CD12346

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD12346

CD12346

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Hck

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• hemopoietic cell kinase

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• B cell/myeloid kinase
• p56-HCK/p59-HCK
• hemopoietic cell kinase
• tyrosine-protein kinase HCK
• B-cell/myeloid kinase

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• Bmk
• Hck-1
• AI849071

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/15162

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• hemopoietic cell kinase
  http://metadb.riken.jp/db/mgi_rdf/MGI:96052

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_001172117
• https://www.ncbi.nlm.nih.gov/nuccore/NM_010407

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000003283

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.715

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=142370

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• C A. Lowell, et.al., Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions., The Journal of cell biology, 1996, 133
  http://rdf.ncbi.nlm.nih.gov/pubmed/8666673
• N A. Jenkins, et.al., Assignment of secretogranin I locus to mouse chromosome 2 by in situ hybridization and interspecific backcross analysis., Genomics, 1991, 11
  http://rdf.ncbi.nlm.nih.gov/pubmed/1685143
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• D A. Holtzman, et.al., Isolation and sequence of a cDNA corresponding to a src-related gene expressed in murine hemopoietic cells., Proceedings of the National Academy of Sciences of the United States of America, 1987, 84
  http://rdf.ncbi.nlm.nih.gov/pubmed/3317404
• P. Lock, et.al., Functional analysis and nucleotide sequence of the promoter region of the murine hck gene., Molecular and cellular biology, 1990, 10
  http://rdf.ncbi.nlm.nih.gov/pubmed/2388619
• M J. Klemsz, et.al., Nucleotide sequence of the mouse hck gene., Nucleic acids research, 1987, 15
  http://rdf.ncbi.nlm.nih.gov/pubmed/3684607
• P. Lock, et.al., Two isoforms of murine hck, generated by utilization of alternative translational initiation codons, exhibit different patterns of subcellular localization., Molecular and cellular biology, 1991, 11
  http://rdf.ncbi.nlm.nih.gov/pubmed/1875927
• C A. Lowell, et.al., Deficiency of the Hck and Src tyrosine kinases results in extreme levels of extramedullary hematopoiesis., Blood, 1996, 87
  http://rdf.ncbi.nlm.nih.gov/pubmed/8634424
• K B. Avraham, et.al., Murine chromosomal location of four hepatocyte-enriched transcription factors: HNF-3 alpha, HNF-3 beta, HNF-3 gamma, and HNF-4., Genomics, 1992, 13
  http://rdf.ncbi.nlm.nih.gov/pubmed/1612587
• Michael P. Nelson, et.al., IL-33 and M2a alveolar macrophages promote lung defense against the atypical fungal pathogen Pneumocystis murina., Journal of immunology (Baltimore, Md. : 1950), 2011, 186
  http://rdf.ncbi.nlm.nih.gov/pubmed/21220696

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• regulation of sequence-specific DNA binding transcription factor activity
  http://purl.obolibrary.org/obo/GO_0051090
• membrane
  http://purl.obolibrary.org/obo/GO_0016020
• protein autophosphorylation
  http://purl.obolibrary.org/obo/GO_0046777
• regulation of cell shape
  http://purl.obolibrary.org/obo/GO_0008360
• protein phosphorylation
  http://purl.obolibrary.org/obo/GO_0006468
• regulation of phagocytosis
  http://purl.obolibrary.org/obo/GO_0050764
• focal adhesion
  http://purl.obolibrary.org/obo/GO_0005925
• extrinsic component of cytoplasmic side of plasma membrane
  http://purl.obolibrary.org/obo/GO_0031234
• negative regulation of apoptotic process
  http://purl.obolibrary.org/obo/GO_0043066
• peptidyl-tyrosine phosphorylation
  http://purl.obolibrary.org/obo/GO_0018108
• caveola
  http://purl.obolibrary.org/obo/GO_0005901
• positive regulation of cell proliferation
  http://purl.obolibrary.org/obo/GO_0008284
• transferase activity
  http://purl.obolibrary.org/obo/GO_0016740
• kinase activity
  http://purl.obolibrary.org/obo/GO_0016301
• lysosome
  http://purl.obolibrary.org/obo/GO_0005764
• nucleotide binding
  http://purl.obolibrary.org/obo/GO_0000166
• transferase activity, transferring phosphorus-containing groups
  http://purl.obolibrary.org/obo/GO_0016772
• phagocytosis
  http://purl.obolibrary.org/obo/GO_0006909
• regulation of podosome assembly
  http://purl.obolibrary.org/obo/GO_0071801
• phosphorylation
  http://purl.obolibrary.org/obo/GO_0016310
• protein tyrosine kinase activity
  http://purl.obolibrary.org/obo/GO_0004713
• positive regulation of actin cytoskeleton reorganization
  http://purl.obolibrary.org/obo/GO_2000251
• defense response to Gram-positive bacterium
  http://purl.obolibrary.org/obo/GO_0050830
• non-membrane spanning protein tyrosine kinase activity
  http://purl.obolibrary.org/obo/GO_0004715
• ATP binding
  http://purl.obolibrary.org/obo/GO_0005524
• protein kinase activity
  http://purl.obolibrary.org/obo/GO_0004672

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map04062
• http://www.genome.jp/dbget-bin/www_bget?map04666

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Chemokine signaling pathway
• Fc gamma R-mediated phagocytosis