CD06640

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD06640

CD06640

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Akt2

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• thymoma viral proto-oncogene 2

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• RAC-PK-beta
• RAC-beta serine/threonine protein kinase
• PKB beta
• protein kinase B beta
• protein kinase B, beta
• RAC-beta serine/threonine-protein kinase
• thymoma viral proto-oncogene 2
• protein kinase Akt-2

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• PKBbeta
• AW554154
• 2410016A19Rik
• PKB

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/11652

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• thymoma viral proto-oncogene 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:104874

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_007434
• https://www.ncbi.nlm.nih.gov/nuccore/NM_001110208

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000004056

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.177194

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=164731

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• D A. Altomare, et.al., Cloning, chromosomal localization and expression analysis of the mouse Akt2 oncogene., Oncogene, 1995, 11
  http://rdf.ncbi.nlm.nih.gov/pubmed/7566964
• D A. Altomare, et.al., Chromosome mapping of the mouse Akt2 gene and Akt2 pseudogene., Cytogenetics and cell genetics, 1996, 74
  http://rdf.ncbi.nlm.nih.gov/pubmed/8976376
• Zai. Chang, et.al., Deletion of Akt1 causes heart defects and abnormal cardiomyocyte proliferation., Developmental biology, 2010, 347
  http://rdf.ncbi.nlm.nih.gov/pubmed/20816796
• Andrew N. Macintyre, et.al., Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism., Immunity, 2011, 34
  http://rdf.ncbi.nlm.nih.gov/pubmed/21295499
• D A. Altomare, et.al., Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2 kinase is activated by insulin., Oncogene, 1998, 16
  http://rdf.ncbi.nlm.nih.gov/pubmed/9620559
• Vivian A. Galicia, et.al., Expansion of hepatic tumor progenitor cells in Pten-null mice requires liver injury and is reversed by loss of AKT2., Gastroenterology, 2010, 139
  http://rdf.ncbi.nlm.nih.gov/pubmed/20837017
• S R. Datta, et.al., Cellular survival: a play in three Akts., Genes & development, 1999, 13
  http://rdf.ncbi.nlm.nih.gov/pubmed/10579998
• Marcus D. Goncalves, et.al., Akt deficiency attenuates muscle size and function but not the response to ActRIIB inhibition., PloS one, 2010, 5
  http://rdf.ncbi.nlm.nih.gov/pubmed/20856813
• S P. Staal, Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma., Proceedings of the National Academy of Sciences of the United States of America, 1987, 84
  http://rdf.ncbi.nlm.nih.gov/pubmed/3037531

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• plasma membrane
  http://purl.obolibrary.org/obo/GO_0005886
• carbohydrate metabolic process
  http://purl.obolibrary.org/obo/GO_0005975
• soluble fraction
  http://purl.obolibrary.org/obo/GO_0005625
• cytosol
  http://purl.obolibrary.org/obo/GO_0005829
• positive regulation of signal transduction
  http://purl.obolibrary.org/obo/GO_0009967
• positive regulation of transcription from RNA polymerase II promoter
  http://purl.obolibrary.org/obo/GO_0045944
• glucose metabolic process
  http://purl.obolibrary.org/obo/GO_0006006
• protein serine/threonine kinase activity
  http://purl.obolibrary.org/obo/GO_0004674
• lamellipodium
  http://purl.obolibrary.org/obo/GO_0030027
• positive regulation of cell migration
  http://purl.obolibrary.org/obo/GO_0030335
• positive regulation of glycogen biosynthetic process
  http://purl.obolibrary.org/obo/GO_0045725
• carbohydrate transport
  http://purl.obolibrary.org/obo/GO_0008643
• positive regulation of glucose import
  http://purl.obolibrary.org/obo/GO_0046326
• regulation of translation
  http://purl.obolibrary.org/obo/GO_0006417
• transport
  http://purl.obolibrary.org/obo/GO_0006810
• protein kinase C binding
  http://purl.obolibrary.org/obo/GO_0005080
• kinase activity
  http://purl.obolibrary.org/obo/GO_0016301
• protein binding
  http://purl.obolibrary.org/obo/GO_0005515
• nucleus
  http://purl.obolibrary.org/obo/GO_0005634
• positive regulation of sodium ion transport
  http://purl.obolibrary.org/obo/GO_0010765
• phosphorylation
  http://purl.obolibrary.org/obo/GO_0016310
• vesicle
  http://purl.obolibrary.org/obo/GO_0031982
• microsome
  http://purl.obolibrary.org/obo/GO_0005792
• transferase activity
  http://purl.obolibrary.org/obo/GO_0016740
• ATP binding
  http://purl.obolibrary.org/obo/GO_0005524
• protein kinase B signaling
  http://purl.obolibrary.org/obo/GO_0043491
• protein phosphorylation
  http://purl.obolibrary.org/obo/GO_0006468
• protein kinase activity
  http://purl.obolibrary.org/obo/GO_0004672
• insulin receptor signaling pathway
  http://purl.obolibrary.org/obo/GO_0008286
• transferase activity, transferring phosphorus-containing groups
  http://purl.obolibrary.org/obo/GO_0016772
• mitochondrion
  http://purl.obolibrary.org/obo/GO_0005739
• glycogen metabolic process
  http://purl.obolibrary.org/obo/GO_0005977
• positive regulation of peptidyl-serine phosphorylation
  http://purl.obolibrary.org/obo/GO_0033138
• apoptotic process
  http://purl.obolibrary.org/obo/GO_0006915
• positive regulation of protein phosphorylation
  http://purl.obolibrary.org/obo/GO_0001934
• positive regulation of nitric oxide biosynthetic process
  http://purl.obolibrary.org/obo/GO_0045429
• negative regulation of RNA splicing
  http://purl.obolibrary.org/obo/GO_0033119
• cytoplasm
  http://purl.obolibrary.org/obo/GO_0005737
• positive regulation of cell motility
  http://purl.obolibrary.org/obo/GO_2000147
• insulin-responsive compartment
  http://purl.obolibrary.org/obo/GO_0032593
• nucleotide binding
  http://purl.obolibrary.org/obo/GO_0000166
• regulation of JNK cascade
  http://purl.obolibrary.org/obo/GO_0046328
• membrane
  http://purl.obolibrary.org/obo/GO_0016020
• positive regulation of glucose metabolic process
  http://purl.obolibrary.org/obo/GO_0010907
• negative regulation of apoptotic process
  http://purl.obolibrary.org/obo/GO_0043066
• cellular response to insulin stimulus
  http://purl.obolibrary.org/obo/GO_0032869
• positive regulation of gene expression
  http://purl.obolibrary.org/obo/GO_0010628
• positive regulation of positive chemotaxis
  http://purl.obolibrary.org/obo/GO_0050927
• negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
  http://purl.obolibrary.org/obo/GO_0043154
• positive regulation of fatty acid beta-oxidation
  http://purl.obolibrary.org/obo/GO_0032000
• glycogen biosynthetic process
  http://purl.obolibrary.org/obo/GO_0005978
• negative regulation of plasma membrane long-chain fatty acid transport
  http://purl.obolibrary.org/obo/GO_0010748

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map00000

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Non-small cell lung cancer