/obo/GO_0016301
• protein serine/threonine kinase activity
  http://purl.obolibrary.org/obo/GO_0004674
• GTPase regulator activity
  http://purl.obolibrary.org/obo/GO_0030695

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map04010

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• MAPK signaling pathway