CD11995

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD11995

CD11995

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Smpd1

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• sphingomyelin phosphodiesterase 1, acid lysosomal

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• sphingomyelin phosphodiesterase
• sphingomyelin phosphodiesterase 1, acid lysosomal

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• Zn-SMase
• ASM
• acid sphingomyelinase
• A-SMase
• aSMase

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/20597

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• sphingomyelin phosphodiesterase 1, acid lysosomal
  http://metadb.riken.jp/db/mgi_rdf/MGI:98325

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_011421

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000037049

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.4628
• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.485064

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=607608

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• Glyn. Dawson, et.al., Gilenya (FTY720) inhibits acid sphingomyelinase by a mechanism similar to tricyclic antidepressants., Biochemical and biophysical research communications, 2011, 404
  http://rdf.ncbi.nlm.nih.gov/pubmed/21130737
• Rajwinder. Dhami, et.al., Acid sphingomyelinase deficiency attenuates bleomycin-induced lung inflammation and fibrosis in mice., Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2010, 26
  http://rdf.ncbi.nlm.nih.gov/pubmed/21063112
• K. Horinouchi, et.al., Acid sphingomyelinase deficient mice: a model of types A and B Niemann-Pick disease., Nature genetics, 1995, 10
  http://rdf.ncbi.nlm.nih.gov/pubmed/7670466
• Mónica. García-Barros, et.al., Impact of stromal sensitivity on radiation response of tumors implanted in SCID hosts revisited., Cancer research, 2010, 70
  http://rdf.ncbi.nlm.nih.gov/pubmed/20924105
• D. Newrzella, et.al., Molecular cloning of the acid sphingomyelinase of the mouse and the organization and complete nucleotide sequence of the gene., Biological chemistry Hoppe-Seyler, 1992, 373
  http://rdf.ncbi.nlm.nih.gov/pubmed/1292508
• Katrin Anne. Becker, et.al., Accumulation of ceramide in the trachea and intestine of cystic fibrosis mice causes inflammation and cell death., Biochemical and biophysical research communications, 2010, 403
  http://rdf.ncbi.nlm.nih.gov/pubmed/21078296
• P G. Pentchev, et.al., A lysosomal storage disorder in mice characterized by a dual deficiency of sphingomyelinase and glucocerebrosidase., Biochimica et biophysica acta, 1980, 619
  http://rdf.ncbi.nlm.nih.gov/pubmed/6257302
• B. Otterbach, et.al., Acid sphingomyelinase-deficient mice mimic the neurovisceral form of human lysosomal storage disease (Niemann-Pick disease)., Cell, 1995, 81
  http://rdf.ncbi.nlm.nih.gov/pubmed/7600574
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• R. Kolesnick, et.al., The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling., Cell, 1994, 77
  http://rdf.ncbi.nlm.nih.gov/pubmed/8181053

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• metabolic process
  http://purl.obolibrary.org/obo/GO_0008152
• response to cocaine
  http://purl.obolibrary.org/obo/GO_0042220
• lamellar body
  http://purl.obolibrary.org/obo/GO_0042599
• extracellular space
  http://purl.obolibrary.org/obo/GO_0005615
• ceramide biosynthetic process
  http://purl.obolibrary.org/obo/GO_0046513
• positive regulation of protein dephosphorylation
  http://purl.obolibrary.org/obo/GO_0035307
• sphingomyelin catabolic process
  http://purl.obolibrary.org/obo/GO_0006685
• lysosome
  http://purl.obolibrary.org/obo/GO_0005764
• termination of signal transduction
  http://purl.obolibrary.org/obo/GO_0023021
• hydrolase activity
  http://purl.obolibrary.org/obo/GO_0016787
• positive regulation of apoptotic process
  http://purl.obolibrary.org/obo/GO_0043065
• sphingomyelin phosphodiesterase activity
  http://purl.obolibrary.org/obo/GO_0004767
• hydrolase activity, acting on glycosyl bonds
  http://purl.obolibrary.org/obo/GO_0016798
• negative regulation of MAP kinase activity
  http://purl.obolibrary.org/obo/GO_0043407

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map04142
• http://www.genome.jp/dbget-bin/www_bget?map01100
• http://www.genome.jp/dbget-bin/www_bget?map00600

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Metabolic pathways
• Sphingolipid metabolism
• Lysosome