CD12519

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD12519

CD12519

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Ern1

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• endoplasmic reticulum (ER) to nucleus signalling 1

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• endoplasmic reticulum (ER) to nucleus signalling 1
• endoplasmic reticulum-to-nucleus signaling 1
• inositol-requiring 1 alpha
• inositol-requiring protein 1
• ire1-alpha
• serine/threonine-protein kinase/endoribonuclease IRE1

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• 9030414B18Rik
• AI225830
• C85377
• Ire1a
• Ire1alpha
• Ire1p

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/78943

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• endoplasmic reticulum (ER) to nucleus signalling 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:1930134

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_023913

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000020715

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.340943

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=604033

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• K. Araki, et.al., Exchangeable gene trap using the Cre/mutated lox system., Cellular and molecular biology (Noisy-le-Grand, France), 1999, 45
  http://rdf.ncbi.nlm.nih.gov/pubmed/10512203
• F. Urano, et.al., Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1., Science (New York, N.Y.), 2000, 287
  http://rdf.ncbi.nlm.nih.gov/pubmed/10650002
• H P. Harding, et.al., Perk is essential for translational regulation and cell survival during the unfolded protein response., Molecular cell, 2000, 5
  http://rdf.ncbi.nlm.nih.gov/pubmed/10882126
• K. Miyoshi, et.al., Characterization of mouse Ire1 alpha: cloning, mRNA localization in the brain and functional analysis in a neural cell line., Brain research. Molecular brain research, 2000, 85
  http://rdf.ncbi.nlm.nih.gov/pubmed/11146108
• Gregor. Auf, et.al., Inositol-requiring enzyme 1alpha is a key regulator of angiogenesis and invasion in malignant glioma., Proceedings of the National Academy of Sciences of the United States of America, 2010, 107
  http://rdf.ncbi.nlm.nih.gov/pubmed/20702765
• Han. Li, et.al., Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering., Proceedings of the National Academy of Sciences of the United States of America, 2010, 107
  http://rdf.ncbi.nlm.nih.gov/pubmed/20798350
他4件を見る
• Takao. Iwawaki, et.al., IRE1α disruption causes histological abnormality of exocrine tissues, increase of blood glucose level, and decrease of serum immunoglobulin level., PloS one, 2010, 5
  http://rdf.ncbi.nlm.nih.gov/pubmed/20885949
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• Jun. Wu, et.al., The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α/ATF6α complex., Cell metabolism, 2011, 13
  http://rdf.ncbi.nlm.nih.gov/pubmed/21284983
• X Z. Wang, et.al., Cloning of mammalian Ire1 reveals diversity in the ER stress responses., The EMBO journal, 1998, 17
  http://rdf.ncbi.nlm.nih.gov/pubmed/9755171

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• nucleotide binding
  http://purl.obolibrary.org/obo/GO_0000166
• magnesium ion binding
  http://purl.obolibrary.org/obo/GO_0000287
• catalytic activity
  http://purl.obolibrary.org/obo/GO_0003824
• endonuclease activity
  http://purl.obolibrary.org/obo/GO_0004519
• endoribonuclease activity
  http://purl.obolibrary.org/obo/GO_0004521
• protein kinase activity
  http://purl.obolibrary.org/obo/GO_0004672
他26件を見る
• protein serine/threonine kinase activity
  http://purl.obolibrary.org/obo/GO_0004674
• ATP binding
  http://purl.obolibrary.org/obo/GO_0005524
• nuclear inner membrane
  http://purl.obolibrary.org/obo/GO_0005637
• endoplasmic reticulum
  http://purl.obolibrary.org/obo/GO_0005783
• endoplasmic reticulum membrane
  http://purl.obolibrary.org/obo/GO_0005789
• transcription, DNA-templated
  http://purl.obolibrary.org/obo/GO_0006351
• regulation of transcription, DNA-templated
  http://purl.obolibrary.org/obo/GO_0006355
• mRNA processing
  http://purl.obolibrary.org/obo/GO_0006397
• protein phosphorylation
  http://purl.obolibrary.org/obo/GO_0006468
• apoptotic process
  http://purl.obolibrary.org/obo/GO_0006915
• response to stress
  http://purl.obolibrary.org/obo/GO_0006950
• response to unfolded protein
  http://purl.obolibrary.org/obo/GO_0006986
• activation of signaling protein activity involved in unfolded protein response
  http://purl.obolibrary.org/obo/GO_0006987
• cell cycle arrest
  http://purl.obolibrary.org/obo/GO_0007050
• metabolic process
  http://purl.obolibrary.org/obo/GO_0008152
• membrane
  http://purl.obolibrary.org/obo/GO_0016020
• integral component of membrane
  http://purl.obolibrary.org/obo/GO_0016021
• kinase activity
  http://purl.obolibrary.org/obo/GO_0016301
• phosphorylation
  http://purl.obolibrary.org/obo/GO_0016310
• transferase activity
  http://purl.obolibrary.org/obo/GO_0016740
• transferase activity, transferring phosphorus-containing groups
  http://purl.obolibrary.org/obo/GO_0016772
• hydrolase activity
  http://purl.obolibrary.org/obo/GO_0016787
• integral component of endoplasmic reticulum membrane
  http://purl.obolibrary.org/obo/GO_0030176
• endoplasmic reticulum unfolded protein response
  http://purl.obolibrary.org/obo/GO_0030968
• protein autophosphorylation
  http://purl.obolibrary.org/obo/GO_0046777
• metal ion binding
  http://purl.obolibrary.org/obo/GO_0046872

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map04141
• http://www.genome.jp/dbget-bin/www_bget?map05010

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Alzheimer's disease
• Protein processing in endoplasmic reticulum