CD11906

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD11906

CD11906

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Wfs1

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• Wolfram syndrome 1 homolog (human)

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• Wolfram syndrome 1 protein homolog
• Wolfram syndrome 1 homolog (human)

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• wolframin
• AI481085

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/22393

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• wolframin ER transmembrane glycoprotein
  http://metadb.riken.jp/db/mgi_rdf/MGI:1328355

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_011716

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000039474

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.20916

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=606201

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• Kim. Cryns, et.al., The WFS1 gene, responsible for low frequency sensorineural hearing loss and Wolfram syndrome, is expressed in a variety of inner ear cells., Histochemistry and cell biology, 2003, 119
  http://rdf.ncbi.nlm.nih.gov/pubmed/12649740
• Klari. Noormets, et.al., Male mice with deleted Wolframin (Wfs1) gene have reduced fertility., Reproductive biology and endocrinology : RB&E, 2009, 7
  http://rdf.ncbi.nlm.nih.gov/pubmed/19664290
• Sonya G. Fonseca, et.al., Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells., The Journal of clinical investigation, 2010, 120
  http://rdf.ncbi.nlm.nih.gov/pubmed/20160352
• H. Inoue, et.al., A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome)., Nature genetics, 1998, 20
  http://rdf.ncbi.nlm.nih.gov/pubmed/9771706
• Hisamitsu. Ishihara, et.al., Disruption of the WFS1 gene in mice causes progressive beta-cell loss and impaired stimulus-secretion coupling in insulin secretion., Human molecular genetics, 2004, 13
  http://rdf.ncbi.nlm.nih.gov/pubmed/15056606
• B. Hurle, et.al., Physical mapping of the mouse tilted locus identifies an association between human deafness loci DFNA6/14 and vestibular system development., Genomics, 2001, 77
  http://rdf.ncbi.nlm.nih.gov/pubmed/11597144
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• T M. Strom, et.al., Diabetes insipidus, diabetes mellitus, optic atrophy and deafness (DIDMOAD) caused by mutations in a novel gene (wolframin) coding for a predicted transmembrane protein., Human molecular genetics, 1998, 7
  http://rdf.ncbi.nlm.nih.gov/pubmed/9817917
• Masayuki. Hatanaka, et.al., Wolfram syndrome 1 gene (WFS1) product localizes to secretory granules and determines granule acidification in pancreatic beta-cells., Human molecular genetics, 2011, 20
  http://rdf.ncbi.nlm.nih.gov/pubmed/21199859
• Pablo J. Fernandez-Marcos, et.al., Normal proliferation and tumorigenesis but impaired pancreatic function in mice lacking the cell cycle regulator sei1., PloS one, 2010, 5
  http://rdf.ncbi.nlm.nih.gov/pubmed/20090907

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• glucose homeostasis
  http://purl.obolibrary.org/obo/GO_0042593
• ubiquitin protein ligase binding
  http://purl.obolibrary.org/obo/GO_0031625
• protein stabilization
  http://purl.obolibrary.org/obo/GO_0050821
• activating transcription factor binding
  http://purl.obolibrary.org/obo/GO_0033613
• neurological system process
  http://purl.obolibrary.org/obo/GO_0050877
• polyubiquitinated misfolded protein transport
  http://purl.obolibrary.org/obo/GO_0070845
• negative regulation of programmed cell death
  http://purl.obolibrary.org/obo/GO_0043069
• endoplasmic reticulum calcium ion homeostasis
  http://purl.obolibrary.org/obo/GO_0032469
• endoplasmic reticulum unfolded protein response
  http://purl.obolibrary.org/obo/GO_0030968
• positive regulation of calcium ion transport
  http://purl.obolibrary.org/obo/GO_0051928
• negative regulation of sequence-specific DNA binding transcription factor activity
  http://purl.obolibrary.org/obo/GO_0043433
• visual perception
  http://purl.obolibrary.org/obo/GO_0007601
• regulation of cell cycle
  http://purl.obolibrary.org/obo/GO_0051726
• kidney development
  http://purl.obolibrary.org/obo/GO_0001822
• positive regulation of proteolysis
  http://purl.obolibrary.org/obo/GO_0045862
• negative regulation of neuron apoptotic process
  http://purl.obolibrary.org/obo/GO_0043524
• negative regulation of apoptotic process
  http://purl.obolibrary.org/obo/GO_0043066
• integral component of endoplasmic reticulum membrane
  http://purl.obolibrary.org/obo/GO_0030176
• ATPase binding
  http://purl.obolibrary.org/obo/GO_0051117
• positive regulation of protein ubiquitination
  http://purl.obolibrary.org/obo/GO_0031398
• endoplasmic reticulum
  http://purl.obolibrary.org/obo/GO_0005783
• response to endoplasmic reticulum stress
  http://purl.obolibrary.org/obo/GO_0034976
• integral component of membrane
  http://purl.obolibrary.org/obo/GO_0016021
• transporter activity
  http://purl.obolibrary.org/obo/GO_0005215
• calcium ion homeostasis
  http://purl.obolibrary.org/obo/GO_0055074
• membrane
  http://purl.obolibrary.org/obo/GO_0016020
• renal water homeostasis
  http://purl.obolibrary.org/obo/GO_0003091
• regulation of apoptotic process
  http://purl.obolibrary.org/obo/GO_0042981
• positive regulation of protein metabolic process
  http://purl.obolibrary.org/obo/GO_0051247
• positive regulation of growth
  http://purl.obolibrary.org/obo/GO_0045927
• sensory perception of sound
  http://purl.obolibrary.org/obo/GO_0007605

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map04141

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Protein processing in endoplasmic reticulum