CD06772

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD06772

CD06772

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Map3k1

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• mitogen-activated protein kinase kinase kinase 1

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• MAPK/ERK kinase kinase 1
• MEK kinase 1
• MEKK 1
• mitogen activated protein kinase kinase kinase 1
• mitogen-activated protein kinase kinase kinase 1

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• MAPKKK1
• MEKK1
• Mekk

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/26401

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• mitogen-activated protein kinase kinase kinase 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:1346872

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_011945

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000021754

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.15918

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=600982

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• Thomas. Enzler, et.al., MEKK1 binds HECT E3 ligase Itch by its amino-terminal RING motif to regulate Th2 cytokine gene expression., Journal of immunology (Baltimore, Md. : 1950), 2009, 183
  http://rdf.ncbi.nlm.nih.gov/pubmed/19710465
• Young-Ho. Ahn, et.al., MKK4/SEK1 is negatively regulated through a feedback loop involving the E3 ubiquitin ligase itch., The Journal of biological chemistry, 2009, 284
  http://rdf.ncbi.nlm.nih.gov/pubmed/19737936
• Ying-Mei. Jiang, et.al., [Fine mapping of mutant gene related corneal opacity mouse with SNPs]., Yi chuan = Hereditas, 2010, 32
  http://rdf.ncbi.nlm.nih.gov/pubmed/20466638
• M Rafiq. Islam, et.al., MAP/ERK kinase kinase 1 (MEKK1) mediates transcriptional repression by interacting with polycystic kidney disease-1 (PKD1) promoter-bound p53 tumor suppressor protein., The Journal of biological chemistry, 2010, 285
  http://rdf.ncbi.nlm.nih.gov/pubmed/20923779
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• D M. Juriloff, Prevention of the eye closure defect in lgMl/lgMl fetal mice by thyroxine., Teratology, 1985, 32
  http://rdf.ncbi.nlm.nih.gov/pubmed/4035594
他4件を見る
• K F. Stein, et.al., Further data on the slit-lid mutant in mice and the effect of cortisone and doca on its development., Teratology, 1973, 8
  http://rdf.ncbi.nlm.nih.gov/pubmed/4724491
• N S. Ricardo, et.al., Further observations on lg MI (lid-gap Miller) and other ope1-eye mutants in the house mouse., Canadian journal of genetics and cytology. Journal canadien de genetique et de cytologie, 1967, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/4865553
• K F. Stein, et.al., Development of an open eyelid mutant in mus musculus., Developmental biology, 1967, 16
  http://rdf.ncbi.nlm.nih.gov/pubmed/5630254
• M J. Harris, et.al., Cortisone cure of the lidgap defect in fetal mice: a dose-response and time-response study., Teratology, 1984, 29
  http://rdf.ncbi.nlm.nih.gov/pubmed/6740513

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• MAPK cascade
  http://purl.obolibrary.org/obo/GO_0000165
• nucleotide binding
  http://purl.obolibrary.org/obo/GO_0000166
• activation of MAPKK activity
  http://purl.obolibrary.org/obo/GO_0000186
• protein polyubiquitination
  http://purl.obolibrary.org/obo/GO_0000209
• protein kinase activity
  http://purl.obolibrary.org/obo/GO_0004672
• JUN kinase kinase kinase activity
  http://purl.obolibrary.org/obo/GO_0004706
他34件を見る
• protein binding
  http://purl.obolibrary.org/obo/GO_0005515
• ATP binding
  http://purl.obolibrary.org/obo/GO_0005524
• intracellular
  http://purl.obolibrary.org/obo/GO_0005622
• membrane fraction
  http://purl.obolibrary.org/obo/GO_0005624
• cytoplasm
  http://purl.obolibrary.org/obo/GO_0005737
• cytoskeleton
  http://purl.obolibrary.org/obo/GO_0005856
• protein phosphorylation
  http://purl.obolibrary.org/obo/GO_0006468
• ubiquitin-dependent protein catabolic process
  http://purl.obolibrary.org/obo/GO_0006511
• response to osmotic stress
  http://purl.obolibrary.org/obo/GO_0006970
• transforming growth factor beta receptor signaling pathway
  http://purl.obolibrary.org/obo/GO_0007179
• JNK cascade
  http://purl.obolibrary.org/obo/GO_0007254
• activation of JNKK activity
  http://purl.obolibrary.org/obo/GO_0007256
• activation of JUN kinase activity
  http://purl.obolibrary.org/obo/GO_0007257
• JUN kinase binding
  http://purl.obolibrary.org/obo/GO_0008432
• JUN kinase kinase activity
  http://purl.obolibrary.org/obo/GO_0008545
• apoptotic mitochondrial changes
  http://purl.obolibrary.org/obo/GO_0008637
• peptidyl-serine phosphorylation
  http://purl.obolibrary.org/obo/GO_0018105
• protein kinase binding
  http://purl.obolibrary.org/obo/GO_0019901
• regulation of cell migration
  http://purl.obolibrary.org/obo/GO_0030334
• positive regulation of actin filament polymerization
  http://purl.obolibrary.org/obo/GO_0030838
• mitogen-activated protein kinase kinase binding
  http://purl.obolibrary.org/obo/GO_0031434
• negative regulation of actin filament bundle assembly
  http://purl.obolibrary.org/obo/GO_0032232
• wound healing
  http://purl.obolibrary.org/obo/GO_0042060
• camera-type eye development
  http://purl.obolibrary.org/obo/GO_0043010
• positive regulation of apoptotic process
  http://purl.obolibrary.org/obo/GO_0043065
• positive regulation of MAP kinase activity
  http://purl.obolibrary.org/obo/GO_0043406
• positive regulation of JUN kinase activity
  http://purl.obolibrary.org/obo/GO_0043507
• positive regulation of transcription from RNA polymerase II promoter
  http://purl.obolibrary.org/obo/GO_0045944
• sphingolipid binding
  http://purl.obolibrary.org/obo/GO_0046625
• protein autophosphorylation
  http://purl.obolibrary.org/obo/GO_0046777
• metal ion binding
  http://purl.obolibrary.org/obo/GO_0046872
• positive regulation of viral transcription
  http://purl.obolibrary.org/obo/GO_0050434
• mitogen-activated protein kinase binding
  http://purl.obolibrary.org/obo/GO_0051019
• protein oligomerization
  http://purl.obolibrary.org/obo/GO_0051259

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map04010
• http://www.genome.jp/dbget-bin/www_bget?map04120
• http://www.genome.jp/dbget-bin/www_bget?map04622
• http://www.genome.jp/dbget-bin/www_bget?map04722
• http://www.genome.jp/dbget-bin/www_bget?map04912
• http://www.genome.jp/dbget-bin/www_bget?map05166

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• GnRH signaling pathway
• HTLV-I infection
• MAPK signaling pathway
• Neurotrophin signaling pathway
• RIG-I-like receptor signaling pathway
• Ubiquitin mediated proteolysis