CD06082

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD06082

CD06082

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Bbc3

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• BCL2 binding component 3

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• Bcl-2 binding component 3
• BH3-only
• p53 up-regulated modulator of apoptosis
• BCL2 binding component 3
• bcl-2-binding component 3

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• PUMA
• PUMA/JFY1

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/170770

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• BCL2 binding component 3
  http://metadb.riken.jp/db/mgi_rdf/MGI:2181667

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_133234

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000002083

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.7660

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=605854

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• John R. Jeffers, et.al., Puma is an essential mediator of p53-dependent and -independent apoptotic pathways., Cancer cell, 2003, 4
  http://rdf.ncbi.nlm.nih.gov/pubmed/14585359
• Michael T. Hemann, et.al., Suppression of tumorigenesis by the p53 target PUMA., Proceedings of the National Academy of Sciences of the United States of America, 2004, 101
  http://rdf.ncbi.nlm.nih.gov/pubmed/15192153
• Hussein A. Abbas, et.al., Mdm2 is required for survival of hematopoietic stem cells/progenitors via dampening of ROS-induced p53 activity., Cell stem cell, 2010, 7
  http://rdf.ncbi.nlm.nih.gov/pubmed/21040902
• Zohreh. Galehdar, et.al., Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, 30
  http://rdf.ncbi.nlm.nih.gov/pubmed/21159964
• Sean P. Garrison, et.al., The p53-target gene puma drives neutrophil-mediated protection against lethal bacterial sepsis., PLoS pathogens, 2010, 6
  http://rdf.ncbi.nlm.nih.gov/pubmed/21203486
• J. Han, et.al., Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals., Proceedings of the National Academy of Sciences of the United States of America, 2001, 98
  http://rdf.ncbi.nlm.nih.gov/pubmed/11572983
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• J. Yu, et.al., PUMA induces the rapid apoptosis of colorectal cancer cells., Molecular cell, 2001, 7
  http://rdf.ncbi.nlm.nih.gov/pubmed/11463391
• Andreas. Villunger, et.al., p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa., Science (New York, N.Y.), 2003, 302
  http://rdf.ncbi.nlm.nih.gov/pubmed/14500851
• Decheng. Ren, et.al., BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program., Science (New York, N.Y.), 2010, 330
  http://rdf.ncbi.nlm.nih.gov/pubmed/21127253

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• cellular response to ionizing radiation
  http://purl.obolibrary.org/obo/GO_0071479
• negative regulation of growth
  http://purl.obolibrary.org/obo/GO_0045926
• negative regulation of cell growth
  http://purl.obolibrary.org/obo/GO_0030308
• cytosol
  http://purl.obolibrary.org/obo/GO_0005829
• positive regulation of release of cytochrome c from mitochondria
  http://purl.obolibrary.org/obo/GO_0090200
• determination of adult lifespan
  http://purl.obolibrary.org/obo/GO_0008340
• release of cytochrome c from mitochondria
  http://purl.obolibrary.org/obo/GO_0001836
• positive regulation of thymocyte apoptotic process
  http://purl.obolibrary.org/obo/GO_0070245
• activation of cysteine-type endopeptidase activity
  http://purl.obolibrary.org/obo/GO_0097202
• mitochondrion
  http://purl.obolibrary.org/obo/GO_0005739
• intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
  http://purl.obolibrary.org/obo/GO_0042771
• positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
  http://purl.obolibrary.org/obo/GO_0043280
• negative regulation of endoplasmic reticulum calcium ion concentration
  http://purl.obolibrary.org/obo/GO_0032471
• BH domain binding
  http://purl.obolibrary.org/obo/GO_0051400
• protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
  http://purl.obolibrary.org/obo/GO_0001844
• protein binding
  http://purl.obolibrary.org/obo/GO_0005515
• positive regulation of apoptotic process
  http://purl.obolibrary.org/obo/GO_0043065
• mitochondrial envelope
  http://purl.obolibrary.org/obo/GO_0005740
• apoptotic process
  http://purl.obolibrary.org/obo/GO_0006915
• positive regulation of protein homooligomerization
  http://purl.obolibrary.org/obo/GO_0032464
• activation of cysteine-type endopeptidase activity involved in apoptotic process
  http://purl.obolibrary.org/obo/GO_0006919
• release of sequestered calcium ion into cytosol
  http://purl.obolibrary.org/obo/GO_0051209
• membrane
  http://purl.obolibrary.org/obo/GO_0016020
• intracellular
  http://purl.obolibrary.org/obo/GO_0005622

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map04115
• http://www.genome.jp/dbget-bin/www_bget?map05162
• http://www.genome.jp/dbget-bin/www_bget?map05016

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• p53 signaling pathway
• Huntington's disease
• Measles