CD06910

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD06910

CD06910

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Lck

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• lymphocyte protein tyrosine kinase

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• lymphocyte cell-specific protein-tyrosine kinase
• proto-oncogene tyrosine-protein kinase LCK
• leukocyte C-terminal Src kinase
• lymphocyte protein tyrosine kinase

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• p56<lck>
• Hck-3
• p56Lck
• Lsk
• Lskt

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/16818

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• lymphocyte protein tyrosine kinase
  http://metadb.riken.jp/db/mgi_rdf/MGI:96756

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_001162432
• https://www.ncbi.nlm.nih.gov/nuccore/NM_010693
• https://www.ncbi.nlm.nih.gov/nuccore/NM_001162433

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000000409

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.293753

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=153390

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• Renee M. Laird, et.al., Unexpected role for the B cell-specific Src family kinase B lymphoid kinase in the development of IL-17-producing γδ T cells., Journal of immunology (Baltimore, Md. : 1950), 2010, 185
  http://rdf.ncbi.nlm.nih.gov/pubmed/20974990
• D R. Beier, et.al., Mapping genes in the mouse using single-strand conformation polymorphism analysis of recombinant inbred strains and interspecific crosses., Proceedings of the National Academy of Sciences of the United States of America, 1992, 89
  http://rdf.ncbi.nlm.nih.gov/pubmed/1409609
• J A. Haefliger, et.al., Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mapping., The Journal of biological chemistry, 1992, 267
  http://rdf.ncbi.nlm.nih.gov/pubmed/1370487
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• T R. Hurley, et.al., Creation and characterization of temperature-sensitive mutants of the lck tyrosine protein kinase., Journal of virology, 1992, 66
  http://rdf.ncbi.nlm.nih.gov/pubmed/1279202
• Stefano. Caserta, et.al., Reduced functional avidity promotes central and effector memory CD4 T cell responses to tumor-associated antigens., Journal of immunology (Baltimore, Md. : 1950), 2010, 185
  http://rdf.ncbi.nlm.nih.gov/pubmed/21048115
• Kyeorda L. Kemp, et.al., Lck regulates IL-10 expression in memory-like Th1 cells., European journal of immunology, 2010, 40
  http://rdf.ncbi.nlm.nih.gov/pubmed/21061443
• Robert J. Salmond, et.al., Mislocalization of Lck impairs thymocyte differentiation and can promote development of thymomas., Blood, 2011, 117
  http://rdf.ncbi.nlm.nih.gov/pubmed/20876849
• D B. Straus, et.al., Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor., Cell, 1992, 70
  http://rdf.ncbi.nlm.nih.gov/pubmed/1505025
• T. Mori, et.al., Expression of the signal transducing regions of CD4-like and lck genes in murine egg., Biochemical and biophysical research communications, 1992, 182
  http://rdf.ncbi.nlm.nih.gov/pubmed/1370884

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• activation of cysteine-type endopeptidase activity involved in apoptotic process
  http://purl.obolibrary.org/obo/GO_0006919
• cell surface receptor signaling pathway
  http://purl.obolibrary.org/obo/GO_0007166
• response to metal ion
  http://purl.obolibrary.org/obo/GO_0010038
• endocytic vesicle
  http://purl.obolibrary.org/obo/GO_0030139
• positive regulation of uterine smooth muscle contraction
  http://purl.obolibrary.org/obo/GO_0070474
• protein phosphorylation
  http://purl.obolibrary.org/obo/GO_0006468
• activation of cysteine-type endopeptidase activity
  http://purl.obolibrary.org/obo/GO_0097202
• nucleotide binding
  http://purl.obolibrary.org/obo/GO_0000166
• protein binding
  http://purl.obolibrary.org/obo/GO_0005515
• response to mechanical stimulus
  http://purl.obolibrary.org/obo/GO_0009612
• protein kinase binding
  http://purl.obolibrary.org/obo/GO_0019901
• ATP binding
  http://purl.obolibrary.org/obo/GO_0005524
• membrane raft
  http://purl.obolibrary.org/obo/GO_0045121
• membrane
  http://purl.obolibrary.org/obo/GO_0016020
• protein C-terminus binding
  http://purl.obolibrary.org/obo/GO_0008022
• cytoplasm
  http://purl.obolibrary.org/obo/GO_0005737
• peptidyl-tyrosine phosphorylation
  http://purl.obolibrary.org/obo/GO_0018108
• B cell receptor signaling pathway
  http://purl.obolibrary.org/obo/GO_0050853
• pericentriolar material
  http://purl.obolibrary.org/obo/GO_0000242
• positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
  http://purl.obolibrary.org/obo/GO_0043280
• positive regulation of tyrosine phosphorylation of STAT protein
  http://purl.obolibrary.org/obo/GO_0042531
• transferase activity, transferring phosphorus-containing groups
  http://purl.obolibrary.org/obo/GO_0016772
• SH2 domain binding
  http://purl.obolibrary.org/obo/GO_0042169
• plasma membrane
  http://purl.obolibrary.org/obo/GO_0005886
• positive regulation of T cell activation
  http://purl.obolibrary.org/obo/GO_0050870
• cytosol
  http://purl.obolibrary.org/obo/GO_0005829
• Golgi apparatus
  http://purl.obolibrary.org/obo/GO_0005794
• protein tyrosine kinase activity
  http://purl.obolibrary.org/obo/GO_0004713
• ATPase binding
  http://purl.obolibrary.org/obo/GO_0051117
• response to drug
  http://purl.obolibrary.org/obo/GO_0042493
• protein serine/threonine phosphatase activity
  http://purl.obolibrary.org/obo/GO_0004722
• phosphorylation
  http://purl.obolibrary.org/obo/GO_0016310
• CD8 receptor binding
  http://purl.obolibrary.org/obo/GO_0042610
• protein autophosphorylation
  http://purl.obolibrary.org/obo/GO_0046777
• kinase activity
  http://purl.obolibrary.org/obo/GO_0016301
• dephosphorylation
  http://purl.obolibrary.org/obo/GO_0016311
• regulation of T cell receptor signaling pathway
  http://purl.obolibrary.org/obo/GO_0050856
• CD4 receptor binding
  http://purl.obolibrary.org/obo/GO_0042609
• positive regulation of gene expression
  http://purl.obolibrary.org/obo/GO_0010628
• antigen binding
  http://purl.obolibrary.org/obo/GO_0003823
• release of sequestered calcium ion into cytosol
  http://purl.obolibrary.org/obo/GO_0051209
• response to hydrogen peroxide
  http://purl.obolibrary.org/obo/GO_0042542
• non-membrane spanning protein tyrosine kinase activity
  http://purl.obolibrary.org/obo/GO_0004715
• apoptotic process
  http://purl.obolibrary.org/obo/GO_0006915
• phosphatidylinositol 3-kinase binding
  http://purl.obolibrary.org/obo/GO_0043548
• positive regulation of gamma-delta T cell differentiation
  http://purl.obolibrary.org/obo/GO_0045588
• macromolecular complex binding
  http://purl.obolibrary.org/obo/GO_0044877
• transferase activity
  http://purl.obolibrary.org/obo/GO_0016740
• T cell differentiation
  http://purl.obolibrary.org/obo/GO_0030217
• protein kinase activity
  http://purl.obolibrary.org/obo/GO_0004672

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map04380
• http://www.genome.jp/dbget-bin/www_bget?map05166
• http://www.genome.jp/dbget-bin/www_bget?map04660
• http://www.genome.jp/dbget-bin/www_bget?map04650
• http://www.genome.jp/dbget-bin/www_bget?map05340

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Osteoclast differentiation
• Primary immunodeficiency
• Natural killer cell mediated cytotoxicity
• HTLV-I infection
• T cell receptor signaling pathway