CD13014

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD13014

CD13014

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Aph1a

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• anterior pharynx defective 1a homolog (C. elegans)

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• APH-1a
• gamma-secretase subunit APH-1A
• anterior pharynx defective 1a homolog (C. elegans)
• aph-1alpha

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• 6530402N02Rik

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/226548

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• aph1 homolog A, gamma secretase subunit
  http://metadb.riken.jp/db/mgi_rdf/MGI:2385110

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_146134
• https://www.ncbi.nlm.nih.gov/nuccore/NM_146104

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000015750

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.306954

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=607629

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• Kulandaivelu S. Vetrivel, et.al., Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes., The Journal of biological chemistry, 2004, 279
  http://rdf.ncbi.nlm.nih.gov/pubmed/15322084
• Jianxin. Tan, et.al., Residues at P2-P1 positions of epsilon- and zeta-cleavage sites are important in formation of beta-amyloid peptide., Neurobiology of disease, 2009, 36
  http://rdf.ncbi.nlm.nih.gov/pubmed/19716417
• Sébastien S. Hébert, et.al., Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity., Neurobiology of disease, 2004, 17
  http://rdf.ncbi.nlm.nih.gov/pubmed/15474363
• Nobuo. Sanjo, et.al., Localization and trafficking of endogenous anterior pharynx-defective 1, a component of Alzheimer's disease related gamma-secretase., Neuroscience letters, 2010, 483
  http://rdf.ncbi.nlm.nih.gov/pubmed/20674680
• Guojun. Ma, et.al., APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, 25
  http://rdf.ncbi.nlm.nih.gov/pubmed/15634781
• Tong. Li, et.al., Moderate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based liabilities., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007, 27
  http://rdf.ncbi.nlm.nih.gov/pubmed/17913918
• Allen C. Chen, et.al., Aph-1 associates directly with full-length and C-terminal fragments of gamma-secretase substrates., The Journal of biological chemistry, 2010, 285
  http://rdf.ncbi.nlm.nih.gov/pubmed/20145246
• Hui-Teng. Cheng, et.al., Gamma-secretase activity is dispensable for mesenchyme-to-epithelium transition but required for podocyte and proximal tubule formation in developing mouse kidney., Development (Cambridge, England), 2003, 130
  http://rdf.ncbi.nlm.nih.gov/pubmed/12952904
• Sheu-Fen. Lee, et.al., Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch., The Journal of biological chemistry, 2002, 277
  http://rdf.ncbi.nlm.nih.gov/pubmed/12297508
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• peptidase activity
  http://purl.obolibrary.org/obo/GO_0008233
• endopeptidase activity
  http://purl.obolibrary.org/obo/GO_0004175
• metanephros development
  http://purl.obolibrary.org/obo/GO_0001656
• membrane protein intracellular domain proteolysis
  http://purl.obolibrary.org/obo/GO_0031293
• Golgi apparatus
  http://purl.obolibrary.org/obo/GO_0005794
• integral component of membrane
  http://purl.obolibrary.org/obo/GO_0016021
• membrane
  http://purl.obolibrary.org/obo/GO_0016020
• endoplasmic reticulum
  http://purl.obolibrary.org/obo/GO_0005783
• integral component of plasma membrane
  http://purl.obolibrary.org/obo/GO_0005887
• amyloid precursor protein catabolic process
  http://purl.obolibrary.org/obo/GO_0042987
• Notch signaling pathway
  http://purl.obolibrary.org/obo/GO_0007219
• positive regulation of catalytic activity
  http://purl.obolibrary.org/obo/GO_0043085
• protein binding
  http://purl.obolibrary.org/obo/GO_0005515
• membrane protein ectodomain proteolysis
  http://purl.obolibrary.org/obo/GO_0006509
• Notch receptor processing
  http://purl.obolibrary.org/obo/GO_0007220
• protein processing
  http://purl.obolibrary.org/obo/GO_0016485

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map05010
• http://www.genome.jp/dbget-bin/www_bget?map04330

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Alzheimer's disease
• Notch signaling pathway