CD12931

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD12931

CD12931

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Ctsl

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• cathepsin L

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• nackt
• furless
• cathepsin L1
• p39 cysteine proteinase
• cathepsin L

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• MEP
• Ctsl1
• major excreted protein
• 1190035F06Rik
• Cat L
• fs
• nkt

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/13039

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• cathepsin L
  http://metadb.riken.jp/db/mgi_rdf/MGI:88564

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_009984

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000021477

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.930

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=603308
• https://www.omim.org/entry/603434?search=603434&highlight=116880

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• R T. Hamilton, et.al., Developmental expression of cathepsin L and c-rasHa in the mouse placenta., Molecular reproduction and development, 1991, 30
  http://rdf.ncbi.nlm.nih.gov/pubmed/1751032
• Peter. Duewell, et.al., NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals., Nature, 2010, 464
  http://rdf.ncbi.nlm.nih.gov/pubmed/20428172
• Patrick L J M. Zeeuwen, et.al., The cystatin M/E-cathepsin L balance is essential for tissue homeostasis in epidermis, hair follicles, and cornea., FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2010, 24
  http://rdf.ncbi.nlm.nih.gov/pubmed/20495178
• Julia. Dennemärker, et.al., Impaired turnover of autophagolysosomes in cathepsin L deficiency., Biological chemistry, 2010, 391
  http://rdf.ncbi.nlm.nih.gov/pubmed/20536383
• N A. Stearns, et.al., Comparison of cathepsin L synthesized by normal and transformed cells at the gene, message, protein, and oligosaccharide levels., Archives of biochemistry and biophysics, 1990, 283
  http://rdf.ncbi.nlm.nih.gov/pubmed/2275556
• B R. Troen, et.al., Cloning and expression of the gene for the major excreted protein of transformed mouse fibroblasts. A secreted lysosomal protease regulated by transformation., The Journal of biological chemistry, 1988, 263
  http://rdf.ncbi.nlm.nih.gov/pubmed/2826441
• L J. Joseph, et.al., Complete nucleotide and deduced amino acid sequences of human and murine preprocathepsin L. An abundant transcript induced by transformation of fibroblasts., The Journal of clinical investigation, 1988, 81
  http://rdf.ncbi.nlm.nih.gov/pubmed/2835398
• Akiko. Yamada, et.al., Cathepsin L inhibition prevents murine autoimmune diabetes via suppression of CD8(+) T cell activity., PloS one, 2010, 5
  http://rdf.ncbi.nlm.nih.gov/pubmed/20877570
• Spela. Konjar, et.al., Human and mouse perforin are processed in part through cleavage by the lysosomal cysteine proteinase cathepsin L., Immunology, 2010, 131
  http://rdf.ncbi.nlm.nih.gov/pubmed/20497254
• T. Spies, et.al., Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter., Nature, 1991, 351
  http://rdf.ncbi.nlm.nih.gov/pubmed/2034277

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• external side of plasma membrane
  http://purl.obolibrary.org/obo/GO_0009897
• stem cell differentiation
  http://purl.obolibrary.org/obo/GO_0048863
• secretory granule
  http://purl.obolibrary.org/obo/GO_0030141
• kininogen binding
  http://purl.obolibrary.org/obo/GO_0030984
• perikaryon
  http://purl.obolibrary.org/obo/GO_0043204
• macromolecular complex binding
  http://purl.obolibrary.org/obo/GO_0044877
• soluble fraction
  http://purl.obolibrary.org/obo/GO_0005625
• microvillus
  http://purl.obolibrary.org/obo/GO_0005902
• hydrolase activity
  http://purl.obolibrary.org/obo/GO_0016787
• histone binding
  http://purl.obolibrary.org/obo/GO_0042393
• aminopeptidase activity
  http://purl.obolibrary.org/obo/GO_0004177
• epithelial tube branching involved in lung morphogenesis
  http://purl.obolibrary.org/obo/GO_0060441
• cysteine-type endopeptidase activity
  http://purl.obolibrary.org/obo/GO_0004197
• apical part of cell
  http://purl.obolibrary.org/obo/GO_0045177
• protein binding
  http://purl.obolibrary.org/obo/GO_0005515
• neuron projection
  http://purl.obolibrary.org/obo/GO_0043005
• metabolic process
  http://purl.obolibrary.org/obo/GO_0008152
• cysteine-type peptidase activity
  http://purl.obolibrary.org/obo/GO_0008234
• cell communication
  http://purl.obolibrary.org/obo/GO_0007154
• cytoplasm
  http://purl.obolibrary.org/obo/GO_0005737
• peptidase activity
  http://purl.obolibrary.org/obo/GO_0008233
• vacuole
  http://purl.obolibrary.org/obo/GO_0005773
• nucleolus
  http://purl.obolibrary.org/obo/GO_0005730
• lysosome
  http://purl.obolibrary.org/obo/GO_0005764
• peptide binding
  http://purl.obolibrary.org/obo/GO_0042277
• proteolysis
  http://purl.obolibrary.org/obo/GO_0006508

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map04612
• http://www.genome.jp/dbget-bin/www_bget?map05323
• http://www.genome.jp/dbget-bin/www_bget?map04145
• http://www.genome.jp/dbget-bin/www_bget?map04142

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Lysosome
• Rheumatoid arthritis
• Phagosome
• Antigen processing and presentation