CD06856

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD06856

CD06856

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Shmt1

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• serine hydroxymethyltransferase 1 (soluble)

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• serine methylase
• serine hydroxymethyltransferase, cytosolic
• serine hydroxymethyltransferase 1 (soluble)
• glycine hydroxymethyltransferase

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• AI324848
• mshmt1
• mshmt
• Shmt
• mshmt2
• AI385541
• C81125

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/20425

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• serine hydroxymethyltransferase 1 (soluble)
  http://metadb.riken.jp/db/mgi_rdf/MGI:98299

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_009171

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000020534

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.364956

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=182144

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• D M. Szebenyi, et.al., Structure of a murine cytoplasmic serine hydroxymethyltransferase quinonoid ternary complex: evidence for asymmetric obligate dimers., Biochemistry, 2000, 39
  http://rdf.ncbi.nlm.nih.gov/pubmed/11063567
• Jason A. Hackney, et.al., A molecular profile of a hematopoietic stem cell niche., Proceedings of the National Academy of Sciences of the United States of America, 2002, 99
  http://rdf.ncbi.nlm.nih.gov/pubmed/12226475
• Y. Piao, et.al., Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method., Genome research, 2001, 11
  http://rdf.ncbi.nlm.nih.gov/pubmed/11544199
• F J. Probst, et.al., A physical map of the mouse shaker-2 region contains many of the genes commonly deleted in Smith-Magenis syndrome (del17p11.2p11.2)., Genomics, 1999, 55
  http://rdf.ncbi.nlm.nih.gov/pubmed/10049592
• H. Nakshatri, et.al., Isolation of retinoic acid-repressed genes from P19 embryonal carcinoma cells., Gene, 1996, 174
  http://rdf.ncbi.nlm.nih.gov/pubmed/8863732
• Takeo. Yoshikawa, et.al., [Analysis of mouse strain-dependent prepulse inhibition points to a role for Shmt1 (SHMT1) in mice and in schizophrenia]., Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 2010, 30
  http://rdf.ncbi.nlm.nih.gov/pubmed/21226315
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• Donald D. Anderson, et.al., SHMT1 and SHMT2 are functionally redundant in nuclear de novo thymidylate biosynthesis., PloS one, 2009, 4
  http://rdf.ncbi.nlm.nih.gov/pubmed/19513116
• Amanda J. MacFarlane, et.al., Cytoplasmic serine hydroxymethyltransferase regulates the metabolic partitioning of methylenetetrahydrofolate but is not essential in mice., The Journal of biological chemistry, 2008, 283
  http://rdf.ncbi.nlm.nih.gov/pubmed/18644786
• Motoko. Maekawa, et.al., Analysis of strain-dependent prepulse inhibition points to a role for Shmt1 (SHMT1) in mice and in schizophrenia., Journal of neurochemistry, 2010, 115
  http://rdf.ncbi.nlm.nih.gov/pubmed/20977478

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• identical protein binding
  http://purl.obolibrary.org/obo/GO_0042802
• glycine hydroxymethyltransferase activity
  http://purl.obolibrary.org/obo/GO_0004372
• cytosol
  http://purl.obolibrary.org/obo/GO_0005829
• L-allo-threonine aldolase activity
  http://purl.obolibrary.org/obo/GO_0008732
• folic acid metabolic process
  http://purl.obolibrary.org/obo/GO_0046655
• catalytic activity
  http://purl.obolibrary.org/obo/GO_0003824
• glycine biosynthetic process from serine
  http://purl.obolibrary.org/obo/GO_0019264
• protein homotetramerization
  http://purl.obolibrary.org/obo/GO_0051289
• mitochondrion
  http://purl.obolibrary.org/obo/GO_0005739
• protein homodimerization activity
  http://purl.obolibrary.org/obo/GO_0042803
• purine nucleobase biosynthetic process
  http://purl.obolibrary.org/obo/GO_0009113
• nucleus
  http://purl.obolibrary.org/obo/GO_0005634
• L-serine metabolic process
  http://purl.obolibrary.org/obo/GO_0006563
• pyridoxal phosphate binding
  http://purl.obolibrary.org/obo/GO_0030170
• amino acid binding
  http://purl.obolibrary.org/obo/GO_0016597
• one-carbon metabolic process
  http://purl.obolibrary.org/obo/GO_0006730
• glycine biosynthetic process
  http://purl.obolibrary.org/obo/GO_0006545
• glycine metabolic process
  http://purl.obolibrary.org/obo/GO_0006544
• L-serine catabolic process
  http://purl.obolibrary.org/obo/GO_0006565
• protein tetramerization
  http://purl.obolibrary.org/obo/GO_0051262
• transferase activity
  http://purl.obolibrary.org/obo/GO_0016740
• cytoplasm
  http://purl.obolibrary.org/obo/GO_0005737

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map00460
• http://www.genome.jp/dbget-bin/www_bget?map00670
• http://www.genome.jp/dbget-bin/www_bget?map01100
• http://www.genome.jp/dbget-bin/www_bget?map00260

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Glycine
• One carbon pool by folate
• Cyanoamino acid metabolism
• Metabolic pathways
• serine and threonine metabolism