CD12403

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD12403

CD12403

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Chek1

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• checkpoint kinase 1 homolog (S. pombe)

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• CHK1 checkpoint homolog
• serine/threonine-protein kinase Chk1
• checkpoint kinase-1
• checkpoint kinase 1 homolog (S. pombe)
• rad27 homolog

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• Chk1
• rad27
• C85740

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/12649

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• checkpoint kinase 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:1202065

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_007691

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000032113

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.16753

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=603078

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• H. Takai, et.al., Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice., Genes & development, 2000, 14
  http://rdf.ncbi.nlm.nih.gov/pubmed/10859163
• Hiroyuki. Niida, et.al., Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo., The EMBO journal, 2010, 29
  http://rdf.ncbi.nlm.nih.gov/pubmed/20834228
• Y. Sanchez, et.al., Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25., Science (New York, N.Y.), 1997, 277
  http://rdf.ncbi.nlm.nih.gov/pubmed/9278511
• G. Flaggs, et.al., Atm-dependent interactions of a mammalian chk1 homolog with meiotic chromosomes., Current biology : CB, 1997, 7
  http://rdf.ncbi.nlm.nih.gov/pubmed/9382850
• T. Fishler, et.al., Genetic instability and mammary tumor formation in mice carrying mammary-specific disruption of Chk1 and p53., Oncogene, 2010, 29
  http://rdf.ncbi.nlm.nih.gov/pubmed/20473325
• P. Chen, et.al., The 1.7 A crystal structure of human cell cycle checkpoint kinase Chk1: implications for Chk1 regulation., Cell, 2000, 100
  http://rdf.ncbi.nlm.nih.gov/pubmed/10761933
• Q. Liu, et.al., Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint., Genes & development, 2000, 14
  http://rdf.ncbi.nlm.nih.gov/pubmed/10859164
• Elke. Malzer, et.al., Impaired tissue growth is mediated by checkpoint kinase 1 (CHK1) in the integrated stress response., Journal of cell science, 2010, 123
  http://rdf.ncbi.nlm.nih.gov/pubmed/20682638
• James R A. Hutchins, et.al., Systematic analysis of human protein complexes identifies chromosome segregation proteins., Science (New York, N.Y.), 2010, 328
  http://rdf.ncbi.nlm.nih.gov/pubmed/20360068

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• G2 DNA damage checkpoint
  http://purl.obolibrary.org/obo/GO_0031572
• nucleotide binding
  http://purl.obolibrary.org/obo/GO_0000166
• regulation of histone H3-K9 acetylation
  http://purl.obolibrary.org/obo/GO_2000615
• chromatin
  http://purl.obolibrary.org/obo/GO_0000785
• regulation of mitotic centrosome separation
  http://purl.obolibrary.org/obo/GO_0046602
• DNA damage induced protein phosphorylation
  http://purl.obolibrary.org/obo/GO_0006975
• protein serine/threonine kinase activity
  http://purl.obolibrary.org/obo/GO_0004674
• peptidyl-threonine phosphorylation
  http://purl.obolibrary.org/obo/GO_0018107
• condensed nuclear chromosome
  http://purl.obolibrary.org/obo/GO_0000794
• centrosome
  http://purl.obolibrary.org/obo/GO_0005813
• regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
  http://purl.obolibrary.org/obo/GO_0010767
• cytoplasm
  http://purl.obolibrary.org/obo/GO_0005737
• cellular response to DNA damage stimulus
  http://purl.obolibrary.org/obo/GO_0006974
• cell cycle
  http://purl.obolibrary.org/obo/GO_0007049
• nucleus
  http://purl.obolibrary.org/obo/GO_0005634
• transferase activity
  http://purl.obolibrary.org/obo/GO_0016740
• chromatin-mediated maintenance of transcription
  http://purl.obolibrary.org/obo/GO_0048096
• G2/M transition of mitotic cell cycle
  http://purl.obolibrary.org/obo/GO_0000086
• protein kinase activity
  http://purl.obolibrary.org/obo/GO_0004672
• ATP binding
  http://purl.obolibrary.org/obo/GO_0005524
• regulation of double-strand break repair via homologous recombination
  http://purl.obolibrary.org/obo/GO_0010569
• transferase activity, transferring phosphorus-containing groups
  http://purl.obolibrary.org/obo/GO_0016772
• regulation of S phase
  http://purl.obolibrary.org/obo/GO_0033261
• replication fork
  http://purl.obolibrary.org/obo/GO_0005657
• kinase activity
  http://purl.obolibrary.org/obo/GO_0016301
• cytoskeleton
  http://purl.obolibrary.org/obo/GO_0005856
• DNA repair
  http://purl.obolibrary.org/obo/GO_0006281
• phosphorylation
  http://purl.obolibrary.org/obo/GO_0016310
• protein phosphorylation
  http://purl.obolibrary.org/obo/GO_0006468
• protein binding
  http://purl.obolibrary.org/obo/GO_0005515
• histone kinase activity (H3-T11 specific)
  http://purl.obolibrary.org/obo/GO_0035402
• negative regulation of mitotic nuclear division
  http://purl.obolibrary.org/obo/GO_0045839
• DNA damage checkpoint
  http://purl.obolibrary.org/obo/GO_0000077
• histone H3-T11 phosphorylation
  http://purl.obolibrary.org/obo/GO_0035407

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map04110
• http://www.genome.jp/dbget-bin/www_bget?map05166
• http://www.genome.jp/dbget-bin/www_bget?map04115

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Cell cycle
• p53 signaling pathway
• HTLV-I infection