CD12227

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD12227

CD12227

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Grb2

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• growth factor receptor bound protein 2

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• adapter protein GRB2
• growth factor receptor bound protein 2
• growth factor receptor-bound protein 2
• SH2/SH3 adapter GRB2

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• AA408164
• Ash

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/14784

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• growth factor receptor bound protein 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:95805

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_008163

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000059923

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.439649

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=108355

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• Matthew J. Peirce, et.al., Themis2/ICB1 is a signaling scaffold that selectively regulates macrophage Toll-like receptor signaling and cytokine production., PloS one, 2010, 5
  http://rdf.ncbi.nlm.nih.gov/pubmed/20644716
• K L. Suen, et.al., Molecular cloning of the mouse grb2 gene: differential interaction of the Grb2 adaptor protein with epidermal growth factor and nerve growth factor receptors., Molecular and cellular biology, 1993, 13
  http://rdf.ncbi.nlm.nih.gov/pubmed/7689150
• B. Titz, et.al., The proximal signaling network of the BCR-ABL1 oncogene shows a modular organization., Oncogene, 2010, 29
  http://rdf.ncbi.nlm.nih.gov/pubmed/20697350
• X Y. Wang, et.al., Interleukin-11 induces complex formation of Grb2, Fyn, and JAK2 in 3T3L1 cells., The Journal of biological chemistry, 1995, 270
  http://rdf.ncbi.nlm.nih.gov/pubmed/7499280
• E J. Lowenstein, et.al., The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling., Cell, 1992, 70
  http://rdf.ncbi.nlm.nih.gov/pubmed/1322798
• L. Huang, et.al., GRB2 and SH-PTP2: potentially important endothelial signaling molecules downstream of the TEK/TIE2 receptor tyrosine kinase., Oncogene, 1995, 11
  http://rdf.ncbi.nlm.nih.gov/pubmed/7478529
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• Ihn Kyung. Jang, et.al., Grb2 functions at the top of the T-cell antigen receptor-induced tyrosine kinase cascade to control thymic selection., Proceedings of the National Academy of Sciences of the United States of America, 2010, 107
  http://rdf.ncbi.nlm.nih.gov/pubmed/20498059
• M. Rozakis-Adcock, et.al., Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases., Nature, 1992, 360
  http://rdf.ncbi.nlm.nih.gov/pubmed/1465135
• Ying. Wang, et.al., Ectopic expression of GATA6 bypasses requirement for Grb2 in primitive endoderm formation., Developmental dynamics : an official publication of the American Association of Anatomists, 2011, 240
  http://rdf.ncbi.nlm.nih.gov/pubmed/20925113

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• aging
  http://purl.obolibrary.org/obo/GO_0007568
• insulin receptor substrate binding
  http://purl.obolibrary.org/obo/GO_0043560
• phosphoprotein binding
  http://purl.obolibrary.org/obo/GO_0051219
• membrane
  http://purl.obolibrary.org/obo/GO_0016020
• receptor internalization
  http://purl.obolibrary.org/obo/GO_0031623
• fibroblast growth factor receptor signaling pathway
  http://purl.obolibrary.org/obo/GO_0008543
• SH3/SH2 adaptor activity
  http://purl.obolibrary.org/obo/GO_0005070
• cytoplasm
  http://purl.obolibrary.org/obo/GO_0005737
• vesicle membrane
  http://purl.obolibrary.org/obo/GO_0012506
• anatomical structure formation involved in morphogenesis
  http://purl.obolibrary.org/obo/GO_0048646
• nucleus
  http://purl.obolibrary.org/obo/GO_0005634
• intracellular
  http://purl.obolibrary.org/obo/GO_0005622
• phosphotyrosine binding
  http://purl.obolibrary.org/obo/GO_0001784
• protein binding
  http://purl.obolibrary.org/obo/GO_0005515
• macromolecular complex
  http://purl.obolibrary.org/obo/GO_0032991
• cell differentiation
  http://purl.obolibrary.org/obo/GO_0030154
• regulation of MAPK cascade
  http://purl.obolibrary.org/obo/GO_0043408
• cargo receptor activity
  http://purl.obolibrary.org/obo/GO_0038024
• protein heterooligomerization
  http://purl.obolibrary.org/obo/GO_0051291
• Ras protein signal transduction
  http://purl.obolibrary.org/obo/GO_0007265
• signal transduction in response to DNA damage
  http://purl.obolibrary.org/obo/GO_0042770
• ephrin receptor binding
  http://purl.obolibrary.org/obo/GO_0046875
• positive regulation of signal transduction
  http://purl.obolibrary.org/obo/GO_0009967
• Golgi apparatus
  http://purl.obolibrary.org/obo/GO_0005794
• neurotrophin TRKA receptor binding
  http://purl.obolibrary.org/obo/GO_0005168
• epidermal growth factor receptor binding
  http://purl.obolibrary.org/obo/GO_0005154
• insulin receptor signaling pathway
  http://purl.obolibrary.org/obo/GO_0008286
• positive regulation of reactive oxygen species metabolic process
  http://purl.obolibrary.org/obo/GO_2000379
• signaling receptor activity
  http://purl.obolibrary.org/obo/GO_0038023
• cellular response to ionizing radiation
  http://purl.obolibrary.org/obo/GO_0071479
• protein domain specific binding
  http://purl.obolibrary.org/obo/GO_0019904
• endosome
  http://purl.obolibrary.org/obo/GO_0005768

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map04662
• http://www.genome.jp/dbget-bin/www_bget?map04062
• http://www.genome.jp/dbget-bin/www_bget?map05220
• http://www.genome.jp/dbget-bin/www_bget?map04540
• http://www.genome.jp/dbget-bin/www_bget?map04660
• http://www.genome.jp/dbget-bin/www_bget?map04912
• http://www.genome.jp/dbget-bin/www_bget?map05213
• http://www.genome.jp/dbget-bin/www_bget?map05223
• http://www.genome.jp/dbget-bin/www_bget?map05215
• http://www.genome.jp/dbget-bin/www_bget?map04650
• http://www.genome.jp/dbget-bin/www_bget?map05200
• http://www.genome.jp/dbget-bin/www_bget?map05221
• http://www.genome.jp/dbget-bin/www_bget?map04664
• http://www.genome.jp/dbget-bin/www_bget?map04012
• http://www.genome.jp/dbget-bin/www_bget?map04320
• http://www.genome.jp/dbget-bin/www_bget?map04910
• http://www.genome.jp/dbget-bin/www_bget?map05211
• http://www.genome.jp/dbget-bin/www_bget?map04380
• http://www.genome.jp/dbget-bin/www_bget?map04630
• http://www.genome.jp/dbget-bin/www_bget?map05160
• http://www.genome.jp/dbget-bin/www_bget?map04010
• http://www.genome.jp/dbget-bin/www_bget?map04510
• http://www.genome.jp/dbget-bin/www_bget?map04722
• http://www.genome.jp/dbget-bin/www_bget?map05214

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Dorso-ventral axis formation
• B cell receptor signaling pathway
• Osteoclast differentiation
• Prostate cancer
• GnRH signaling pathway
• Glioma
• Natural killer cell mediated cytotoxicity
• Hepatitis C
• Renal cell carcinoma
• Gap junction
• Endometrial cancer
• ErbB signaling pathway
• Fc epsilon RI signaling pathway
• Jak-STAT signaling pathway
• Chemokine signaling pathway
• MAPK signaling pathway
• Pathways in cancer
• Neurotrophin signaling pathway
• Acute myeloid leukemia
• T cell receptor signaling pathway
• Focal adhesion
• Insulin signaling pathway
• Chronic myeloid leukemia
• Non-small cell lung cancer