CD07624

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD07624

CD07624

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Ppp3cb

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• protein phosphatase 3, catalytic subunit, beta isoform

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• calmodulin-dependent calcineurin A subunit beta isoform
• CAM-PRP catalytic subunit
• protein phosphatase 3, catalytic subunit, beta isoform
• serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• PP2BA beta
• Cnab
• Calnb
• CnAbeta
• 1110063J16Rik

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/19056

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• protein phosphatase 3, catalytic subunit, beta isoform
  http://metadb.riken.jp/db/mgi_rdf/MGI:107163

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_008914

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000021816

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.274432
• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.474197

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=114106

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• P R. Giri, et.al., Chromosomal mapping of the human genes for the calmodulin-dependent protein phosphatase (calcineurin) catalytic subunit., Biochemical and biophysical research communications, 1991, 181
  http://rdf.ncbi.nlm.nih.gov/pubmed/1659808
• R L. Kincaid, et.al., Cloning and characterization of molecular isoforms of the catalytic subunit of calcineurin using nonisotopic methods., The Journal of biological chemistry, 1990, 265
  http://rdf.ncbi.nlm.nih.gov/pubmed/2162844
• P R. Giri, et.al., Molecular and phylogenetic analysis of calmodulin-dependent protein phosphatase (calcineurin) catalytic subunit genes., DNA and cell biology, 1992, 11
  http://rdf.ncbi.nlm.nih.gov/pubmed/1318721
• K. Ueki, et.al., Structure and expression of two isoforms of the murine calmodulin-dependent protein phosphatase regulatory subunit (calcineurin B)., Biochemical and biophysical research communications, 1992, 187
  http://rdf.ncbi.nlm.nih.gov/pubmed/1325794
• Tiffany K. Roberts-Wilson, et.al., Calcineurin signaling and PGC-1alpha expression are suppressed during muscle atrophy due to diabetes., Biochimica et biophysica acta, 2010, 1803
  http://rdf.ncbi.nlm.nih.gov/pubmed/20359506
• M. Gaestel, et.al., Dephosphorylation of the small heat shock protein hsp25 by calcium/calmodulin-dependent (type 2B) protein phosphatase., The Journal of biological chemistry, 1992, 267
  http://rdf.ncbi.nlm.nih.gov/pubmed/1328240
• Tao. Sun, et.al., The role of calcium/calmodulin-activated calcineurin in rapid and slow endocytosis at central synapses., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, 30
  http://rdf.ncbi.nlm.nih.gov/pubmed/20810903
• Thomas. Doetschman, et.al., Divergent effects of calcineurin Aβ on regulatory and conventional T-cell homeostasis., Clinical immunology (Orlando, Fla.), 2011, 138
  http://rdf.ncbi.nlm.nih.gov/pubmed/21256088
• Joerg. Heineke, et.al., CIB1 is a regulator of pathological cardiac hypertrophy., Nature medicine, 2010, 16
  http://rdf.ncbi.nlm.nih.gov/pubmed/20639889
• Hong. Zhu, et.al., Evolutionarily conserved role of calcineurin in phosphodegron-dependent degradation of phosphodiesterase 4D., Molecular and cellular biology, 2010, 30
  http://rdf.ncbi.nlm.nih.gov/pubmed/20647544

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• metabolic process
  http://purl.obolibrary.org/obo/GO_0008152
• T cell differentiation
  http://purl.obolibrary.org/obo/GO_0030217
• heart development
  http://purl.obolibrary.org/obo/GO_0007507
• insoluble fraction
  http://purl.obolibrary.org/obo/GO_0005626
• regulation of gene expression
  http://purl.obolibrary.org/obo/GO_0010468
• macromolecular complex
  http://purl.obolibrary.org/obo/GO_0032991
• protein dephosphorylation
  http://purl.obolibrary.org/obo/GO_0006470
• phosphoprotein phosphatase activity
  http://purl.obolibrary.org/obo/GO_0004721
• calmodulin binding
  http://purl.obolibrary.org/obo/GO_0005516
• hydrolase activity
  http://purl.obolibrary.org/obo/GO_0016787
• dephosphorylation
  http://purl.obolibrary.org/obo/GO_0016311
• T cell homeostasis
  http://purl.obolibrary.org/obo/GO_0043029
• protein serine/threonine phosphatase activity
  http://purl.obolibrary.org/obo/GO_0004722
• response to cytokine
  http://purl.obolibrary.org/obo/GO_0034097
• soluble fraction
  http://purl.obolibrary.org/obo/GO_0005625
• negative regulation of T cell mediated cytotoxicity
  http://purl.obolibrary.org/obo/GO_0001915
• calcium-dependent protein serine/threonine phosphatase activity
  http://purl.obolibrary.org/obo/GO_0004723
• metal ion binding
  http://purl.obolibrary.org/obo/GO_0046872
• protein heterodimerization activity
  http://purl.obolibrary.org/obo/GO_0046982

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map04370
• http://www.genome.jp/dbget-bin/www_bget?map04114
• http://www.genome.jp/dbget-bin/www_bget?map04380
• http://www.genome.jp/dbget-bin/www_bget?map05152
• http://www.genome.jp/dbget-bin/www_bget?map04360
• http://www.genome.jp/dbget-bin/www_bget?map05014
• http://www.genome.jp/dbget-bin/www_bget?map05166
• http://www.genome.jp/dbget-bin/www_bget?map04720
• http://www.genome.jp/dbget-bin/www_bget?map04724
• http://www.genome.jp/dbget-bin/www_bget?map04310
• http://www.genome.jp/dbget-bin/www_bget?map04650
• http://www.genome.jp/dbget-bin/www_bget?map04662
• http://www.genome.jp/dbget-bin/www_bget?map04010
• http://www.genome.jp/dbget-bin/www_bget?map04728
• http://www.genome.jp/dbget-bin/www_bget?map04660
• http://www.genome.jp/dbget-bin/www_bget?map04210
• http://www.genome.jp/dbget-bin/www_bget?map05010
• http://www.genome.jp/dbget-bin/www_bget?map04020

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• T cell receptor signaling pathway
• B cell receptor signaling pathway
• Axon guidance
• VEGF signaling pathway
• Osteoclast differentiation
• Calcium signaling pathway
• Tuberculosis
• HTLV-I infection
• Oocyte meiosis
• Long-term potentiation
• Alzheimer's disease
• MAPK signaling pathway
• Dopaminergic synapse
• Apoptosis
• Amyotrophic lateral sclerosis (ALS)
• Natural killer cell mediated cytotoxicity
• Glutamatergic synapse
• Wnt signaling pathway