CD15660

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD15660

CD15660

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Adam8

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• a disintegrin and metallopeptidase domain 8

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• a disintegrin and metalloprotease domain 8
• a disintegrin and metalloprotease domain (ADAM) 8
• macrophage cysteine-rich glycoprotein
• cell surface antigen MS2
• a disintegrin and metallopeptidase domain 8
• ADAM 8
• disintegrin and metalloproteinase domain-containing protein 8

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• CD156a
• CD156
• MS2
• E430039A18Rik

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/11501

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• a disintegrin and metallopeptidase domain 8
  http://metadb.riken.jp/db/mgi_rdf/MGI:107825

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_007403

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000025473

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.15969

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=602267

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• S. Yoshida, et.al., Molecular cloning of cDNA encoding MS2 antigen, a novel cell surface antigen strongly expressed in murine monocytic lineage., International immunology, 1990, 2
  http://rdf.ncbi.nlm.nih.gov/pubmed/1982220
• M. Kataoka, et.al., Structure of the murine CD156 gene, characterization of its promoter, and chromosomal location., The Journal of biological chemistry, 1997, 272
  http://rdf.ncbi.nlm.nih.gov/pubmed/9218457
• Jörg W. Bartsch, et.al., Tumor necrosis factor-alpha (TNF-alpha) regulates shedding of TNF-alpha receptor 1 by the metalloprotease-disintegrin ADAM8: evidence for a protease-regulated feedback loop in neuroprotection., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, 30
  http://rdf.ncbi.nlm.nih.gov/pubmed/20826683
• Atsuo. Iida, et.al., [ADAM8-dependent onset of blood circulation in zebrafish]., Seikagaku. The Journal of Japanese Biochemical Society, 2010, 82
  http://rdf.ncbi.nlm.nih.gov/pubmed/21077325
• R T. Ballock, et.al., Inhibition of the chondrocyte phenotype by retinoic acid involves upregulation of metalloprotease genes independent of TGF-beta., Journal of cellular physiology, 1994, 159
  http://rdf.ncbi.nlm.nih.gov/pubmed/8163572
• Klaus. Gossens, et.al., Deficiency of the metalloproteinase-disintegrin ADAM8 is associated with thymic hyper-cellularity., PloS one, 2010, 5
  http://rdf.ncbi.nlm.nih.gov/pubmed/20856819
• K. Yoshiyama, et.al., CD156 (human ADAM8): expression, primary amino acid sequence, and gene location., Genomics, 1997, 41
  http://rdf.ncbi.nlm.nih.gov/pubmed/9126482
• Atsuo. Iida, et.al., Metalloprotease-dependent onset of blood circulation in zebrafish., Current biology : CB, 2010, 20
  http://rdf.ncbi.nlm.nih.gov/pubmed/20605457
• M. Ito, et.al., Preservation of an inbred mouse strain by the storage of frozen embryos: an estimate of the time of occurrence of a serum IgG1 deficiency mutation found in MRL-lpr., Laboratory animal science, 1992, 42
  http://rdf.ncbi.nlm.nih.gov/pubmed/1318459
• Ryan L. Ashley, et.al., Deletion of the Isg15 gene results in up-regulation of decidual cell survival genes and down-regulation of adhesion genes: implication for regulation by IL-1beta., Endocrinology, 2010, 151
  http://rdf.ncbi.nlm.nih.gov/pubmed/20660068

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• calcium ion binding
  http://purl.obolibrary.org/obo/GO_0005509
• cytoplasm
  http://purl.obolibrary.org/obo/GO_0005737
• hydrolase activity
  http://purl.obolibrary.org/obo/GO_0016787
• integrin binding
  http://purl.obolibrary.org/obo/GO_0005178
• positive regulation of membrane protein ectodomain proteolysis
  http://purl.obolibrary.org/obo/GO_0051044
• regulation of cell-cell adhesion
  http://purl.obolibrary.org/obo/GO_0022407
• phagolysosome
  http://purl.obolibrary.org/obo/GO_0032010
• cell adhesion molecule binding
  http://purl.obolibrary.org/obo/GO_0050839
• positive regulation of inflammatory response
  http://purl.obolibrary.org/obo/GO_0050729
• zinc ion binding
  http://purl.obolibrary.org/obo/GO_0008270
• podosome
  http://purl.obolibrary.org/obo/GO_0002102
• specific granule
  http://purl.obolibrary.org/obo/GO_0042581
• tissue morphogenesis
  http://purl.obolibrary.org/obo/GO_0048729
• positive regulation of NF-kappaB transcription factor activity
  http://purl.obolibrary.org/obo/GO_0051092
• membrane fusion
  http://purl.obolibrary.org/obo/GO_0061025
• plasma membrane
  http://purl.obolibrary.org/obo/GO_0005886
• peptidase activity
  http://purl.obolibrary.org/obo/GO_0008233
• positive regulation of cell adhesion
  http://purl.obolibrary.org/obo/GO_0045785
• positive regulation of T cell differentiation in thymus
  http://purl.obolibrary.org/obo/GO_0033089
• activation of MAPK activity involved in innate immune response
  http://purl.obolibrary.org/obo/GO_0035419
• positive regulation of bone resorption
  http://purl.obolibrary.org/obo/GO_0045780
• angiogenesis
  http://purl.obolibrary.org/obo/GO_0001525
• regulation of osteoclast differentiation
  http://purl.obolibrary.org/obo/GO_0045670
• inflammatory response
  http://purl.obolibrary.org/obo/GO_0006954
• protein binding
  http://purl.obolibrary.org/obo/GO_0005515
• cell-cell adhesion
  http://purl.obolibrary.org/obo/GO_0098609
• proteolysis
  http://purl.obolibrary.org/obo/GO_0006508
• metal ion binding
  http://purl.obolibrary.org/obo/GO_0046872
• integral component of membrane
  http://purl.obolibrary.org/obo/GO_0016021
• cell morphogenesis
  http://purl.obolibrary.org/obo/GO_0000902
• blood vessel endothelial cell migration
  http://purl.obolibrary.org/obo/GO_0043534
• leukocyte migration involved in inflammatory response
  http://purl.obolibrary.org/obo/GO_0002523
• positive regulation of thymocyte apoptotic process
  http://purl.obolibrary.org/obo/GO_0070245
• lymphocyte chemotaxis
  http://purl.obolibrary.org/obo/GO_0048247
• positive regulation of protein kinase B signaling
  http://purl.obolibrary.org/obo/GO_0051897
• thymocyte aggregation
  http://purl.obolibrary.org/obo/GO_0071594
• integral component of plasma membrane
  http://purl.obolibrary.org/obo/GO_0005887
• cellular response to hypoxia
  http://purl.obolibrary.org/obo/GO_0071456
• alpha9-beta1 integrin-ADAM8 complex
  http://purl.obolibrary.org/obo/GO_0071133
• metalloendopeptidase activity
  http://purl.obolibrary.org/obo/GO_0004222
• negative regulation of neuron apoptotic process
  http://purl.obolibrary.org/obo/GO_0043524
• tertiary granule
  http://purl.obolibrary.org/obo/GO_0070820
• metallopeptidase activity
  http://purl.obolibrary.org/obo/GO_0008237
• cell surface
  http://purl.obolibrary.org/obo/GO_0009986
• dense core granule membrane
  http://purl.obolibrary.org/obo/GO_0032127
• positive regulation of acute inflammatory response
  http://purl.obolibrary.org/obo/GO_0002675
• positive regulation of cell migration
  http://purl.obolibrary.org/obo/GO_0030335
• positive regulation of leukocyte migration
  http://purl.obolibrary.org/obo/GO_0002687
• positive regulation of tumor necrosis factor (ligand) superfamily member 11 production
  http://purl.obolibrary.org/obo/GO_2000309
• membrane
  http://purl.obolibrary.org/obo/GO_0016020
• cell-matrix adhesion
  http://purl.obolibrary.org/obo/GO_0007160
• positive regulation of cellular extravasation
  http://purl.obolibrary.org/obo/GO_0002693
• integrin-mediated signaling pathway
  http://purl.obolibrary.org/obo/GO_0007229

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName